公开(公告)号：US20150086447A1

公开(公告)日：2015-03-26

申请号：US14524685

申请日：2014-10-27

Applicant: Gregory Mathus ,  Terrence Kelly ,  Richard Cote

Inventor： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

IPC: B01L3/02

CPC classification number: B01L3/0217 ,  B01L3/0275 ,  B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2300/027 ,  Y10T137/0318 ,  Y10T436/2575

Abstract: The pipetting method is directed to mounting and ejecting a disposable pipette tip. The pipetting system has one or more tip mounting shafts with an upper locking section and a lower sealing section. The upper locking section has outwardly extending lobes spaced around the mounting shaft and located above a stop member. The lower sealing section on the tip mounting shaft is located below the stop. As the mounting shaft is inserted into the collar of the disposable pipette, the collar distorts out of round and engages the lobes on the upper locking section of the tip mounting shaft. Contemporaneously, the lower sealing section of the mounting shaft seals against the barrel of the disposable pipette tip.

Abstract translation: 移液方法涉及安装和喷射一次性吸头。 移液系统具有一个或多个具有上部锁定部分和下部密封部分的尖端安装轴。 上锁定部分具有围绕安装轴间隔开并位于止动件上方的向外延伸的凸角。 刀片安装轴上的下密封部分位于挡块下方。 当安装轴插入到一次性移液管的轴环中时，套环从圆形变形并与尖端安装轴的上部锁定部分上的凸角接合。 同时，安装轴的下密封部分密封在一次性移液管尖端的筒体上。

公开(公告)号：US20100034706A1

公开(公告)日：2010-02-11

申请号：US12578714

申请日：2009-10-14

Applicant: Gregory Mathus ,  Terrence Kelly ,  Richard Cote

Inventor： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

IPC: B01L3/02

CPC classification number: B01L3/0217 ,  B01L3/0275 ,  B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2300/027 ,  Y10T137/0318 ,  Y10T436/2575

Abstract: In one aspect, the invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft includes a locking section located above a lower sealing section. The locking section has outwardly extending locking lobes located above a stop member and a lower sealing section located below the stop member. In certain embodiments, the diameter of the mounting shaft below the stop member is reduced in order to lessen insertion and ejection forces, which is particularly helpful for hand-held multi-channel pipettors. In these embodiments, the lower sealing section contains either a frustoconical sealing section, or an annular groove and a sealing ring, such as a flouroelastomeric O-ring seal. When the mounting shaft is fully inserted into the collar of the mating disposable pipette tip, the tip locks onto the mounting shaft. The bore of the pipette tip includes a circumferential shelf or shoulder separating its upper collar from the tip sealing area which is located below the circumferential shelf. The tip collar preferably includes a locking ring located at or near the upper opening for the mounting shaft. The dimensions of the collar, and in particular the distance between its circumferential shelf and the locking ring, are selected to match the dimensions of the mounting shaft between the stop member and the upper end of the locking lobes, thus locking the pipette tip in a secure, reliable position and orientation while using ergonomic insertion and ejection forces. The locking lobes preferably include a ramp portion that gently flexes and distorts the pipette tip collar out of round as the mounting shaft is inserted in the pipette tip, rather than stretching the tip collar. The circumferential shelf on the pipette tip between the tip collar and the barrel isolates the sealing area at the upper end of the barrel from distortion, thus facilitating reliable sealing engagement between the lower sealing section of the mounting shaft and the sealing ring in the upper end of the barrel of the pipette tip.

公开(公告)号：US20080286157A1

公开(公告)日：2008-11-20

申请号：US11934381

申请日：2007-11-02

Applicant: Gregory Mathus ,  Terrence Kelly ,  Richard Cote

Inventor： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

IPC: B01L3/02

CPC classification number: B01L3/0217 ,  B01L3/0275 ,  B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2300/027 ,  Y10T137/0318 ,  Y10T436/2575

