专利检索 ap:("The Regents of the University of California") AND inv:"Neil Pravin Shah" 第 1 页

1.

发明申请
MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571 审中-公开

公开(公告)号：US20190144946A1

公开(公告)日：2019-05-16

申请号：US15977810

申请日：2018-05-11

申请人： The Regents of the University of California

发明人： Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll

IPC分类号： C12Q1/6886 , C12Q1/48 , C07K14/82 , G01N33/574

摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.

2.

发明申请
MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571 有权
标题翻译：与STI-571相关的BCR-ABL酪氨酸激酶相关突变

公开(公告)号：US20160130655A1

公开(公告)日：2016-05-12

申请号：US14738630

申请日：2015-06-12

申请人： The Regents of the University of California

发明人： Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll

IPC分类号： C12Q1/68 , G01N33/574

CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52

摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bu-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.

摘要翻译： 本文描述的本发明涉及新型基因及其编码的蛋白质，称为与STI-571（例如，T315I Bu-Abl）的抗性相关的突变体，以及可用于管理表达MARS的各种癌症的诊断和治疗方法和组合物。本发明还提供用于鉴定结合和/或调节MARS的功能活性的分子的方法。

3.

发明申请
FLT3 MUTATIONS ASSOCIATED WITH DRUG RESISTANCE IN AML PATIENTS HAVING ACTIVATING MUTATIONS IN FLT3 审中-公开
标题翻译：与FLT3中的激活突变相关的FLT3突变与抗药性相关

公开(公告)号：US20140242590A1

公开(公告)日：2014-08-28

申请号：US14354462

申请日：2012-10-26

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Neil Pravin Shah , Catherine Choy Smith

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/156

摘要： The invention provides methods and compositions for identifying acute myeloid leukemia (AML) patients that have an increased likelihood of a relapse following treatment with AC 220.

摘要翻译： 本发明提供用于鉴定急性骨髓性白血病（AML）患者的方法和组合物，其在AC 220处理后具有增加的复发可能性。

4.

发明授权
Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571 有权

公开(公告)号：US09994910B2

公开(公告)日：2018-06-12

申请号：US14738630

申请日：2015-06-12

申请人： The Regents of the University of California

发明人： Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll

IPC分类号： C12Q1/68 , G01N33/574 , C07K14/82 , C12Q1/48

CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52

摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bu-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.