公开(公告)号：US20200055815A1

公开(公告)日：2020-02-20

申请号：US16555673

申请日：2019-08-29

申请人： The University of North Carolina at Chapel Hill ,  Novan, Inc.

发明人： Mark Schoenfisch ,  Yuan Lu ,  Nathan Stasko ,  Jian Bao

IPC分类号： C07C281/20 ,  C07C247/10 ,  A61K31/655 ,  C07C291/02

摘要： Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.

公开(公告)号：US20190135738A1

公开(公告)日：2019-05-09

申请号：US16239069

申请日：2019-01-03

申请人： The University of North Carolina at Chapel Hill ,  Novan, Inc.

发明人： Mark Schoenfisch ,  Yuan Lu ,  Nathan Stasko ,  Jian Bao

IPC分类号： C07C281/20 ,  C07C247/10 ,  A61K31/655 ,  C07C291/02

CPC分类号： C07C281/20 ,  A61K31/655 ,  C07C247/10 ,  C07C291/02 ,  Y10T428/2982

摘要： Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.

公开(公告)号：US11124476B2

公开(公告)日：2021-09-21

申请号：US16555673

申请日：2019-08-29

申请人： The University of North Carolina at Chapel Hill ,  Novan, Inc.

发明人： Mark Schoenfisch ,  Yuan Lu ,  Nathan Stasko ,  Jian Bao

IPC分类号： C07C281/20 ,  A61K31/655 ,  A61K9/14 ,  C07C291/02 ,  C07C247/10

摘要： Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.

公开(公告)号：US20140171395A1

公开(公告)日：2014-06-19

申请号：US14184156

申请日：2014-02-19

申请人： The University of North Carolina at Chapel Hill ,  Novan, Inc.

发明人： Mark Schoenfisch ,  Yuan Lu ,  Nathan Stasko ,  Jian Bao

IPC分类号： A61K31/655 ,  C07C247/10 ,  C07C281/20

CPC分类号： C07C281/20 ,  A61K31/655 ,  C07C247/10 ,  C07C291/02 ,  Y10T428/2982

摘要： Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.

摘要翻译： 这里提供一氧化氮释放化合物，其包括相同类别的至少两种不同的NO供体官能团。 在一些实施方案中，这种释放氧化氮的化合物是大分子如树枝状聚合物和共缩合二氧化硅。 本文还提供药物组合物，伤口敷料，试剂盒和治疗方法。

公开(公告)号：US09713652B2

公开(公告)日：2017-07-25

申请号：US13975930

申请日：2013-08-26

申请人： Novan, Inc. ,  The University of North Carolina at Chapel Hill

发明人： Mark Schoenfisch ,  Daniel Riccio ,  Julia Nugent ,  Nathan Stasko

IPC分类号： C08K3/28 ,  C08K3/30 ,  B32B5/16 ,  A61L2/18 ,  C07F7/08 ,  C07F7/18 ,  C08G77/26 ,  C08G77/28 ,  C07F7/10 ,  C08K3/02

CPC分类号： A61L2/18 ,  C07F7/0874 ,  C07F7/10 ,  C07F7/1804 ,  C08G77/26 ,  C08G77/28 ,  C08K3/28 ,  C08K3/30 ,  C08K2003/023 ,  Y10T428/2982

摘要： Provided according to some embodiments of the invention are methods of forming co-condensed silica particles. In some embodiments, the methods include reacting a thiol-containing silane and a backbone alkoxysilane in a reaction solution that comprises water to form thiol-functionalized co-condensed silica particles, wherein the thiol-functionalized co-condensed silica particles include a polysiloxane matrix and at least some of thiol groups are present within the polysiloxane matrix; and reacting the thiol-functionalized co-condensed silica particles with a nitrosating agent to provide the S-nitrosothiol-functionalized co-condensed silica particles. In some embodiments, provided are S-nitrosothiol-functionalized co-condensed silica particles.

公开(公告)号：US20140134321A1

公开(公告)日：2014-05-15

申请号：US14022717

申请日：2013-09-10

申请人： The University of North Carolina at Chapel Hill ,  Novan, Inc.

