公开(公告)号：US20150305632A1

公开(公告)日：2015-10-29

申请号：US14675062

申请日：2015-03-31

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Kayvan Najarian ,  Kenn Oldham ,  Daniel Slavin ,  Ashwin Belle ,  Kevin R. Ward ,  Sardar Ansari ,  Rodney C. Daniels

IPC: A61B5/0295 ,  A61M5/172 ,  A61B5/021 ,  A61B5/02 ,  A61B5/0205 ,  A61B5/024

CPC classification number: A61B5/0295 ,  A61B5/02007 ,  A61B5/02438 ,  A61B5/11 ,  A61B5/6802 ,  A61B5/6831 ,  A61B5/7207 ,  A61B5/7235 ,  A61B2562/0261 ,  A61B2562/06 ,  A61M5/1723

Abstract: The invention is a passive, wearable sensor that uses a thin piezoelectric material to produce a time history of blood pressure of the patient, with signal processing algorithms to extract physiological information. The sensor consists of a piezoelectric transducer set in a polymer laminate that can be applied to the finger or wrist of the patient. During use, a combination of compressive and bending deformation in the piezoelectric layer in response to blood pressure in the finger or wrist as a voltage output. Using signal processing techniques, the raw signal is filtered and decomposed to obtain a information to form derivative signals such as blood pressure, pulse pressure, pulse pressure variability, heart rate, heart rate variability, and respiratory rate which can be very important pre-cursors in the monitoring of the patient's physiological conditions.

Abstract translation: 本发明是一种被动的，可穿戴的传感器，其使用薄的压电材料来产生患者血压的时间历史，具有信号处理算法来提取生理信息。 该传感器由设置在聚合物层压板中的压电传感器组成，可以应用于患者的手指或手腕。 在使用期间，响应于手指或手腕中的血压作为电压输出，压电层中的压缩和弯曲变形的组合。 使用信号处理技术，对原始信号进行滤波和分解，得到一个信息，以形成诸如血压，脉搏压力，脉搏压力变异性，心率，心率变异性和呼吸频率等导数信号，这可能是非常重要的预游标 在监测患者的生理状况。

公开(公告)号：US20250010045A1

公开(公告)日：2025-01-09

申请号：US18890252

申请日：2024-09-19

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Rodney C. Daniels ,  Ashwin Belle

IPC: A61M27/00 ,  A61B5/00 ,  A61B5/03

Abstract: A dependent closed pressure vessel is fluidly coupled to an independent closed pressure vessel. A pressure sensor monitors pressure in the vessels to generate raw pressure measurement data. A flow meter monitors multidirectional rate of flow of fluid between the vessels and the volume of fluid flowing from the independent closed pressure vessel to generate raw rate of flow and raw volume measurement data. A pressure/flow regulator valve adjusts pressure in the dependent closed pressure vessel in response to a pressure set point signal generated in response to the raw pressure data, adjusts the rate of flow of fluid between the vessels in response to a rate of flow set point signal generated in response to the raw rate of flow data, and adjusts the rate of flow of fluid between the vessels in response to a volume set point signal generated in response to the raw volume data.

公开(公告)号：US20200297982A1

公开(公告)日：2020-09-24

申请号：US16765618

申请日：2018-11-20

Applicant: The Regents of the University of Michigan

Inventor： Rodney C. Daniels ,  Ashwin Belle

IPC: A61M27/00 ,  A61B5/03 ,  A61B5/00

Abstract: A dependent closed pressure vessel is fluidly coupled to an independent closed pressure vessel. A pressure sensor monitors pressure in the vessels to generate raw pressure measurement data. A flow meter monitors multidirectional rate of flow of fluid between the vessels and the volume of fluid flowing from the independent closed pressure vessel to generate raw rate of flow and raw volume measurement data. A pressure/flow regulator valve adjusts pressure in the dependent closed pressure vessel in response to a pressure set point signal generated in response to the raw pressure data, adjusts the rate of flow of fluid between the vessels in response to a rate of flow set point signal generated in response to the raw rate of flow data, and adjusts the rate of flow of fluid between the vessels in response to a volume set point signal generated in response to the raw volume data.

公开(公告)号：US10969379B2

公开(公告)日：2021-04-06

申请号：US16564917

申请日：2019-09-09

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  Virginia Commonwealth University

Inventor： Rodney C. Daniels ,  Kevin R. Ward ,  Maryanne M. Collinson

IPC: G01N27/327 ,  G01N33/49 ,  B01L3/00 ,  G01N27/30 ,  G01N33/487

Abstract: A bioelectrochemical sensor utilizing a nanoporous gold electrode. The bioelectrochemical sensor is suitable for measuring redox in biologic media while having increased resistance to biofouling as compared to conventional electrodes such as planar gold electrodes, due to greater exposed surface area of the three-dimensional ligature structure defining the nanopores. The nanopores have a pore size of 5-100 nm, preferably with an average pore size of less than 50 nm, and more preferably with an average pore size of less than 20 nm.

