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公开(公告)号：US11913026B2
公开(公告)日：2024-02-27
申请号：US16821933
申请日：2020-03-17
Inventor： Andrew Tsourkas , James Z. Hui , Burcin Altun , Fabiana Zappala
CPC classification number: C12N5/0638 , A61P35/00 , C07K16/2809 , C07K16/2827 , C07K16/3015 , A61K2039/507 , C07K2317/622 , C12N2510/00
Abstract: A bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibody comprising a cytotoxic lymphocyte or macrophage targeting domain and an autoantibody. Methods for producing bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibody comprising a cytotoxic lymphocyte or macrophage targeting domain and an autoantibody. Methods for treating a subject in need thereof comprising administering to the subject an isolated bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibody.
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公开(公告)号：US11236177B2
公开(公告)日：2022-02-01
申请号：US16333196
申请日：2017-09-14
Inventor： Andrew Tsourkas , Burcin Altun , Hejia Henry Wang , Feifan Yu
Abstract: The invention relates to proximity-based sortase-mediated protein purification and ligation. Specifically, the invention relates to techniques that links protein expression/purification with conjugation to therapeutic agents, imaging agents, or linkers.
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公开(公告)号：US11377481B2
公开(公告)日：2022-07-05
申请号：US16064875
申请日：2016-12-21
Inventor： Daniel Powell , Andrew Tsourkas
IPC: C07K14/725 , C07K14/705 , A61K35/17
Abstract: The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor that comprises a protein or peptide tag, such as a SpyCatcher or a SpyTag moiety, bound to an extracellular hinge region, a transmembrane domain, and an intracellular domain for T cell activation.
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公开(公告)号：US11156608B2
公开(公告)日：2021-10-26
申请号：US14774883
申请日：2014-03-17
Inventor： Andrew Tsourkas , James Z. Hui
IPC: C07K14/31 , A61K47/68 , C07K16/46 , C12N15/62 , A61K39/00 , G01N33/543 , A61K49/18 , C07K17/00 , A61K47/65 , A61K47/62 , C07K17/06 , G01N33/58
Abstract: This invention relates to conjugate antibody, drug and nanoparticle compositions and methods of generating the same. This invention further relates to methods of using same for imaging, diagnosing or treating a disease.
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公开(公告)号：US09631218B2
公开(公告)日：2017-04-25
申请号：US14774986
申请日：2014-03-17
Inventor： Andrew Tsourkas , Robert Warden-Rothman
CPC classification number: C12P21/06 , C07K1/22 , C07K2319/21 , C12P21/02
Abstract: The invention relates to a sortase-mediated protein purification and ligation. Specifically, the invention relates to a technique that links protein expression/purification with conjugation to therapeutic agents, imaging agents, or linkers.
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Patent Agency Ranking
公开(公告)号：US20230046047A1
公开(公告)日：2023-02-16
申请号：US17411815
申请日：2021-08-25
Inventor： Andrew Tsourkas , James Z. Hui
Abstract: The invention relates to antibody conjugates (e.g., a bispecific antibody), drug and nanoparticle compositions and methods and compositions for generating them. This invention further relates to methods of using these compositions for imaging, diagnosing or treating a disease.
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公开(公告)号：US11446391B2
公开(公告)日：2022-09-20
申请号：US16628739
申请日：2018-07-05
Inventor： Andrew Tsourkas , Jayesh Thawani , Ahmad Amirshaghaghi , Lesan Yan , Zhiliang Cheng
Abstract: The invention relates to amphiphilic dye-coated inorganic nanoparticle clusters and uses thereof. Specifically, the invention relates to cyanine and/or cyclic tetrapyrrole dye-coated metallic nanoparticle clusters for use in medical imaging and treatments.
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公开(公告)号：US11337665B2
公开(公告)日：2022-05-24
申请号：US14776232
申请日：2014-03-13
Inventor： Andrew D. A. Maidment , Anatoliy V. Popov , E. James Delikatny , Andrew Tsourkas , Roshan Karunamuni , Ajlan Al Zaki , Sara Gavenonis , David Cormode
Abstract: Contrast agents for x-ray imaging including stabilized metal nanoparticles and encapsulated nanoparticles, as well as methods for imaging tissue with these agents, are disclosed. Also disclosed are methods of dual energy x-ray imaging using metal nanoparticle contrast agents or encapsulated metal nanoparticles.
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公开(公告)号：US20210138088A1
公开(公告)日：2021-05-13
申请号：US17116596
申请日：2020-12-09
Inventor： David Peter Cormode , Pratap Chandra Naha , Andrew Tsourkas , Ajlan Al Zaki
Abstract: Nanoparticles for use as a contrast agent, and methods for making and using the nanoparticles, are described, wherein each nanoparticle comprises a core comprising bismuth and iron oxide, and an outer coating (e.g., dextran) surrounding the core. The bismuth-iron oxide nanoparticles can be used in pre-clinical and clinical settings for both computed tomography (CT) and magnetic resonance (MR) imaging.
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公开(公告)号：US20220265234A1
公开(公告)日：2022-08-25
申请号：US17711156
申请日：2022-04-01
Inventor： Andrew D.A. Maidment , Anatoliy V. Popov , E James Delikatny , Andrew Tsourkas , Roshan Karunamuni , Ajlan Al Zaki , Sara Gavenonis , fDavid Cormode
Abstract: Contrast agents for x-ray imaging including stabilized metal nanoparticles and encapsulated nanoparticles, as well as methods for imaging tissue with these agents, are disclosed. Also disclosed are methods of dual energy x-ray imaging using metal nanoparticle contrast agents or encapsulated metal nanoparticles.
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