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公开(公告)号：US20170305893A1
公开(公告)日：2017-10-26
申请号：US15517530
申请日：2015-10-08
发明人： Sabin LLONA-MINGUEZ , Andreas HOGLUND , Sylvain JACQUES , Lars JOHANSSON , Tobias KOOLMEISTER , Martin SCOBIE , Thomas HELLEDAY
IPC分类号： C07D417/10 , C07F5/02 , C07D405/04 , C07D403/10 , C07D401/10 , C07D235/12 , A61K31/4184 , C07D235/08 , A61K45/06 , A61K31/69 , A61K31/4439 , A61K31/427 , A61K31/4196 , C07D235/10 , C07F5/05
CPC分类号： C07D417/10 , A61K31/4184 , A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/69 , A61K45/06 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/12 , C07D401/10 , C07D403/10 , C07D405/04 , C07F5/025 , C07F5/05 , Y02A50/475
摘要： The invention relates to compounds of formula I, or a pharmaceutically-acceptable salt thereof. The present invention also relates to pharmaceutical formulations comprising these compounds, and to their use as medicaments for the treatment of disorders where modulation of DCTPP (deoxycytidine triphosphate pyrophosphatase 1) activity exerts a therapeutic effect.
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公开(公告)号：US20180170929A1
公开(公告)日：2018-06-21
申请号：US15899061
申请日：2018-02-19
发明人： Martin SCOBIE , THOMAS HELLEDAY , TOBIAS KOOLMEISTER , SYLVAIN JACQUES , MATTHIEU DESROSES , MARIE-CAROLINE JACQUES-CORDONNIER
IPC分类号： C07D471/04 , C07D417/12 , C07D405/14 , C07D453/02 , C07D403/14 , C07D401/14 , C07D409/04 , C07D403/12 , C07D405/04 , C07D401/04 , C07D403/04 , A61K31/5377 , A61K31/506 , C07D405/12 , A61K45/06 , A61K31/505 , C07D239/48 , C07B59/00
CPC分类号： C07D471/04 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/12 , C07D417/12 , C07D453/02 , C07D487/04 , A61K2300/00
摘要： A compound of formula I, or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.
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