Abstract: In one aspect, the invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft includes a locking section located above a lower sealing section. The locking section has outwardly extending locking lobes located above a stop member and a lower sealing section located below the stop member. In certain embodiments, the diameter of the mounting shaft below the stop member is reduced in order to lessen insertion and ejection forces, which is particularly helpful for hand-held multi-channel pipettors. In these embodiments, the lower sealing section contains either a frustoconical sealing section, or an annular groove and a sealing ring, such as a flouroelastomeric O-ring seal. When the mounting shaft is fully inserted into the collar of the mating disposable pipette tip, the tip locks onto the mounting shaft. The bore of the pipette tip includes a circumferential shelf or shoulder separating its upper collar from the tip sealing area which is located below the circumferential shelf. The tip collar preferably includes a locking ring located at or near the upper opening for the mounting shaft. The dimensions of the collar, and in particular the distance between its circumferential shelf and the locking ring, are selected to match the dimensions of the mounting shaft between the stop member and the upper end of the locking lobes, thus locking the pipette tip in a secure, reliable position and orientation while using ergonomic insertion and ejection forces. The locking lobes preferably include a ramp portion that gently flexes and distorts the pipette tip collar out of round as the mounting shaft is inserted in the pipette tip, rather than stretching the tip collar. The circumferential shelf on the pipette tip between the tip collar and the barrel isolates the sealing area at the upper end of the barrel from distortion, thus facilitating reliable sealing engagement between the lower sealing section of the mounting shaft and the sealing ring in the upper end of the barrel of the pipette tip.

公开(公告)号：US07662343B2

公开(公告)日：2010-02-16

申请号：US11552384

申请日：2006-10-24

Applicant: Gregory Mathus ,  Terrence Kelly ,  Richard Cote

Inventor： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

IPC: B01L3/02

CPC classification number: B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/087

Abstract: The invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft includes a locking section located above a lower sealing section. The locking section has outwardly extending locking lobes circumferentially spaced around the mounting shaft and located above a stop member that separates the lower sealing section from the upper locking section. When the mounting shaft is fully inserted into the collar of the mating disposable pipette tip, the tip locks onto the mounting shaft. The bore of the pipette tip includes a circumferential shelf separating its upper collar from the tip sealing area which is located below the circumferential shelf. The locking lobes gently flexes and distorts the pipette tip collar out of round as the mounting shaft is inserted in the pipette tip, rather than stretching the tip collar. The circumferential shelf on the pipette tip between the tip collar and the barrel isolates the sealing area at the upper end of the barrel from distortion, thus facilitating reliable sealing engagement.

Abstract translation: 本发明涉及移液器吸头安装轴构造和具有匹配构型的一次性吸头。 安装轴包括位于下密封部分上方的锁定部分。 锁定部分具有沿安装轴周向间隔开的向外延伸的锁定凸角，并且位于将下部密封部分与上部锁定部分分离的止挡部件上方。 当安装轴完全插入到匹配的一次性移液管尖端的轴环中时，尖端锁定在安装轴上。 移液管尖端的孔包括将其上部套环与位于周向架下方的尖端密封区域分开的周向架。 当安装轴插入移液管尖端时，锁定凸耳轻轻地弯曲和扭曲移液管尖端套环，而不是拉伸尖端套环。 吸头尖端在圆顶架和圆筒之间的圆周架子隔开了筒体上端的密封区域，使其不会变形，从而有利于可靠的密封接合。

公开(公告)号：US08501118B2

公开(公告)日：2013-08-06

申请号：US12578714

申请日：2009-10-14

Applicant: Gregory Mathus ,  Terrence Kelly ,  Richard Cote

Inventor： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

IPC: B01L3/02

CPC classification number: B01L3/0217 ,  B01L3/0275 ,  B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2300/027 ,  Y10T137/0318 ,  Y10T436/2575

Abstract: A disposable pipette tip having that is configured to mount on a tip mounting shaft having a locking section and a separate sealing section. The locking section has outwardly extending locking lobes circumferentially spaced around the mounting shaft and located above a stop member that separates the lower sealing section from the upper locking section. The collar flexes out of round when it is mounted over the locking lobes on the mounting shaft. The circumferential shelf on the tip isolates the tip barrel from distortion to enable robust sealing in the barrel below the shelf.

