公开(公告)号：US08362082B2

公开(公告)日：2013-01-29

申请号：US13243242

申请日：2011-09-23

Applicant: Thibaud Biadatti ,  Etienne Thoreau

Inventor： Thibaud Biadatti ,  Etienne Thoreau

IPC: A01N37/10

CPC classification number: C07C65/26 ,  C07C51/09

Abstract: Biphenyl compounds having the formula (I): are useful for preventing/treating pathologies linked to a deficiency of the activation of the RAR gamma receptor, e.g., for treating a pathology linked to a cell differentiation and/or proliferation disorder, for treating acne, for treating psoriasis.

公开(公告)号：US08049034B2

公开(公告)日：2011-11-01

申请号：US12213177

申请日：2008-06-16

Applicant: Thibaud Biadatti ,  Etienne Thoreau

Inventor： Thibaud Biadatti ,  Etienne Thoreau

IPC: C07C63/33 ,  C07C62/00 ,  A01N37/10

CPC classification number: C07C65/26 ,  C07C51/09

Abstract: Biphenyl compounds having the formula (I): are useful for preventing/treating pathologies linked to a deficiency of the activation of the RAR gamma receptor, e.g., for treating a pathology linked to a cell differentiation and/or proliferation disorder, for treating acne, for treating psoriasis.

Abstract translation: 具有式（I）的联苯化合物可用于预防/治疗与RARγ受体活化缺陷相关的病症，例如用于治疗与细胞分化和/或增殖病症相关的病理学，用于治疗痤疮， 用于治疗牛皮癣。

公开(公告)号：US20050182144A1

公开(公告)日：2005-08-18

申请号：US11066795

申请日：2005-02-28

Applicant: Thibaud Biadatti ,  Etienne Thoreau ,  Johannes Voegel ,  Andre Jomard

Inventor： Thibaud Biadatti ,  Etienne Thoreau ,  Johannes Voegel ,  Andre Jomard

IPC: A61K8/34 ,  A61K8/46 ,  A61K8/67 ,  A61K8/69 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  C07C43/23 ,  A61K31/59 ,  A61K31/045 ,  C07C43/02

CPC classification number: A61K8/69 ,  A61K8/345 ,  A61K8/46 ,  A61K8/67 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  C07C43/23

Abstract: Novel biaromatic vitamin D analogues have the general formula (I): and are suited for a wide variety of pharmaceutical applications, whether in human or veterinary medicine, and also for cosmetic applications.

Abstract translation: 新型的双维维生素D类似物具有通式（I）：适用于各种各样的药物应用，无论是在人类或兽医学中，还适用于化妆品应用。

公开(公告)号：US20120016031A1

公开(公告)日：2012-01-19

申请号：US13243242

申请日：2011-09-23

Applicant: Thibaud BIADATTI ,  Etienne Thoreau

Inventor： Thibaud BIADATTI ,  Etienne Thoreau

IPC: A61K31/192 ,  A61P17/06 ,  A61P17/10 ,  C07C65/17 ,  A61P35/00

CPC classification number: C07C65/26 ,  C07C51/09

Abstract: Biphenyl compounds having the formula (I): are useful for preventing/treating pathologies linked to a deficiency of the activation of the RAR gamma receptor, e.g., for treating a pathology linked to a cell differentiation and/or proliferation disorder, for treating acne, for treating psoriasis.

Abstract translation: 具有式（I）的联苯化合物可用于预防/治疗与RARγ受体活化缺陷相关的病症，例如用于治疗与细胞分化和/或增殖病症相关的病理学，用于治疗痤疮， 用于治疗牛皮癣。

公开(公告)号：US20090036536A1

公开(公告)日：2009-02-05

申请号：US12213178

申请日：2008-06-16

Applicant: Thibaud Biadatti ,  Etienne Thoreau

Inventor： Thibaud Biadatti ,  Etienne Thoreau

IPC: A61K31/192 ,  C07C63/33 ,  A61P17/06 ,  A61P17/10

CPC classification number: C07C65/17 ,  C07C51/09 ,  C07C67/31 ,  C07C67/343 ,  C07C2602/10 ,  C07C69/76 ,  C07C69/94

Abstract: Biphenyl compounds having the formula (I): are useful for preventing/treating pathologies linked to a deficiency of the activation of the RAR gamma receptor, e.g., for treating a pathology linked to a cell differentiation and/or proliferation disorder, for treating acne, for treating psoriasis.

Abstract translation: 具有式（I）的联苯化合物可用于预防/治疗与RARγ受体活化缺陷相关的病症，例如用于治疗与细胞分化和/或增殖病症相关的病理学，用于治疗痤疮， 用于治疗牛皮癣。

公开(公告)号：US20090023811A1

公开(公告)日：2009-01-22

申请号：US12213177

申请日：2008-06-16

Applicant: Thibaud Biadatti ,  Etienne Thoreau

Inventor： Thibaud Biadatti ,  Etienne Thoreau

IPC: A61K31/192 ,  C07C65/01 ,  A61P35/00 ,  A61P17/00

CPC classification number: C07C65/26 ,  C07C51/09

Abstract: Biphenyl compounds having the formula (I): are useful for preventing/treating pathologies linked to a deficiency of the activation of the RAR gamma receptor, e.g., for treating a pathology linked to a cell differentiation and/or proliferation disorder, for treating acne, for treating psoriasis.

