- 专利标题： Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571
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申请号： US14738630申请日： 2015-06-12
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公开(公告)号： US09994910B2公开(公告)日： 2018-06-12
- 发明人: Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll
- 申请人： The Regents of the University of California
- 申请人地址： US CA Oakland
- 专利权人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 当前专利权人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 当前专利权人地址： US CA Oakland
- 代理机构： Hunton Andrews Kurth LLP
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/574 ; C07K14/82 ; C12Q1/48
摘要：
The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bu-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
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