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    Numb protein expression inhibitors by Musashi
    2.
    发明授权
    Numb protein expression inhibitors by Musashi 有权
    Musashi的Numb蛋白表达抑制剂

    公开(公告)号：US07264793B2

    公开(公告)日：2007-09-04

    申请号：US10343311

    申请日：2001-11-22

    申请人： Takao Imai ,  Akinori Tokunaga ,  Tetsu Yoshida ,  Katsuhiko Mikoshiba ,  Masato Nakafuku ,  Hideyuki Okano

    发明人： Takao Imai ,  Akinori Tokunaga ,  Tetsu Yoshida ,  Katsuhiko Mikoshiba ,  Masato Nakafuku ,  Hideyuki Okano

    IPC分类号： A61K49/00 ,  A61K38/00 ,  C12P21/06 ,  C12N5/00 ,  C12N15/00 ,  C12N15/63

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： An Numb protein expression inhibitor comprising, as active ingredient, Musashi protein, a polypeptide having an amino acid sequence obtained by replacement, deletion, addition or insertion of at least one amino acid in an amino acid sequence of Musashi protein, or a gene encoding said polypeptide.By the present invention, a new function of Musashi protein has been elucidated. Described specifically, Musashi protein inhibits expression of Numb protein having a neuronal differentiation regulating function and potentiates the activity of the Notch signaling system, so that Musashi protein can be used as a therapeutic for various diseases of the central nervous system.

    摘要翻译： 一种Numb蛋白质表达抑制剂，其包含Musashi蛋白质作为活性成分的具有通过在Musashi蛋白质的氨基酸序列中替换，缺失，添加或插入至少一个氨基酸而获得的氨基酸序列的多肽，或编码所述 多肽。 通过本发明，已经阐明了Musashi蛋白质的新功能。 具体地说，Musashi蛋白抑制具有神经元分化调节功能的Numb蛋白的表达，并增强Notch信号系统的活性，使得Musashi蛋白可以用作中枢神经系统各种疾病的治疗剂。

    Automatic operating systems of machine tools and method
    3.
    发明授权
    Automatic operating systems of machine tools and method 失效
    自动操作系统的机床和方法

    公开(公告)号：US4249243A

    公开(公告)日：1981-02-03

    申请号：US955173

    申请日：1978-10-26

    申请人： Tetsu Yoshida ,  Isao Morimoto

    发明人： Tetsu Yoshida ,  Isao Morimoto

    IPC分类号： B23Q3/155 ,  B23Q41/00 ,  G05B19/4065 ,  G06F15/46

    CPC分类号： B23Q3/15526 ,  B23Q41/00 ,  G05B19/4065 ,  G05B2219/36044 ,  G05B2219/37245 ,  G05B2219/45051 ,  G05B2219/45083 ,  G05B2219/50249

    摘要： While machining a workpiece with a tool of a machine tool according to a numerically controlled machining program, when the tool breaks, the workpiece is removed from the machine tool and a new workpiece is substituted. A new program for the new workpiece is selected and a new tool for machining the new workpiece is selected and substituted for the broken tool. Now the new workpiece is machined in accordance with a new program. The workpieces removed from the machine tool are collected, fragments of the broken tools are removed therefrom, and then machined again. A tool magazine containing a plurality of tools is provided. Broken tools are removed from the machine tool and returned to the tool magazine. When all tools in the tool magazine are judged to be broken, new tools of the same type are supplemented. When the tools are worn out similar steps are executed.

    摘要翻译： 根据数控加工程序使用机床刀具加工工件时，刀具断裂时，工件从机床上移除，新工件被替换。 选择新工件的新程序，选择用于加工新工件的新工具，代替破损刀具。 现在新工件按照新程序加工。 从机床上取出的工件被收集，破碎的工具的碎片被从中移除，然后再次加工。 提供了包含多个工具的工具箱。 破碎的工具从机床上移除并返回到刀库。 当刀库中的所有刀具被判断为破损时，补充相同类型的新刀具。 当工具磨损时，执行类似的步骤。

    Numerical controlled machine tool making intermediate measurements
    4.
    发明授权
    Numerical controlled machine tool making intermediate measurements 失效
    数控机床进行中间测量

    公开(公告)号：US4583159A

    公开(公告)日：1986-04-15

    申请号：US494558

    申请日：1983-05-13

    申请人： Masakazu Kanemoto ,  Tetsu Yoshida ,  Fumio Kamahora

    发明人： Masakazu Kanemoto ,  Tetsu Yoshida ,  Fumio Kamahora

    IPC分类号： B23Q15/22 ,  B23Q15/00 ,  B23Q17/22 ,  B23Q35/00 ,  G05B19/18 ,  G05B19/401 ,  G06F15/00 ,  G05B19/00

    CPC分类号： G05B19/182 ,  G05B19/401 ,  G05B2219/37207 ,  G05B2219/37405 ,  G05B2219/49113 ,  G05B2219/50063 ,  G05B2219/50249 ,  G05B2219/50252

    摘要： A numerical controlled machine tool apparatus capable of providing intermediate measurement (in process measurement) during the carrying out of a machining process on a workpiece. A spindle of the apparatus, usually used for mounting a machining tool, is also capable of mounting a measuring tool which generates a contact signal when the measuring tool on the spindle is brought into contact with the workpiece. A measuring control unit including a memory is capable of compensating for any deviation that may exist between a center axis line of the measuring tool and the center axis line of the spindle, thereby making the apparatus capable of carrying out accurate measurements and adjusting a machining process based on the result of such an accurate measurement.

