公开(公告)号：US20190307878A1

公开(公告)日：2019-10-10

申请号：US16408517

申请日：2019-05-10

Applicant: The Rockefeller University

Inventor： Jeffrey V. Ravetch ,  Taia Wang ,  Jad Mamaary

IPC: A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  A61K39/42 ,  A61K45/06 ,  C07K16/10 ,  A61P35/00 ,  C07K14/005 ,  C07K14/47 ,  A61P31/16

Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods.

公开(公告)号：US20230338505A1

公开(公告)日：2023-10-26

申请号：US18319865

申请日：2023-05-18

Applicant: The Rockefeller University

Inventor： Jeffrey V. Ravetch ,  Taia Wang ,  Jad Mamaary

IPC: A61K39/145 ,  A61K39/42 ,  A61K39/12 ,  C07K16/10 ,  A61P31/16 ,  A61P35/00 ,  A61K39/00 ,  A61K45/06 ,  C07K14/005 ,  C07K14/47

CPC classification number: A61K39/145 ,  A61K39/42 ,  A61K39/12 ,  C07K16/1018 ,  A61P31/16 ,  A61P35/00 ,  A61K39/0011 ,  A61K45/06 ,  C07K14/005 ,  C07K14/4748 ,  A61K2039/5252 ,  A61K2039/55516 ,  C12N2760/16134 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/92 ,  C07K2317/72 ,  C07K2317/76

Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods.

公开(公告)号：US20210228706A1

公开(公告)日：2021-07-29

申请号：US17301626

申请日：2021-04-09

Applicant: The Rockefeller University

Inventor： Jeffrey V. Ravetch ,  Taia Wang ,  Jad Mamaary

IPC: A61K39/145 ,  A61K39/42 ,  A61K39/12 ,  C07K16/10 ,  A61P31/16 ,  A61P35/00 ,  A61K39/00 ,  A61K45/06 ,  C07K14/005 ,  C07K14/47

Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods.

公开(公告)号：US12186385B2

公开(公告)日：2025-01-07

申请号：US18319865

申请日：2023-05-18

Applicant: The Rockefeller University

Inventor： Jeffrey V. Ravetch ,  Taia Wang ,  Jad Mamaary

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/42 ,  A61K45/06 ,  A61P31/16 ,  A61P35/00 ,  C07K14/005 ,  C07K14/47 ,  C07K16/00 ,  C07K16/08 ,  C07K16/10 ,  C07K16/12 ,  C07K16/30

Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods.

公开(公告)号：US11690905B2

公开(公告)日：2023-07-04

申请号：US17301626

申请日：2021-04-09

Applicant: The Rockefeller University

Inventor： Jeffrey V. Ravetch ,  Taia Wang ,  Jad Mamaary

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/42 ,  C07K14/005 ,  C07K16/00 ,  C07K16/08 ,  C07K16/12 ,  C07K16/30 ,  A61K39/145 ,  C07K16/10 ,  A61P31/16 ,  A61P35/00 ,  A61K45/06 ,  C07K14/47

CPC classification number: A61K39/145 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/42 ,  A61K45/06 ,  A61P31/16 ,  A61P35/00 ,  C07K14/005 ,  C07K14/4748 ,  C07K16/1018 ,  A61K2039/505 ,  A61K2039/5252 ,  A61K2039/55516 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2760/16134 ,  A61K39/42 ,  A61K2300/00

Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods.

公开(公告)号：US10973904B2

公开(公告)日：2021-04-13

申请号：US16408517

申请日：2019-05-10

Applicant: The Rockefeller University

Inventor： Jeffrey V. Ravetch ,  Taia Wang ,  Jad Mamaary

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/42 ,  C07K14/005 ,  C07K16/00 ,  C07K16/08 ,  C07K16/12 ,  C07K16/30 ,  A61K39/145 ,  C07K16/10 ,  A61P31/16 ,  A61P35/00 ,  A61K45/06 ,  C07K14/47

Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods.

公开(公告)号：US10300127B2

公开(公告)日：2019-05-28

申请号：US15560074

申请日：2016-03-21

Applicant: The Rockefeller University

Inventor： Jeffrey V. Ravetch ,  Taia Wang ,  Jad Mamaary

IPC: A61K39/42 ,  A61K39/12 ,  A61K39/145 ,  C07K16/10 ,  A61P31/16 ,  A61P35/00 ,  A61K39/00 ,  A61K45/06 ,  C07K14/005 ,  C07K14/47

Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods. This invention addresses the above-described un-met need by providing an immune complex (IC) or immune complexes (ICs), which take advantages of Type II Fc receptor (FcR) interactions and signaling to elicit broader and more potent protective immune responses. In one aspect, the invention provides an immune complex comprising an antigenic agent and an isolated protein. The protein comprises an IgG Fc region and is capable of binding to a Type II Fc receptor. Preferably, the protein is an antibody or an Fc region-containing fragment thereof.

公开(公告)号：US20180117139A1

公开(公告)日：2018-05-03

申请号：US15560074

申请日：2016-03-21

Applicant: The Rockefeller University

Inventor： Jeffrey V. Ravetch ,  Taia Wang ,  Jad Mamaary

IPC: A61K39/145 ,  C07K16/10 ,  C07K14/005 ,  C07K14/47 ,  A61K39/42 ,  A61K39/00 ,  A61K45/06 ,  A61P31/16 ,  A61P35/00

CPC classification number: A61K39/145 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/5252 ,  A61K2039/55516 ,  A61P31/16 ,  A61P35/00 ,  C07K14/005 ,  C07K14/4748 ,  C07K16/1018 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2760/16134 ,  A61K2300/00

Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods. This invention addresses the above-described un-met need by providing an immune complex (IC) or immune complexes (ICs), which take advantages of Type II Fc receptor (FcR) interactions and signaling to elicit broader and more potent protective immune responses. In one aspect, the invention provides an immune complex comprising an antigenic agent and an isolated protein. The protein comprises an IgG Fc region and is capable of binding to a Type II Fc receptor. Preferably, the protein is an antibody or an Fc region-containing fragment thereof.