Abstract translation: 具有该移液管尖头的一次性移液管尖端配置成安装在具有锁定部分和单独的密封部分的尖端安装轴上。 锁定部分具有沿安装轴周向间隔开的向外延伸的锁定凸角，并且位于将下部密封部分与上部锁定部分分离的止挡部件上方。 当套环安装在安装轴上的锁定凸角上时，套环会弹出。 尖端的圆周架子将尖端筒体分离，以防止变形，从而能够在机架下方的筒体上牢固地密封。

公开(公告)号：US20110076205A1

公开(公告)日：2011-03-31

申请号：US12568801

申请日：2009-09-29

Applicant: Terrence Kelly ,  Richard Cote ,  Gregory Mathus

Inventor： Terrence Kelly ,  Richard Cote ,  Gregory Mathus

IPC: B01L3/02

CPC classification number: B01L3/0279 ,  B01L3/021 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2400/0487

Abstract: A pipette tip mounting shaft includes outwardly circumferentially extending locking lobes over which the pipette tip collar is mounted. The locking lobes preferably include an inclining ramp portion that gently flexes and distorts the pipette tip collar out-of-round as the mounting shaft is inserted into the pipette tip, rather than the stretching tip collar. Each locking lobe also includes a declining ramp portion which extends upward along the mounting shaft. The peak of the lobes is preferably curved. When the pipette tip is fully mounted on the mounting shaft, a locking ring on the inside surface of the tip collar engages the declining ramp of the lobes to provide an over-center engagement, however, the required ejection force is small.

Abstract translation: 移液管尖端安装轴包括向外周向延伸的锁定凸耳，移液管尖端套环安装在该凸起上。 锁定凸耳优选地包括倾斜斜面部分，当倾斜安装轴插入移液管尖端而不是拉伸尖端套环时，倾斜斜坡部分轻轻地弯曲和扭曲移液管尖端轴环。 每个锁定凸耳还包括沿安装轴向上延伸的下降斜面部分。 裂片的峰最好是弯曲的。 当移液管末端完全安装在安装轴上时，尖端套环的内表面上的锁定环接合凸角的下降斜面以提供过中心接合，然而，所需的弹出力很小。

公开(公告)号：US07662344B2

公开(公告)日：2010-02-16

申请号：US11934381

申请日：2007-11-02

Applicant: Gregory Mathus ,  Terrence Kelly ,  Richard Cote

Inventor： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

IPC: B01L3/02

CPC classification number: B01L3/0217 ,  B01L3/0275 ,  B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2300/027 ,  Y10T137/0318 ,  Y10T436/2575

Abstract: The invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft includes a locking section located above a lower sealing section. The locking section has outwardly extending locking lobes circumferentially spaced around the mounting shaft and located above a stop member that separates the lower sealing section from the upper locking section. In certain embodiments, the diameter of the mounting shaft below the stop member is reduced in order to lessen insertion and ejection forces, which is particularly helpful for hand-held multi-channel pipettors. In these embodiments, the lower sealing section contains either a frustoconical sealing section, or an annular groove and a sealing ring, such as a flouroelastomeric O-ring seal.

Abstract translation: 本发明涉及移液器吸头安装轴构造和具有匹配构型的一次性吸头。 安装轴包括位于下密封部分上方的锁定部分。 锁定部分具有沿安装轴周向间隔开的向外延伸的锁定凸角，并且位于将下部密封部分与上部锁定部分分离的止挡部件上方。 在某些实施例中，降低止动件下方的安装轴的直径以减小插入和弹出力，这对手持式多通道移液器特别有帮助。 在这些实施例中，下密封部分包含截头圆锥形密封部分或环形凹槽和密封环，例如光滑弹性O形环密封件。

公开(公告)号：US08277757B2

公开(公告)日：2012-10-02

申请号：US12568801

申请日：2009-09-29

Applicant: Terrence Kelly ,  Richard Cote ,  Gregory Mathus

Inventor： Terrence Kelly ,  Richard Cote ,  Gregory Mathus

IPC: B01L3/00 ,  G01F19/00 ,  G01F25/00

CPC classification number: B01L3/0279 ,  B01L3/021 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2400/0487

Abstract: A pipette tip mounting shaft includes outwardly circumferentially extending locking lobes over which the pipette tip collar is mounted. The locking lobes preferably include an inclining ramp portion that gently flexes and distorts the pipette tip collar out-of-round as the mounting shaft is inserted into the pipette tip, rather than the stretching tip collar. Each locking lobe also includes a declining ramp portion which extends upward along the mounting shaft. The peak of the lobes is preferably curved. When the pipette tip is fully mounted on the mounting shaft, a locking ring on the inside surface of the tip collar engages the declining ramp of the lobes to provide an over-center engagement, however, the required ejection force is small.