    摘要翻译： 一种能够在对工件进行加工过程中提供中间测量（过程测量）的数控机床设备。 通常用于安装加工工具的设备的主轴也能够安装测量工具，当主轴上的测量工具与工件接触时，该测量工具产生接触信号。 包括存储器的测量控制单元能够补偿测量工具的中心轴线与主轴的中心轴线之间可能存在的任何偏差，从而使设备能够进行准确的测量并调整加工过程 基于这样精确测量的结果。

    Machining systems and control systems therefor
    5.
    发明授权
    Machining systems and control systems therefor 失效
    加工系统及其控制系统

    公开(公告)号：US4473883A

    公开(公告)日：1984-09-25

    申请号：US247868

    申请日：1981-03-26

    申请人： Tetsu Yoshida ,  Isao Morimoto

    发明人： Tetsu Yoshida ,  Isao Morimoto

    IPC分类号： B23Q41/00 ,  G05B19/418 ,  G06F15/46

    CPC分类号： G05B19/418 ,  G05B19/4189 ,  G05B2219/32002 ,  G05B2219/32003 ,  G05B2219/32047 ,  G05B2219/32048 ,  G05B2219/32252 ,  G05B2219/37196 ,  G05B2219/50099 ,  Y02P90/20 ,  Y02P90/28 ,  Y10T483/165

    摘要： A machining system includes machine tools each capable of performing, in a working area thereof, machining on a workpiece carried on a pallet, a pallet magazine including movable stations each capable of carrying and conveying a pallet and having pallet change positions each associated with each of the machine tools, pallet changers each associated with each of the machine tools and each capable of transferring a pallet between the working area of the associated machine tool and the associated pallet change position, numerical control devices each associated with each of the machine tools and each capable of storing part programs and of controlling the associated machine tool, and a system controller comprising first memory for storing, in relation to each of schedule numbers indicating order of machining, an indicium of a pallet carrying a workpiece to be machined in the related order and an indicium of a part program to be used for machining the related pallet, and second memory for storing, in relation to an indicium of each of the pallets, and indicium of the movable station carrying the related pallet.

    摘要翻译： 一种加工系统包括机床，其能够在其工作区域中对在托盘上承载的工件进行机械加工，托盘盒包括各自能够承载和输送托盘的托架托盘，并且具有每个托盘改变位置 机床，托盘交换器，每个与每个机床相关联，并且每个都能够在相关联的机床的工作区域和相关联的托盘更换位置之间传送托盘，每个与每个机床相关联的数字控制装置和每个 能够存储零件程序和控制相关联的机床的系统控制器，以及系统控制器，其包括第一存储器，用于相对于指示加工顺序的每个表格数据存储托盘，该托盘以相关顺序运送待加工的工件 以及用于加工相关托盘的零件程序的标记和用于的相关托盘的第二存储器 相对于每个托盘的标记和携带相关托盘的可移动台的标记存储。

    Method and apparatus for measuring a workpiece
    6.
    发明授权
    Method and apparatus for measuring a workpiece 失效
    用于测量工件的方法和装置

    公开(公告)号：US4484118A

    公开(公告)日：1984-11-20

    申请号：US384278

    申请日：1982-06-02

    申请人： Takao Manabe ,  Fumio Kamahora ,  Tetsu Yoshida ,  Masakazu Kanemoto

    发明人： Takao Manabe ,  Fumio Kamahora ,  Tetsu Yoshida ,  Masakazu Kanemoto

    IPC分类号： G01B7/02 ,  G05B19/401 ,  G05B13/00

    CPC分类号： G05B19/401 ,  G01B7/023 ,  G05B2219/37207 ,  G05B2219/37405

    摘要： A numerical controlled machine tool provides a detector which produces a detecting signal when it is brought into contact or out of contact with a workpiece for measuring same. A driving device relatively moves the detector with respect to the workpiece, and a position detecting means for detecting the position of the detector. The numerical control device provides a signal corresponding to an amount by which the detector is moved with respect to the workpiece and causes the driving device to stop in accordance with the detecting signal. In operation, the numerical control device detects when the detector contacts with the workpiece while moving at a first speed, and applies a stop signal which is produced from a detecting signal given by the detector. The detector is then moved in a direction away from the workpiece at a second speed by a distance which is either larger or smaller than the distance by which the detector moved and stopped after the first detecting signal was produced. The detector is then further relatively moved either away from or towards, respectively, the workpiece at a third speed smaller than the first and second speeds. A detecting signal is again produced when the detector is brought into contact with the workpiece while moving at the third speed, and the contents of the position detecting device are read out when the detecting signal is produced while moving at the third speed is read out.

    摘要翻译： 数控机床提供了一种检测器，当检测信号与工件接触或不与其接触以产生检测信号，以便进行测量。 驱动装置相对于工件相对地移动检测器，以及位置检测装置，用于检测检测器的位置。 数字控制装置提供对应于检测器相对于工件移动的量的信号，并使驱动装置根据检测信号停止。 在操作中，数字控制装置检测在第一速度移动时检测器与工件何时接触，并且施加由检测器给出的检测信号产生的停止信号。 然后将检测器沿着远离工件的方向以第二速度移动距离，该距离大于或小于在产生第一检测信号之后检测器移动和停止的距离。 然后，检测器以比第一和第二速度小的第三速度进一步相对移动或远离工件。 当在第三速度移动时检测器与工件接触时再次产生检测信号，并且读出在以第三速度移动时产生检测信号时位置检测装置的内容。