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公开(公告)号：US09090860B2
公开(公告)日：2015-07-28
申请号：US12575920
申请日：2009-10-08
申请人： Thomas G. Mason
发明人： Thomas G. Mason
CPC分类号： C11D11/00 , B81C2201/0149 , C25D5/48 , C25D15/02 , G03F7/09 , G03F7/11 , G03F7/16 , G03F7/40
摘要： A method for producing particles includes providing a relief template having a surface relief pattern adapted to impart structure to a plurality of particles while they are under production; depositing a radiation-sensitive material on the relief template; exposing portions of the radiation-sensitive material on the relief template using a beam of spatially patterned radiation; removing portions of the radiation-sensitive material after the exposing to reveal at least portions of surfaces of the plurality of particles; and separating at least a portion of the plurality of particles from the relief template. At least a portion of a structure of each of the plurality of particles is defined by a combination of the surface relief pattern and the spatially patterned radiation.
摘要翻译： 一种生产颗粒的方法包括提供一种具有表面浮雕图案的浮雕模板，其适于在生产时将结构赋予多个颗粒; 在辐射模板上沉积辐射敏感材料; 使用空间图案化的辐射束将曝光模板上的辐射敏感材料的部分曝光; 在曝光之后去除所述辐射敏感材料的部分以露出所述多个颗粒的表面的至少一部分; 以及从所述浮雕模板分离所述多个颗粒的至少一部分。 通过表面浮雕图案和空间图案化辐射的组合来限定多个颗粒中的每一个的结构的至少一部分。
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公开(公告)号：US08617798B2
公开(公告)日：2013-12-31
申请号：US12377773
申请日：2007-08-17
IPC分类号： G03F7/20
CPC分类号： G03F7/40 , B81C99/008 , B81C2201/038
摘要： A method of producing particles includes providing a substrate structure that comprises a solid substrate; forming a target structure on said substrate structure, said target structure comprising a radiation-reactive material; forming a spatially patterned beam of radiation using a patterned mask; exposing at least a portion of the target structure to the spatially patterned beam of radiation to which the radiation-reactive material reacts while leaving other portions of the target structure unexposed to the radiation; removing substantially all of one of the exposed or the unexposed patterned portions of the target structure to provide a plurality of non-contiguous structures that include at least a portion of the radiation-reactive material; and separating the plurality of non-contiguous structures comprising the radiation-reactive material from the substrate structure into a fluid material. Each non-contiguous structure of the radiation-reactive material provides at least a portion of a separate particle after the separation.
摘要翻译： 制造颗粒的方法包括提供包括固体基质的基底结构; 在所述衬底结构上形成目标结构，所述靶结构包括辐射反应性材料; 使用图案化掩模形成空间上图案化的辐射束; 将目标结构的至少一部分暴露于辐射反应性材料反应的空间图案化的辐射束，同时使目标结构的其它部分未暴露于辐射; 去除目标结构的暴露的或未曝光的图案化部分中的一个基本上全部，以提供包括至少一部分辐射反应性材料的多个非连续结构; 以及将包括所述辐射反应性材料的所述多个非连续结构与所述基底结构分离成流体材料。 辐射反应性材料的每个非连续结构在分离之后提供至少一部分单独的颗粒。
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3.发明申请公开(公告)号：US20100172831A1
公开(公告)日：2010-07-08
申请号：US12595800
申请日：2008-04-18
申请人： Thomas G. Mason , Connie B. Chang
发明人： Thomas G. Mason , Connie B. Chang
CPC分类号： A61K9/5184
摘要： A protein-modified droplet includes a droplet having a liquid material, and a protein structure formed to at least partially enclose the droplet. The protein structure includes a plurality of protein molecules having an affinity to at least a region of the droplet during formation of the protein structure, and the droplet has a maximum dimension of at least about 1 nm and less than about 1000 nm. A composition includes a plurality of protein-modified droplets dispersed in an aqueous solution.
