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1.发明申请Lysosomal Phospholipase A2 (LPLA2) Activity as a Diagnostic and Therapeutic Target for Identifying and Treating Systemic Lupus Erythematosus 审中-公开溶酶体磷脂酶A2（LPLA2）作为鉴定和治疗系统性红斑狼疮的诊断和治疗靶标的活性公开(公告)号：US20160317626A1
公开(公告)日：2016-11-03
申请号：US15095685
申请日：2016-04-11
发明人： James A. Shayman , Akira Abe , Robert Kelly , Jessica Kollmeyer , Ye Lu
CPC分类号： A61K38/45 , A61K38/465 , C12Q1/44 , C12Y203/01 , C12Y301/01005 , G01N33/6854 , G01N2333/91051 , G01N2333/918 , G01N2800/104 , G01N2800/56
摘要： The present invention is directed to methods for diagnosis and treatment of systemic lupus erythematosus and drug-induced systemic lupus erythematosus. More specifically, the specification describes methods using a lysosomal phospholipase A2 in methods for the diagnosis and treatment of autoimmune disorders such as systemic lupus erythematosus and drug-induced systemic lupus erythematosus.
摘要翻译： 本发明涉及用于诊断和治疗系统性红斑狼疮和药物诱发的系统性红斑狼疮的方法。 更具体地，本说明书描述了在诊断和治疗诸如系统性红斑狼疮和药物诱发的系统性红斑狼疮的自身免疫疾病的方法中使用溶酶体磷脂酶A2的方法。
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2.发明申请公开(公告)号：US20130095089A1
公开(公告)日：2013-04-18
申请号：US13652016
申请日：2012-10-15
发明人： Scott Larsen , Akira Abe , Liming Shu , Michael William Wilson , Richard F. Keep , James A. Shayman
IPC分类号： A61K31/4025 , C07D207/09 , A61K31/40 , A61P25/16 , A61P25/00 , A61K48/00 , A61P7/06 , A61P35/00 , A61P13/12 , A61P9/10 , A61P31/00 , A61K38/43 , C07D405/10 , A61P3/10
CPC分类号： A61K45/06 , A61K31/40 , C07D295/125 , C07D295/135 , C07D319/18 , A61K2300/00
摘要： Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
摘要翻译： 披露了葡糖基神经酰胺合成酶抑制剂及其组合物。 还公开了使用葡萄糖神经酰胺合成酶抑制剂治疗其中抑制葡萄糖神经酰胺合酶有益的疾病和病症的方法，如戈谢病和法布里病。
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公开(公告)号：US20180022697A1
公开(公告)日：2018-01-25
申请号：US15546320
申请日：2016-02-01
发明人： Scott D. Larsen , Akira Abe , Liming Shu , Michael William Wilson , Richard F. Keep , Duxin Sun , James A. Shayman
IPC分类号： C07D207/06 , C07D263/20 , C07D207/10 , C07D295/13 , C07D205/04
CPC分类号： C07D207/06 , A61K31/4015 , C07D205/04 , C07D207/04 , C07D207/09 , C07D207/10 , C07D263/20 , C07D263/24 , C07D295/125 , C07D295/13
摘要： Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
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4.发明授权公开(公告)号：US08961959B2
公开(公告)日：2015-02-24
申请号：US13652016
申请日：2012-10-15
发明人： Scott Larsen , Akira Abe , Liming Shu , Michael William Wilson , Richard F. Keep , James A. Shayman
IPC分类号： A61K38/43 , A01N43/36 , A61K31/40 , A61K48/00 , A01N33/18 , A01N33/24 , A61K31/045 , C07D405/00 , C07D207/08 , C07D207/46 , C07D295/04 , A61K45/06 , C07D319/18 , C07D295/125 , C07D295/135
CPC分类号： A61K45/06 , A61K31/40 , C07D295/125 , C07D295/135 , C07D319/18 , A61K2300/00
摘要： Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
摘要翻译： 披露了葡糖基神经酰胺合成酶抑制剂及其组合物。 还公开了使用葡萄糖神经酰胺合成酶抑制剂治疗其中抑制葡萄糖神经酰胺合酶有益的疾病和病症的方法，如戈谢病和法布里病。
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公开(公告)号：US10202340B2
公开(公告)日：2019-02-12
申请号：US15546320
申请日：2016-02-01
发明人： Scott D. Larsen , Akira Abe , Liming Shu , Michael William Wilson , Richard F. Keep , Duxin Sun , James A. Shayman
IPC分类号： A61K31/4015 , C07D207/06 , C07D263/20 , C07D207/04 , C07D263/24 , C07D205/04 , C07D207/09 , C07D207/10 , C07D295/125 , C07D295/13
摘要： Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
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公开(公告)号：US10111937B2
公开(公告)日：2018-10-30
申请号：US15095685
申请日：2016-04-11
发明人： James A. Shayman , Akira Abe , Robert Kelly , Jessica Kollmeyer , Ye Lu
IPC分类号： C07K14/755 , A61K38/45 , C12Q1/44 , A61K38/46 , G01N33/68
摘要： The present invention is directed to methods for diagnosis and treatment of systemic lupus erythematosus and drug-induced systemic lupus erythematosus. More specifically, the specification describes methods using a lysosomal phospholipase A2 in methods for the diagnosis and treatment of autoimmune disorders such as systemic lupus erythematosus and drug-induced systemic lupus erythematosus.
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