-
公开(公告)号：US20170114406A1
公开(公告)日：2017-04-27
申请号：US15312909
申请日：2015-05-22
发明人： Carl Lars, Genghis HANSEN , Georgia Elizabeth MEWIS , Kevin Albert HEYRIES , Michael Andrew VANINSBERGHE , Daniel Jay DA COSTA , Marketa RICICOVA
CPC分类号： C12Q1/6876 , C07K14/7051 , C12Q2600/158 , C40B20/00 , C40B30/04 , G01N33/68 , G16B30/00 , G16B40/00 , C12Q2535/122
摘要： Provided herein are high-throughput sequencing methods to study the diversity and functionality of lymphocyte receptor chains and pairing of the same. Specifically, the methods provided herein are used to identify with confidence one or more lymphocyte receptor chain pairs in a sample, for example one or more functional chain pairs.
-
公开(公告)号：US20190300954A1
公开(公告)日：2019-10-03
申请号：US16423861
申请日：2019-05-28
发明人： Carl Lars Genghis HANSEN , Georgia Elizabeth MEWIS , Kevin Albert HEYRIES , Michael Andrew VANINSBERGHE , Daniel Jay DA COSTA , Marketa RICICOVA
IPC分类号： C12Q1/6876 , G16B40/00 , G16B30/00 , C07K14/725 , C40B20/00 , G01N33/68
摘要： Provided herein are high-throughput sequencing methods to study the diversity and functionality of lymphocyte receptor chains and pairing of the same. Specifically, the methods provided herein are used to identify with confidence one or more lymphocyte receptor chain pairs in a sample, for example one or more functional chain pairs.
-
公开(公告)号：US20230041481A1
公开(公告)日：2023-02-09
申请号：US17835220
申请日：2022-06-08
发明人： Carl Lars Genghis HANSEN , Georgia Elizabeth MEWIS , Kevin Albert HEYRIES , Michael Andrew VANINSBERGHE , Daniel Jay DA COSTA , Marketa RICICOVA
IPC分类号： C40B30/04 , G16B30/00 , G16B40/00 , C40B20/00 , G01N33/68 , C07K14/725 , G16B30/20 , G16B30/10 , C12Q1/6876
摘要： Provided herein are high-throughput sequencing methods to study the diversity and functionality of lymphocyte receptor chains and pairing of the same. Specifically, the methods provided herein are used to identify with confidence one or more lymphocyte receptor chain pairs in a sample, for example one or more functional chain pairs.
-
4.发明申请公开(公告)号：US20210269792A1
公开(公告)日：2021-09-02
申请号：US17321645
申请日：2021-05-17
发明人： Ester FALCONER , Carl Lars Genghis HANSEN , Veronique LECAULT , Kathleen LISAINGO , Kevin Albert HEYRIES
IPC分类号： C12N15/10 , C12Q1/6874 , G01N33/566 , G01N33/68
摘要： The present invention relates to methods for isolating the sequences of an antibody that reacts with a disease related antigen, e.g., an autoantigen, without knowing the identity of the antigen (sequence or structural epitope) a priori. The methods can also be used to identify an antigen that mediates a disease state, e.g., an autoantigen implicated in an autoimmune disorder or a tumor response.
-
公开(公告)号：US20220365072A1
公开(公告)日：2022-11-17
申请号：US17369425
申请日：2021-07-07
发明人： Marketa RICICOVA , Kevin Albert HEYRIES , Hans ZAHN , Oleh PETRIV , Veronique LECAULT , Anupam Singhal , Daniel J. Da Costa , Carl L. G. Hansen , Brad NELSON , Julie NIELSEN , Kathleen Lisaingo
IPC分类号： G01N33/50 , B01L3/00 , C07K16/40 , G01N33/543 , C07K16/10 , C07K16/00 , C12N5/078 , C12N5/0781 , C12Q1/6888 , G01N33/68 , G01N35/00
摘要： Methods and devices are provided herein for identifying a cell population comprising an effector cell that exerts an extracellular effect. In one embodiment the method comprises retaining in a microreactor a cell population comprising one or more effector cells, wherein the contents of the microreactor further comprise a readout particle population comprising one or more readout particles, incubating the cell population and the readout particle population within the microreactor, assaying the cell population for the presence of the extracellular effect, wherein the readout particle population or subpopulation thereof provides a direct or indirect readout of the extracellular effect, and determining, based on the results of the assaying step, whether one or more effector cells within the cell population exerts the extracellular effect on the readout particle. If an extracellular effect is measured, the cell population is recovered for further analysis to determine the cell or cells responsible for the effect.
-
6.发明申请公开(公告)号：US20200149031A1
公开(公告)日：2020-05-14
申请号：US16063394
申请日：2016-12-21
发明人： Ester FALCONER , Carl Lars Genghis HANSEN , Veronique LECAULT , Kathleen LISAINGO , Kevin Albert HEYRIES
IPC分类号： C12N15/10 , G01N33/566 , G01N33/68 , C12Q1/6874
摘要： The present invention relates to methods for isolating the sequences of an antibody that reacts with a disease related antigen, e.g., an autoantigen, without knowing the identity of the antigen (sequence or structural epitope) a priori. The methods can also be used to identify an antigen that mediates a disease state, e.g., an autoantigen implicated in an autoimmune disorder or a tumor response.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.015 秒)
