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公开(公告)号：US20230381141A1
公开(公告)日：2023-11-30
申请号：US18178266
申请日：2023-03-03
发明人： Varghese John , Robert Damoiseaux , Melody Li , Barbara Jagodzinska , Jesus J. Campagna , Constance Yuen , Pablo Alvarez
IPC分类号： A61K31/4152 , A61K31/404 , A61K31/403 , A61K31/427
CPC分类号： A61K31/4152 , A61K31/404 , A61K31/403 , A61K31/427
摘要： The present disclosure relates to methods of treating coronavirus diseases comprising conjointly administering a combination of a PLpro inhibitor and an Mpro inhibitor, and to associated compositions.
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公开(公告)号：US20240174625A1
公开(公告)日：2024-05-30
申请号：US18277522
申请日：2022-02-18
发明人： Daniel H. Geschwind , Michael E. Jung , Liting Deng , Flora Hinz , Jennifer M. Murphy , Gaoyuan Ma , Robert Damoiseaux
IPC分类号： C07D275/04 , A61P25/28 , C07D213/74 , C07D217/22 , C07D239/42 , C07D239/94 , C07D261/20 , C07D417/04 , C07D417/12 , C07D513/04
CPC分类号： C07D275/04 , A61P25/28 , C07D213/74 , C07D217/22 , C07D239/42 , C07D239/94 , C07D261/20 , C07D417/04 , C07D417/12 , C07D513/04
摘要： Disclosed are compounds and methods for treating tauopathy.
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公开(公告)号：US10913750B2
公开(公告)日：2021-02-09
申请号：US16573602
申请日：2019-09-17
发明人： Jorge Torres , Robert Damoiseaux , Todd O. Yeates , Silvia Senese , Dan E. McNamara , Yu-Chen Lo
IPC分类号： C07D417/06 , A61P35/00 , C07D495/04 , C07D471/04 , C07D487/04 , C07D277/64
摘要： This disclosure relates to methods of treating cancer (e.g., melanoma) with (MI-181).
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公开(公告)号：US10730848B2
公开(公告)日：2020-08-04
申请号：US14801247
申请日：2015-07-16
发明人： Eugene Gillespie , Robert Damoiseaux , Chi-Lee Charlie Ho , Brian T. Chamberlain , Michael E. Jung , Kenneth A. Bradley
IPC分类号： C07D333/28 , C07C281/14 , C07C335/26 , C07D213/53 , C07D307/56 , C07C281/18 , C07C337/08 , C07D231/12 , C07C243/22 , C07C311/08 , C07D307/52 , C07D333/22
摘要： Disclosed herein inter alia are compositions and methods useful in the treatment of infectious diseases and exposure to toxins.
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公开(公告)号：US20200079789A1
公开(公告)日：2020-03-12
申请号：US16573602
申请日：2019-09-17
发明人： Jorge Torres , Robert Damoiseaux , Todd O. Yeates , Silvia Senese , Dan E. McNamara , Yu-Chen Lo
IPC分类号： C07D495/04 , C07D471/04 , C07D487/04 , C07D277/64 , C07D417/06 , A61P35/00
摘要： This disclosure relates to antimitotic compounds, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers and myelodysplastic syndromes.
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公开(公告)号：US20180354966A1
公开(公告)日：2018-12-13
申请号：US15577551
申请日：2016-05-26
发明人： Jorge Torres , Robert Damoiseaux , Todd O. Yeates , Silvia Senese , Dan E. McNamara , Yu-Chen Lo
IPC分类号： C07D495/04 , A61P35/00
CPC分类号： C07D495/04 , A61P35/00 , C07D277/64 , C07D417/06 , C07D471/04 , C07D487/04
摘要： This disclosure relates to antimitotic compounds, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers and myelodysplastic syndromes.
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公开(公告)号：US20150051251A1
公开(公告)日：2015-02-19
申请号：US14387212
申请日：2013-03-15
发明人： Richard A. Gatti , Liutao Du , Hailiang Hu , Robert Damoiseaux , Michael E. Jung , Jin-Mo Ku , Gladys Completo
IPC分类号： C07D401/04 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14
摘要： Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.
摘要翻译： 提供了早熟终止密码子，其通过复合物，其组合，及其制备和使用方法。
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公开(公告)号：US20230257732A1
公开(公告)日：2023-08-17
申请号：US18006382
申请日：2021-08-04
发明人： Mark van Zee , Dino Di Carlo , Joseph de Rutte , Sohyung Lee , Robert Damoiseaux , Cayden Williamson
CPC分类号： C12N11/04 , C12N5/0012 , C12N5/00 , C12N1/12 , C12N11/10 , C12N2537/10 , C12N2539/10 , C12N2509/00 , C12N2533/50 , C12N2533/70
摘要： Degradable hollow shell particles are disclosed that can encapsulate cells within the hollow inner cavity that allows for the high-throughput screening and sorting of the encapsulated cells based on their phenotypic properties. The solid-phase of the particle is porous such that solution exchange can occur between the external environment and the interior cavity. Further, the solid-phase contains degradable crosslinkers and can be degraded to release enclosed biological entities. An example embodiment consists of encapsulating a cell within the hollow shell particle, allowing the cell to accumulate biomass, selecting hollow shell particles based on accumulated biomass, and degrading the hollow shell particles to release the cells and develop hyper-producing cell lines. Exemplary cell types include microalgae, mammalian cells, bacteria, yeast, and fungi.
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公开(公告)号：US09255088B2
公开(公告)日：2016-02-09
申请号：US13764748
申请日：2013-02-11
发明人： Richard Gatti , Liutao Du , Robert Damoiseaux , Chih-Hung Lai , Michael Jung , Jin-Mo Ku , Carmen Bertoni
IPC分类号： C07D413/06 , C07D307/52 , C07C251/24 , C07C215/76 , C07C335/16 , C07D407/06 , C07D221/16 , C07D285/12 , C07D207/273 , C07D409/06 , C07C207/04 , C07C291/04
CPC分类号： C07D413/06 , C07C207/04 , C07C215/76 , C07C251/24 , C07C291/04 , C07C335/16 , C07D207/273 , C07D221/16 , C07D285/12 , C07D307/52 , C07D407/06 , C07D409/06
摘要： Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.
摘要翻译： 提供了早熟终止密码子，其通过复合物，其组合，及其制备和使用方法。
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公开(公告)号：US20230190736A1
公开(公告)日：2023-06-22
申请号：US17917445
申请日：2021-04-09
发明人： Vaithilingaraja Arumugaswami , Heather R. Christofk , Robert Damoiseaux , Gustavo Garcia , Peter Mullen , Brigitte N. Gomperts
IPC分类号： A61K31/497 , A61K45/06 , A61P31/14 , A61K31/5377 , A61K31/436 , A61K31/4706
CPC分类号： A61K31/497 , A61K45/06 , A61P31/14 , A61K31/5377 , A61K31/436 , A61K31/4706
摘要： This disclosure relates to methods of treating viral infections, such as influenza or coronavirus, with certain inhibitors, such as kinase inhibitors.
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