- 专利标题： Encapsulated agents and methods of making and using thereof
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申请号： US14709090申请日： 2015-05-11
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公开(公告)号： US10022451B2公开(公告)日： 2018-07-17
- 发明人: Jin Xie , Zipeng Zhen , Wei Tang
- 申请人： University of Georgia Research Foundation, Inc.
- 申请人地址： US GA Athens
- 专利权人： University of Georgia Research Foundation, Inc.
- 当前专利权人： University of Georgia Research Foundation, Inc.
- 当前专利权人地址： US GA Athens
- 代理机构： Meunier Carlin & Curfman LLC
- 主分类号： A61N5/06
- IPC分类号： A61N5/06 ; A61K47/48 ; A61K31/704 ; A61K9/127 ; A61K41/00 ; A61K33/06 ; A61K33/22 ; A61K33/26 ; A61K33/30
摘要：
The subject matter disclosed herein relates to compositions that contain a protein cage and a therapeutic agent, such as a photosensitizer. The protein cage is a protein that binds metal ion. The composition can further contain a cell recognition moiety. The methods disclosed are for permeabilizing the endothelial lining of a cancerous tissue or for treating a cancerous tissue to cause therapeutic injury resulting in the reduction of at least one of the surface area, the depth, and the amount of the tissue affected by the cancerous condition, in a subject.
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