公开(公告)号：US5273633A

公开(公告)日：1993-12-28

申请号：US911607

申请日：1992-07-10

申请人： Tiansong Wang

发明人： Tiansong Wang

IPC分类号： G01N21/03 ,  G01N21/05 ,  G01N27/447 ,  G01N30/74 ,  G01N27/26

CPC分类号： G01N21/05 ,  G01N27/44721 ,  G01N2021/0346 ,  G01N2021/052

摘要： The present invention features a system for detecting a substance in a fluid sample. A capillary is provided with a longitudinal axis and a channel is formed in it for receiving a fluid sample. The channel is disposed parallel to the longitudinal axis. A reflecting surface surrounds the outer surface of the capillary for reflecting electromagnetic energy. The reflecting surface has an incident window for allowing the electromagnetic energy to enter the capillary and an exit window for allowing the electromagnetic energy to exit the capillary. The exit window is disposed downstream of the incident window with respect to the longitudinal axis, so that the electromagnetic energy that enters the capillary is internally reflected more than once by the reflecting surface.

摘要翻译： 本发明的特征在于用于检测流体样品中的物质的系统。 毛细管设置有纵向轴线，并且在其中形成有用于接收流体样品的通道。 通道平行于纵向轴线设置。 反射表面围绕毛细管的外表面以反射电磁能。 反射表面具有用于允许电磁能量进入毛细管的入射窗口和用于允许电磁能量离开毛细管的出射窗口。 出射窗口相对于纵向轴线布置在入射窗口的下游，使得进入毛细管的电磁能量被反射表面反射多于一次。

公开(公告)号：US20140003081A1

公开(公告)日：2014-01-02

申请号：US13534498

申请日：2012-06-27

申请人： Tiansong Wang

发明人： Tiansong Wang

IPC分类号： G02B6/00

CPC分类号： C07K1/26 ,  G01N27/44721 ,  G02B6/262

摘要： An optical fiber (500) illuminates the bore (520) of a capillary tube (515) that is used for separating chemicals by capillary electrophoresis (CE). The fiber terminates in either two sloped regions (525) and a curved region (530) or two sloped regions (705) and a flat region (700). Light from these regions is focused on the bore of the capillary tube. Since the fiber is sized to illuminate the core of a CE capillary, it is larger than fibers used in telecommunications and its sloped regions are at angles that would be unsuitable for use in telecommunications. The relatively large diameter of the capillary permits efficient use of a light source (905).

摘要翻译： 光纤（500）照射用于通过毛细管电泳（CE）分离化学品的毛细管（515）的孔（520）。 纤维终止于两个倾斜区域（525）和弯曲区域（530）或两个倾斜区域（705）和平坦区域（700）中。 来自这些区域的光聚焦于毛细管的孔。 由于光纤的尺寸可以照亮CE毛细管的核心，因此它大于电信中使用的光纤，其斜坡区域的角度将不适合用于电信。 毛细管的相对大的直径允许有效利用光源（905）。

公开(公告)号：US09034163B1

公开(公告)日：2015-05-19

申请号：US13682533

申请日：2012-11-20

申请人： Tiansong Wang

发明人： Tiansong Wang

IPC分类号： G01N27/403 ,  G01N27/447

CPC分类号： G01N27/44708 ,  G01N27/447 ,  G01N27/44756

摘要： An electrode assembly for capillary electrophoresis (CE) comprises a manifold (310), a connector (305) a sheath (300), and a seal (325). A capillary tube (100) passes through the manifold, the connector, the sheath, and the seal, stopping just beyond the end of the sheath. The sheath is fillable with water (330) or another fluid that cools the capillary tube in the vicinity of the electrode, thereby preventing degradation of a sample due to heat. The sheath may be metal or plastic with a metal sleeve electrode on its exterior. The sheath is sufficiently strong to penetrate a rubber or other pierceable cap on a vial. The manifold and connector incorporate an air path (605, 312, 307) so that when the electrode is fully inserted into a vial, the contents (650) of the vial are at atmospheric pressure (or another applied pressure or vacuum).