发明人： Nathan Stasko ,  Mark Schoenfisch ,  Benjamin Privett ,  Jae Ho Shin ,  Wesley Storm

IPC分类号： A61K33/00

CPC分类号： A61K33/00 ,  C09D5/08 ,  C09D183/08 ,  Y10T428/31663

摘要： Provided according to embodiments of the invention are NO-releasing sol-gel coating formed from a sol precursor solution comprising a backbone alkoxysilane and a diazeniumdiolate-modified alkoxysilane. Further provided are methods of producing NO-releasing sol-gel coatings. Such methods may include (a) co-condensing a sol precursor solution comprising a backbone alkoxysilane and a diazeniumdiolate-modified alkoxysilane in a solvent to form a sol; (b) coating a substrate with the sol; and (c) drying the sol to form the NO-releasing sol-gel coating.

摘要翻译： 根据本发明的实施方案提供的是由包含骨架烷氧基硅烷和二氮烯二硫醇盐改性的烷氧基硅烷的溶胶前体溶液形成的释放NO的溶胶 - 凝胶涂层。 还提供了生产释放NO的溶胶 - 凝胶涂层的方法。 这样的方法可以包括（a）在溶剂中将包含骨架烷氧基硅烷和二氮烯鎓二硫醇盐改性的烷氧基硅烷的溶胶前体溶液共聚以形成溶胶; （b）用溶胶涂布基材; 和（c）干燥溶胶以形成释放NO的溶胶 - 凝胶涂层。

公开(公告)号：US20130344334A1

公开(公告)日：2013-12-26

申请号：US13975930

申请日：2013-08-26

申请人： The University of North Carolina at Chapel Hill ,  Novan, Inc.

发明人： Mark Schoenfisch ,  Daniel Riccio ,  Julia Nugent ,  Nathan Stasko

IPC分类号： C07F7/10

CPC分类号： A61L2/18 ,  C07F7/0874 ,  C07F7/10 ,  C07F7/1804 ,  C08G77/26 ,  C08G77/28 ,  C08K3/28 ,  C08K3/30 ,  C08K2003/023 ,  Y10T428/2982

摘要： Provided according to some embodiments of the invention are methods of forming co-condensed silica particles. In some embodiments, the methods include reacting a thiol-containing silane and a backbone alkoxysilane in a reaction solution that comprises water to form thiol-functionalized co-condensed silica particles, wherein the thiol-functionalized co-condensed silica particles include a polysiloxane matrix and at least some of thiol groups are present within the polysiloxane matrix; and reacting the thiol-functionalized co-condensed silica particles with a nitrosating agent to provide the S-nitrosothiol-functionalized co-condensed silica particles. In some embodiments, provided are S-nitrosothiol-functionalized co-condensed silica particles.

摘要翻译： 根据本发明的一些实施方案提供了形成共缩合二氧化硅颗粒的方法。 在一些实施方案中，所述方法包括在包含水以形成硫醇官能化的共缩合二氧化硅颗粒的反应溶液中使含硫醇的硅烷和骨架烷氧基硅烷反应，其中硫醇官能化的共缩合二氧化硅颗粒包括聚硅氧烷基质和 至少一些硫醇基团存在于聚硅氧烷基质内; 并使硫醇官能化的共缩合二氧化硅颗粒与亚硝化剂反应以提供S-亚硝基硫醇官能化的共缩合二氧化硅颗粒。 在一些实施方案中，提供了S-亚硝基硫醇官能化的共缩合二氧化硅颗粒。

公开(公告)号：US20210395191A1

公开(公告)日：2021-12-23

申请号：US17465929

申请日：2021-09-03

申请人： The University of North Carolina at Chapel Hill ,  Novan, Inc.

发明人： Mark Schoenfisch ,  Yuan Lu ,  Nathan Stasko ,  Jian Bao

IPC分类号： C07C281/20 ,  C07C291/02 ,  A61K31/655 ,  C07C247/10

摘要： Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.

公开(公告)号：US10435357B2

公开(公告)日：2019-10-08

申请号：US16239069

申请日：2019-01-03

申请人： The University of North Carolina at Chapel Hill ,  Novan, Inc.

发明人： Mark Schoenfisch ,  Yuan Lu ,  Nathan Stasko ,  Jian Bao

IPC分类号： C07C281/20 ,  A61K31/655 ,  A61K9/14 ,  C07C291/02 ,  C07C247/10

摘要： Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.

公开(公告)号：US10196349B2

公开(公告)日：2019-02-05

申请号：US14961133

申请日：2015-12-07

申请人： The University of North Carolina at Chapel Hill ,  Novan, Inc.

发明人： Mark Schoenfisch ,  Yuan Lu ,  Nathan Stasko ,  Jian Bao

IPC分类号： C07C281/20 ,  A61K31/655 ,  A61K9/14 ,  C07C291/02 ,  C07C247/10

摘要： Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.