摘要翻译： 蛋白质修饰的液滴包括具有液体材料的液滴和形成为至少部分地包围液滴的蛋白质结构。 蛋白质结构包括在形成蛋白质结构期间至少与液滴区域具有亲和性的多个蛋白质分子，并且液滴具有至少约1nm且小于约1000nm的最大尺寸。 组合物包含分散在水溶液中的多个蛋白质改性的液滴。
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公开(公告)号：US09073022B2
公开(公告)日：2015-07-07
申请号：US13259859
申请日：2010-04-22
申请人： Thomas G. Mason
发明人： Thomas G. Mason
CPC分类号： B01F3/0811
摘要： A system for producing emulsions includes a liquid supply system, an emulsification system in liquid connection with the liquid supply system to receive a first liquid and a second liquid from the liquid supply system while in operation to be used to produce an emulsion therefrom, and a surfactant recovery system connected to the emulsification system to receive the emulsion when produced from the first and second liquids. The second liquid is immiscible with the first liquid, and the surfactant recovery system recovers at least a portion of surfactant from the emulsion when the emulsion is received from the emulsification system.
摘要翻译： 用于生产乳液的系统包括液体供应系统，与液体供应系统液体连接以在液体供应系统中接收第一液体的乳化系统和来自液体供应系统的第二液体，同时在操作中用于从其生产乳液，以及 表面活性剂回收系统连接到乳化系统以在从第一和第二液体产生时接收乳液。 第二液体与第一液体不混溶，并且当从乳化系统接收乳液时，表面活性剂回收系统从乳液中回收至少一部分表面活性剂。
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公开(公告)号：US20120029093A1
公开(公告)日：2012-02-02
申请号：US13259859
申请日：2010-04-22
申请人： Thomas G. Mason
发明人： Thomas G. Mason
CPC分类号： B01F3/0811
摘要： A system for producing emulsions includes a liquid supply system, an emulsification system in liquid connection with the liquid supply system to receive a first liquid and a second liquid from the liquid supply system while in operation to be used to produce an emulsion therefrom, and a surfactant recovery system connected to the emulsification system to receive the emulsion when produced from the first and second liquids. The second liquid is immiscible with the first liquid, and the surfactant recovery system recovers at least a portion of surfactant from the emulsion when the emulsion is received from the emulsification system. A method of producing an emulsion includes providing first and second immiscible liquids, emulsifying the first and second liquids to provide an emulsion comprising a plurality of droplets of the first liquid in the second liquid, the emulsion having a first concentration of a surfactant, subjecting the emulsion to a change in an environmental condition that causes the surfactant to coalesce into localized regions of concentrated surfactant, and removing at least some of the localized regions of concentrated surfactant from the emulsion such that the emulsion has a second concentration of the surfactant that is less than the first concentration of the surfactant.