公开(公告)号：US08106235B2

公开(公告)日：2012-01-31

申请号：US12213178

申请日：2008-06-16

Applicant: Thibaud Biadatti ,  Etienne Thoreau

Inventor： Thibaud Biadatti ,  Etienne Thoreau

IPC: C07C63/33 ,  C07C62/00 ,  A01N37/10

CPC classification number: C07C65/17 ,  C07C51/09 ,  C07C67/31 ,  C07C67/343 ,  C07C2602/10 ,  C07C69/76 ,  C07C69/94

Abstract: Biphenyl compounds having the formula (I): are useful for preventing/treating pathologies linked to a deficiency of the activation of the RAR gamma receptor, e.g., for treating a pathology linked to a cell differentiation and/or proliferation disorder, for treating acne, for treating psoriasis.

Abstract translation: 具有式（I）的联苯化合物可用于预防/治疗与RARγ受体活化缺陷相关的病症，例如用于治疗与细胞分化和/或增殖病症相关的病理学，用于治疗痤疮， 用于治疗牛皮癣。

公开(公告)号：US07312249B2

公开(公告)日：2007-12-25

申请号：US11066795

申请日：2005-02-28

Applicant: Thibaud Biadatti ,  Etienne Thoreau ,  Johannes Voegel ,  Andre Jomard

Inventor： Thibaud Biadatti ,  Etienne Thoreau ,  Johannes Voegel ,  Andre Jomard

IPC: A61K31/59 ,  A61K31/45 ,  C07C43/02

CPC classification number: A61K8/69 ,  A61K8/345 ,  A61K8/46 ,  A61K8/67 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  C07C43/23

Abstract: Novel biaromatic vitamin D analogues have the general formula (I): and are suited for a wide variety of pharmaceutical applications, whether in human or veterinary medicine, and also for cosmetic applications.

Abstract translation: 新型的双维维生素D类似物具有通式（I）：适用于各种各样的药物应用，无论是在人类或兽医学中，还适用于化妆品应用。

公开(公告)号：US08022079B2

公开(公告)日：2011-09-20

申请号：US12562665

申请日：2009-09-18

Applicant: Laurence Clary ,  Etienne Thoreau ,  Michel Rivier ,  Jerome Aubert ,  Laurent Chantalat ,  Johannes Voegel

Inventor： Laurence Clary ,  Etienne Thoreau ,  Michel Rivier ,  Jerome Aubert ,  Laurent Chantalat ,  Johannes Voegel

IPC: A61K31/505 ,  A61K31/445 ,  A61K31/44 ,  A61K31/41 ,  A61K31/425 ,  A61K31/415 ,  A61K31/38 ,  A61K31/34 ,  C07D239/02 ,  C07D211/06 ,  C07D213/00 ,  C07D285/10 ,  C07D277/20 ,  C07D249/14 ,  C07D233/28 ,  C07D333/36 ,  C07D307/02

CPC classification number: C07D213/75 ,  C07D213/55 ,  C07D239/26 ,  C07D239/42 ,  C07D249/14 ,  C07D277/30 ,  C07D277/48 ,  C07D307/54 ,  C07D333/24 ,  C07D401/12 ,  C07D409/04 ,  C07D413/06 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12

Abstract: Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.

Abstract translation: 具有以下通式（I）的新型化合物可用于人或兽医学（在皮肤病学以及心血管疾病，免疫疾病和/或与脂质代谢相关的疾病领域）的广泛应用中，或 ，或者配制成化妆品组合物。

公开(公告)号：US07973063B2

公开(公告)日：2011-07-05

申请号：US12588267

申请日：2009-10-09

Applicant: Jerome Aubert ,  Laurence Clary ,  Pascale Mauvais ,  Michel Rivier ,  Etienne Thoreau ,  Jean-Guy Boiteau

Inventor： Jerome Aubert ,  Laurence Clary ,  Pascale Mauvais ,  Michel Rivier ,  Etienne Thoreau ,  Jean-Guy Boiteau

IPC: A61K31/425

CPC classification number: C07C275/42 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14

Abstract: Novel biaromatic compounds having the following structural formula (I): are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine, in particular in dermatology as well as in the fields of cardiovascular diseases, immune diseases and/or diseases related to the metabolism of lipids, or, alternatively, into cosmetic compositions.

Abstract translation: 具有以下结构式（I）的新颖的双芳族化合物被配制成适用于人或兽医药物，特别是皮肤病学以及心血管疾病，免疫疾病和/或代谢相关疾病领域的药物组合物 的脂质，或者替代为化妆品组合物。