摘要翻译： 用于毛细管电泳（CE）的电极组件包括歧管（310），连接器（305），护套（300）和密封件（325）。 毛细管（100）穿过歧管，连接器，护套和密封件，刚好超出护套的端部。 护套可以用水（330）或在电极附近冷却毛细管的另一流体填充，从而防止样品由于热而劣化。 护套可以是金属或塑料，其外部具有金属套管电极。 护套足够坚固以穿透小瓶上的橡胶或其他可刺破的帽子。 歧管和连接器包括空气路径（605,312,307），使得当电极完全插入小瓶中时，小瓶的内容物（650）处于大气压（或另一个施加的压力或真空）。

公开(公告)号：US09090666B2

公开(公告)日：2015-07-28

申请号：US13534498

申请日：2012-06-27

申请人： Tiansong Wang

发明人： Tiansong Wang

IPC分类号： F21V7/04 ,  G02B6/00 ,  G02B6/036 ,  G09F13/00 ,  C07K1/26 ,  G01N27/447 ,  G02B6/26

CPC分类号： C07K1/26 ,  G01N27/44721 ,  G02B6/262

摘要： An optical fiber (500) illuminates the bore (520) of a capillary tube (515) that is used for separating chemicals by capillary electrophoresis (CE). The fiber terminates in either two sloped regions (525) and a curved region (530) or two sloped regions (705) and a flat region (700). Light from these regions is focused on the bore of the capillary tube. Since the fiber is sized to illuminate the core of a CE capillary, it is larger than fibers used in telecommunications and its sloped regions are at angles that would be unsuitable for use in telecommunications. The relatively large diameter of the capillary permits efficient use of a light source (905).

摘要翻译： 光纤（500）照射用于通过毛细管电泳（CE）分离化学品的毛细管（515）的孔（520）。 纤维终止于两个倾斜区域（525）和弯曲区域（530）或两个倾斜区域（705）和平坦区域（700）中。 来自这些区域的光聚焦于毛细管的孔。 由于光纤的尺寸可以照亮CE毛细管的核心，因此它大于电信中使用的光纤，其斜坡区域的角度将不适合用于电信。 毛细管的相对大的直径允许有效利用光源（905）。

公开(公告)号：US5124020A

公开(公告)日：1992-06-23

申请号：US412425

申请日：1989-09-26

申请人： Tiansong Wang

发明人： Tiansong Wang

IPC分类号： G01N27/447 ,  G01N30/74

CPC分类号： G01N30/74 ,  G01N27/44721

摘要： Adjustable aperture for photoelectric monitoring of a light transmitted through a capillary, wherein the aperture includes a device for providing a light beam having a predetermined limited extent in a vertical direction, a selectively operable device for limiting the extent of the light beam in a horizontal direction transverse to the vertical direction so that the extent in the horizontal direction can be selectively varied, and a device for positioning a capillary having longitudinal and diametral directions so that the diametral direction of the capillary lies in the vertical direction of the light beam and so that the beam of light passes through the capillary in a diametral dimensional thereof. The adjustable aperture can be used in combination with capillary zone electrophoresis and high performance liquid chromatography apparatus. Methods are provided for analyzing samples of one or more compounds by capillary zone electrophoresis or high performance liquid chromatography using the adjustable aperture.

摘要翻译： 用于对透过毛细管的光进行光电监测的可调孔径，其中所述孔包括用于提供在垂直方向上具有预定有限程度的光束的装置，用于限制光束在水平方向上的程度的选择性可操作的装置 横向于垂直方向，使得可以选择性地改变水平方向的程度;以及用于定位具有纵向和直径方向的毛细管的装置，使得毛细管的直径方向位于光束的垂直方向上，并且因此 光束在其直径上穿过毛细管。 可调孔径可与毛细管区带电泳和高效液相色谱仪组合使用。 提供了用于通过毛细管区带电泳分析一种或多种化合物的样品或使用可调孔径的高效液相色谱分析方法。