摘要翻译： 用于生产乳液的系统包括液体供应系统，与液体供应系统液体连接以在液体供应系统中接收第一液体的乳化系统和来自液体供应系统的第二液体，同时在操作中用于从其生产乳液，以及 表面活性剂回收系统连接到乳化系统以在从第一和第二液体产生时接收乳液。 第二液体与第一液体不混溶，并且当从乳化系统接收乳液时，表面活性剂回收系统从乳液中回收至少一部分表面活性剂。 制备乳液的方法包括提供第一和第二不混溶液体，乳化第一和第二液体以提供包含第二液体中的第一液体的多个液滴的乳液，所述乳液具有第一浓度的表面活性剂， 乳液使环境条件发生变化，导致表面活性剂聚结成浓缩表面活性剂的局部区域，并从乳液中除去浓缩表面活性剂的至少一些局部区域，使乳液具有较少的表面活性剂的第二浓度 比第一浓度的表面活性剂。
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公开(公告)号：US20110061786A1
公开(公告)日：2011-03-17
申请号：US12882731
申请日：2010-09-15
申请人： Thomas G. Mason
发明人： Thomas G. Mason
CPC分类号： G03F7/0002 , G03F7/00
摘要： A method of producing a particle includes fabricating a precursor particle structure that has a first sub-structure, a second sub-structure proximate the first sub-structure and an interconnecting sub-structure connected to the first and second sub-structures, the precursor particle structure being in a first configuration; and exposing the precursor particle structure to a stochastic excitation process to cause a deformation of the interconnecting sub-structure to reconfigure at least one of a position and an orientation of the first sub-structure relative to the second sub-structure from the first configuration to form the particle in a second configuration. The first sub-structure and the second sub-structure are substantially free of deformation during the exposing, and a maximal spatial dimension of the particle in the second configuration is less than about one millimeter. A multi-component composition has a first material component, and a plurality of particles produced according to methods of the current invention that are dispersed in the first material component. A maximal spatial dimension of each of the plurality of particles is less than about 10 micrometers, and the plurality of particles is at least 10 particles.
摘要翻译： 制造颗粒的方法包括制造具有第一子结构，靠近第一子结构的第二子结构和连接到第一和第二子结构的互连子结构的前体颗粒结构，前体颗粒 结构处于第一配置; 以及将所述前体颗粒结构暴露于随机激励过程以引起所述互连子结构的变形，以将所述第一子结构相对于所述第二子结构的位置和取向中的至少一个从所述第一配置重新配置为 在第二种构型中形成颗粒。 第一子结构和第二子结构在曝光期间基本上没有变形，并且第二构造中的颗粒的最大空间尺寸小于约一毫米。 多组分组合物具有分散在第一材料组分中的第一材料组分和根据本发明的方法制备的多个颗粒。 多个颗粒中的每一个的最大空间尺寸小于约10微米，并且多个颗粒为至少10个颗粒。
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公开(公告)号：US20100035061A1
公开(公告)日：2010-02-11
申请号：US12377773
申请日：2007-08-17
CPC分类号： G03F7/40 , B81C99/008 , B81C2201/038
摘要： A method of producing particles includes providing a substrate structure that comprises a solid substrate; forming a target structure on said substrate structure, said target structure comprising a radiation-reactive material; forming a spatially patterned beam of radiation using a patterned mask; exposing at least a portion of the target structure to the spatially patterned beam of radiation to which the radiation-reactive material reacts while leaving other portions of the target structure unexposed to the radiation; removing substantially all of one of the exposed or the unexposed patterned portions of the target structure to provide a plurality of non-contiguous structures that include at least a portion of the radiation-reactive material; and separating the plurality of non-contiguous structures comprising the radiation-reactive material from the substrate structure into a fluid material. Each non-contiguous structure of the radiation-reactive material provides at least a portion of a separate particle after the separation.
摘要翻译： 制造颗粒的方法包括提供包括固体基质的基底结构; 在所述衬底结构上形成目标结构，所述靶结构包括辐射反应性材料; 使用图案化掩模形成空间上图案化的辐射束; 将目标结构的至少一部分暴露于辐射反应性材料反应的空间图案化的辐射束，同时使目标结构的其它部分未暴露于辐射; 去除目标结构的暴露的或未曝光的图案化部分中的一个基本上全部，以提供包括至少一部分辐射反应性材料的多个非连续结构; 以及将包括所述辐射反应性材料的所述多个非连续结构与所述基底结构分离成流体材料。 辐射反应性材料的每个非连续结构在分离之后提供至少一部分单独的颗粒。
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公开(公告)号：US20130064759A1
公开(公告)日：2013-03-14
申请号：US13604465
申请日：2012-09-05
CPC分类号： A61K9/113 , A61K47/183 , A61K47/34 , B01F17/005 , B82Y5/00 , Y02A50/401 , Y10S977/773 , Y10S977/795 , Y10S977/906 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93 , Y10T428/2984
摘要： An emulsion includes a substantially continuous liquid medium, and a plurality of droplet structures dispersed within the substantially continuous liquid medium. Each droplet structure of the plurality of droplet structures includes an outer droplet of a first liquid having an outer surface; an inner droplet of a second liquid within the first droplet, the second liquid being immiscible in the first liquid, wherein the inner and outer droplets have a boundary surface region therebetween; an outer layer of block copolymers disposed on the outer surface of the outer droplet; and an inner layer of block copolymers disposed on the boundary surface region between the outer and the inner droplets.