公开(公告)号：US20200003754A1

公开(公告)日：2020-01-02

申请号：US16564917

申请日：2019-09-09

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  Virginia Commonwealth University

Inventor： Rodney C. Daniels ,  Kevin R. Ward ,  Maryanne M. Collinson

IPC: G01N33/49 ,  B01L3/00 ,  G01N27/30 ,  G01N27/327 ,  G01N33/487

Abstract: A bioelectrochemical sensor utilizing a nanoporous gold electrode. The bioelectrochemical sensor is suitable for measuring redox in biologic media while having increased resistance to biofouling as compared to conventional electrodes such as planar gold electrodes, due to greater exposed surface area of the three-dimensional ligature structure defining the nanopores. The nanopores have a pore size of 5-100 nm, preferably with an average pore size of less than 50 nm, and more preferably with an average pore size of less than 20 nm.

公开(公告)号：US12109378B2

公开(公告)日：2024-10-08

申请号：US16765618

申请日：2018-11-20

Applicant: The Regents of the University of Michigan

Inventor： Rodney C. Daniels ,  Ashwin Belle

IPC: A61M27/00 ,  A61B5/00 ,  A61B5/03

CPC classification number: A61M27/006 ,  A61B5/0022 ,  A61B5/031 ,  A61B5/032 ,  A61M2205/18 ,  A61M2205/3337 ,  A61M2205/3584

Abstract: A dependent closed pressure vessel is fluidly coupled to an independent closed pressure vessel. A pressure sensor monitors pressure in the vessels to generate raw pressure measurement data. A flow meter monitors multidirectional rate of flow of fluid between the vessels and the volume of fluid flowing from the independent closed pressure vessel to generate raw rate of flow and raw volume measurement data. A pressure/flow regulator valve adjusts pressure in the dependent closed pressure vessel in response to a pressure set point signal generated in response to the raw pressure data, adjusts the rate of flow of fluid between the vessels in response to a rate of flow set point signal generated in response to the raw rate of flow data, and adjusts the rate of flow of fluid between the vessels in response to a volume set point signal generated in response to the raw volume data.

公开(公告)号：US10451606B2

公开(公告)日：2019-10-22

申请号：US15030958

申请日：2014-10-21

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Rodney C. Daniels ,  Kevin R. Ward ,  Maryanne M. Collinson

IPC: G01N27/30 ,  G01N33/49 ,  G01N27/327 ,  B01L3/00 ,  G01N33/487

Abstract: A bioelectrochemical sensor utilizing a nanoporous gold electrode. The bioelectrochemical sensor is suitable for measuring redox in biologic media while having increased resistance to biofouling as compared to conventional electrodes such as planar gold electrodes, due to greater exposed surface area of the three-dimentional ligature structure defining the nanopores. The nanopores have a pore size of 5-100 nm, preferably with an average pore size of less than 50 nm, and more preferably with an average pore size of less than 20 nm.

公开(公告)号：US20160266090A1

公开(公告)日：2016-09-15

申请号：US15030958

申请日：2014-10-21

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Rodney C. Daniels ,  Kevin R. Ward ,  Maryanne M. Collinson

IPC: G01N33/49 ,  G01N27/30 ,  G01N27/327 ,  G01N33/487 ,  B01L3/00

CPC classification number: G01N33/49 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0896 ,  B01L2300/12 ,  G01N27/301 ,  G01N27/307 ,  G01N27/3272 ,  G01N27/3277 ,  G01N27/3278 ,  G01N33/48707 ,  G01N2800/7009

Abstract: A bioelectrochemical sensor utilizing a nanoporous gold electrode. The bioelectrochemical sensor is suitable for measuring redox in biologic media while having increased resistance to biofouling as compared to conventional electrodes such as planar gold electrodes, due to greater exposed surface area of the three-dimentional ligature structure defining the nanopores. The nanopores have a pore size of 5-100 nm, preferably with an average pore size of less than 50 nm, and more preferably with an average pore size of less than 20 nm.

Abstract translation: 利用纳米多孔金电极的生物电化学传感器。 生物电化学传感器适用于测量生物介质中的氧化还原，同时与常规电极如平面金电极相比，具有增加的抗生物污损性，因为限定纳米孔的三维结扎结构的暴露表面积更大。 纳米孔具有5-100nm的孔径，优选平均孔径小于50nm，更优选平均孔径小于20nm。