公开(公告)号：US20230144866A1

公开(公告)日：2023-05-11

申请号：US18054586

申请日：2022-11-11

Applicant: The Trustees of the University of Pennsylvania

Inventor： Zhiliang Cheng ,  Andrew Tsourkas ,  Ling Qin

IPC: A61K38/44 ,  A61K9/127 ,  A61P39/06 ,  A61P9/02 ,  A61P19/02

CPC classification number: A61K38/446 ,  A61K9/1273 ,  A61P39/06 ,  A61P9/02 ,  A61P19/02

Abstract: Therapeutic compositions, comprising: an anti-reactive oxygen species agent and a pervious polymersome, the pervious polymersome encapsulating the anti-reactive oxygen species agent, and the pervious polymersome having therein channels defined by a channel diblock copolymer, the channels being arranged so as to retain at least some of the anti-reactive oxygen species agent within the pervious polymersome while allowing reactive oxygen species to pass into the pervious polymersome.
Method of treating a patient, comprising: administering an effective amount of a therapeutic composition, the therapeutic composition comprising an anti-reactive oxygen species agent disposed within a pervious polymersome, the pervious polymersome encapsulating the anti-reactive oxygen species agent, and the pervious polymersome having therein channels defined by a channel diblock copolymer, the channels being arranged so as to retain at least some of the anti-reactive oxygen species agent within the pervious polymersome while allowing reactive oxygen species to pass into the pervious polymersome.

公开(公告)号：US11446391B2

公开(公告)日：2022-09-20

申请号：US16628739

申请日：2018-07-05

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Inventor： Andrew Tsourkas ,  Jayesh Thawani ,  Ahmad Amirshaghaghi ,  Lesan Yan ,  Zhiliang Cheng

IPC: A61K47/69 ,  A61K41/00 ,  A61K49/00 ,  A61K49/18 ,  A61P35/04 ,  A61K9/00 ,  A61K9/107

Abstract: The invention relates to amphiphilic dye-coated inorganic nanoparticle clusters and uses thereof. Specifically, the invention relates to cyanine and/or cyclic tetrapyrrole dye-coated metallic nanoparticle clusters for use in medical imaging and treatments.