摘要翻译： 乳液包括基本上连续的液体介质和分散在基本上连续的液体介质内的多个液滴结构。 多个液滴结构的每个液滴结构包括具有外表面的第一液体的外滴; 所述第一液滴内的第二液体的内部液滴，所述第二液体在所述第一液体中不混溶，其中所述内部和外部液滴在其间具有边界表面区域; 设置在外部液滴的外表面上的嵌段共聚物的外层; 以及设置在外液滴和内液滴之间的边界表面区域上的嵌段共聚物的内层。
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公开(公告)号：US08377307B2
公开(公告)日：2013-02-19
申请号：US12576089
申请日：2009-10-08
申请人： Thomas G. Mason
发明人： Thomas G. Mason
IPC分类号： B01D17/00
CPC分类号： G01N33/491 , B03C5/022 , B03C2201/26
摘要： A method of separating a mixture of discrete structures dispersed in a fluid material includes identifying a target structure and a non-target structure; providing a custom-shaped particle having at least a portion of a surface that is substantially shape-complementary to a portion of a surface of the target structure; introducing the custom-shaped particle into the fluid material; exciting reconfigurations of the custom-shaped particle with respect to the target structure and the non-target structure; binding the custom-shaped particle to the target structure through an attractive interaction to form an aggregate; and isolating the aggregate containing the target structure and the custom-shaped particle from the non-target structure. The custom-shaped particle preferentially binds with the target structure without binding with the non-target structure.
摘要翻译： 分离分散在流体材料中的离散结构的混合物的方法包括鉴定目标结构和非目标结构; 提供具有与目标结构的表面的一部分基本上形状互补的表面的至少一部分的定制形状的颗粒; 将定形颗粒引入流体材料中; 相对于目标结构和非目标结构，定制颗粒的激发重新配置; 通过有吸引力的相互作用将定形颗粒结合到目标结构以形成聚集体; 并从非目标结构中分离含有靶结构和定形颗粒的聚集体。 定制颗粒优先与靶结构结合而不与非目标结构结合。
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公开(公告)号：US20110223215A1
公开(公告)日：2011-09-15
申请号：US13129550
申请日：2009-12-02
申请人： Thomas G. Mason
发明人： Thomas G. Mason
CPC分类号： A61K9/0014 , A61K9/0021
摘要： A method of producing a topical scrub includes providing a particle material suitable for producing a customized anisotropic particle; producing a plurality of customized anisotropic particles composed of the particle material, each customized anisotropic particle having a particle shape, a particle volume, and a particle composition; and dispersing the plurality of customized anisotropic particles in a fluid material to form a dispersion of customized anisotropic particles in the fluid material. At least a feature of the particle shape facilitates embedding at least a portion of the plurality of customized anisotropic particles into a topical surface by a scrubbing action.
摘要翻译： 制备局部擦洗的方法包括提供适于制备定制的各向异性颗粒的颗粒材料; 生成由颗粒材料构成的多个定制各向异性粒子，每个定制的各向异性粒子具有粒子形状，粒子体积和粒子组成; 并将多个定制的各向异性粒子分散在流体材料中以形成流体材料中定制的各向异性粒子的分散体。 至少颗粒形状的特征便于通过洗涤作用将多个定制的各向异性颗粒的至少一部分嵌入到局部表面。
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