Abstract translation: 移液管尖端安装轴包括向外周向延伸的锁定凸耳，移液管尖端套环安装在该凸起上。 锁定凸耳优选地包括倾斜斜面部分，当倾斜安装轴插入移液管尖端而不是拉伸尖端套环时，倾斜斜坡部分轻轻地弯曲和扭曲移液管尖端轴环。 每个锁定凸耳还包括沿安装轴向上延伸的下降斜面部分。 裂片的峰最好是弯曲的。 当移液管末端完全安装在安装轴上时，尖端套环的内表面上的锁定环接合凸角的下降斜面以提供过中心接合，然而，所需的弹出力很小。

公开(公告)号：US08033188B2

公开(公告)日：2011-10-11

申请号：US11856232

申请日：2007-09-17

Applicant: George Kalmakis ,  Gary Nelson ,  Gregory Mathus ,  Terrence Kelly ,  Joel Novak ,  Kenneth Steiner ,  Jonathan Finger

Inventor： George Kalmakis ,  Gary Nelson ,  Gregory Mathus ,  Terrence Kelly ,  Joel Novak ,  Kenneth Steiner ,  Jonathan Finger

IPC: G01N1/14 ,  B01L3/02 ,  G01F19/00

CPC classification number: B01L3/0217 ,  B01L3/0237 ,  B01L2200/0605 ,  B01L2200/087 ,  B01L2300/027 ,  B01L2400/0478 ,  G06F1/1626 ,  G06F1/1656 ,  G06F1/169

Abstract: A hand-held electronic pipettor includes menu driven software for controlling the information displayed on the user interface display, for inputting information to program the pipettor and for controlling the operation of the pipettor.

Abstract translation: 手持式电子移液器包括用于控制显示在用户界面显示上的信息的菜单驱动软件，用于输入信息以编程移液器并控制移液器的操作。

公开(公告)号：US20110005956A1

公开(公告)日：2011-01-13

申请号：US12885953

申请日：2010-09-20

Applicant: Gregory Mathus ,  Terrence Kelly

Inventor： Gregory Mathus ,  Terrence Kelly

IPC: B65D85/00 ,  G01F23/00

CPC classification number: B01L3/508 ,  B01L3/021 ,  B01L3/505 ,  B01L2300/028 ,  B01L2300/0854

Abstract: A liquid sample or liquid reagent reservoir kit employs a reusable reservoir base and disposable liners made of a clear transparent plastic material. Graduation marks are located on the sidewall surface of the basin in the reusable reservoir base, and are calibrated to measure liquid volumes in a disposable liner placed within the reusable reservoir base. The transparency of the clear disposable liner allows the liquid volume graduation marks on the sidewall of the basin in the reusable base to be observed through the disposable liner. The disposable liners are configured so that the liners can also be used as a cover. The geometry of the disposable liners facilitates tight nesting of stacked liners to facilitate shipping as well as storage on the laboratory bench top.

Abstract translation: 液体样品或液体试剂储存器套件采用可重复使用的储存器底座和由透明透明塑料材料制成的一次性衬垫。 刻度标记位于可重复使用的储存器底座中的盆的侧壁表面上，并且被校准以测量放置在可重复使用的储存器底座内的一次性衬垫中的液体体积。 透明一次性衬垫的透明度允许通过一次性衬垫观察可重复使用的底座中的盆的侧壁上的液体体积刻度。 一次性衬垫被构造成使得衬垫也可以用作罩。 一次性衬垫的几何形状有助于堆叠衬垫的紧密嵌套，以便于运输以及实验室台面上的储存。