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公开(公告)号：US20170196873A1
公开(公告)日：2017-07-13
申请号：US15315478
申请日：2015-06-04
发明人： Martin Scobie , Olov Wallner , Tobias Koolmeister , Karl Sven Axel Vallin , Carl Martin Henriksson , Evert Homan , Thomas Helleday , Sylvain Jacques , Matthieu Desroses , Marie-Caroline Jacques-Cordonnier , Roland Julius Yu Fiskesund
IPC分类号： A61K31/538 , A61K31/506 , A61K45/06 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/505 , A61K31/5377
CPC分类号： A61K31/538 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D239/48 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/04 , C07D491/048 , Y02A50/465 , A61K2300/00
摘要： A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.
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公开(公告)号：US20170197976A1
公开(公告)日：2017-07-13
申请号：US15315461
申请日：2015-06-04
发明人： Martin Scobie , Olov Wallner , Tobias Koolmeister , Karl Sven Axel Vallin , Carl Martin Henriksson , Sylvain Jacques , Evert Homan , Thomas Helleday
IPC分类号： C07D491/044 , A61K31/505 , A61K45/06 , C07D401/12 , A61K31/506 , C07D405/04 , C07D409/04 , C07D413/12 , A61K31/538 , C07D417/12 , C07D487/04 , C07D403/12 , C07D403/04 , A61K31/5377 , C07D401/04 , C07D413/14 , A61K31/53 , C07D405/12 , C07D239/48
CPC分类号： C07D491/044 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K31/538 , A61K45/06 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D473/16 , C07D473/34 , C07D487/04 , C07D491/048 , A61K2300/00
摘要： A compound of formula I, (I) or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer.
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公开(公告)号：US09944640B2
公开(公告)日：2018-04-17
申请号：US15447818
申请日：2017-03-02
发明人： Martin Scobie , Thomas Helleday , Tobias Koolmeister , Sylvain Jacques , Matthieu Desroses , Marie-Caroline Jacques-Cordonnier
IPC分类号： C07D471/04 , C07D417/12 , C07D401/04 , C07D239/48 , C07D405/12 , C07D405/14 , C07D405/04 , C07B59/00 , A61K31/505 , C07D403/12 , A61K31/506 , C07D403/14 , C07D409/04 , C07D403/04 , C07D453/02 , A61K45/06 , A61K31/5377 , C07D401/14
CPC分类号： C07D471/04 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/12 , C07D417/12 , C07D453/02 , C07D487/04 , A61K2300/00
摘要： A compound of formula I, or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.
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公开(公告)号：US20170305893A1
公开(公告)日：2017-10-26
申请号：US15517530
申请日：2015-10-08
发明人： Sabin LLONA-MINGUEZ , Andreas HOGLUND , Sylvain JACQUES , Lars JOHANSSON , Tobias KOOLMEISTER , Martin SCOBIE , Thomas HELLEDAY
IPC分类号： C07D417/10 , C07F5/02 , C07D405/04 , C07D403/10 , C07D401/10 , C07D235/12 , A61K31/4184 , C07D235/08 , A61K45/06 , A61K31/69 , A61K31/4439 , A61K31/427 , A61K31/4196 , C07D235/10 , C07F5/05
CPC分类号： C07D417/10 , A61K31/4184 , A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/69 , A61K45/06 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/12 , C07D401/10 , C07D403/10 , C07D405/04 , C07F5/025 , C07F5/05 , Y02A50/475
摘要： The invention relates to compounds of formula I, or a pharmaceutically-acceptable salt thereof. The present invention also relates to pharmaceutical formulations comprising these compounds, and to their use as medicaments for the treatment of disorders where modulation of DCTPP (deoxycytidine triphosphate pyrophosphatase 1) activity exerts a therapeutic effect.
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公开(公告)号：US09604937B2
公开(公告)日：2017-03-28
申请号：US14647400
申请日：2013-11-26
IPC分类号： C07D239/48 , C07D401/12 , C07D487/04 , C07D409/04 , C07D413/12 , C07D417/12 , C07D403/14 , A61K31/519 , A61K31/5377 , C07D403/12 , C07D405/14 , C07D401/14 , A61K45/06 , C07D471/04 , C07D405/12 , C07D405/04 , C07D401/04 , A61K31/506 , C07D403/04 , A61K31/505
CPC分类号： C07D471/04 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/12 , C07D417/12 , C07D453/02 , C07D487/04 , A61K2300/00
摘要： A compound of formula (I), or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.
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公开(公告)号：US10174029B2
公开(公告)日：2019-01-08
申请号：US15899061
申请日：2018-02-19
IPC分类号： C07D471/04 , C07D453/02 , C07B59/00 , C07D487/04 , A61K31/519 , C07D417/12 , C07D413/12 , C07D403/14 , C07D409/04 , C07D403/12 , C07D401/14 , A61K31/5377 , C07D401/12 , C07D405/14 , A61K45/06 , C07D401/04 , C07D405/12 , C07D239/48 , C07D405/04 , A61K31/506 , A61K31/505 , C07D403/04
摘要： A compound of formula I, or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.
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公开(公告)号：US10064869B2
公开(公告)日：2018-09-04
申请号：US15315478
申请日：2015-06-04
发明人： Martin Scobie , Olov Wallner , Tobias Koolmeister , Karl Sven Axel Vallin , Carl Martin Henriksson , Evert Homan , Thomas Helleday , Sylvain Jacques , Matthieu Desroses , Marie-Caroline Jacques-Cordonnier , Roland Julius Yu Fiskesund
IPC分类号： A61K31/538 , A61K31/506 , A61K45/06 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/505 , A61K31/5377
摘要： A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.
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公开(公告)号：US10179790B2
公开(公告)日：2019-01-15
申请号：US15315461
申请日：2015-06-04
发明人： Martin Scobie , Olov Wallner , Tobias Koolmeister , Karl Sven Axel Vallin , Carl Martin Henriksson , Sylvain Jacques , Evert Homan , Thomas Helleday
IPC分类号： A61K31/505 , C07D491/044 , A61K31/506 , C07D239/48 , C07D409/04 , C07D413/12 , C07D417/12 , A61K45/06 , A61K31/517 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K31/538 , C07D403/12 , C07D413/14 , C07D401/12 , C07D405/12 , C07D473/16 , C07D473/34 , C07D491/048 , C07D401/04 , C07D403/04 , C07D405/04 , C07D487/04
摘要： A compound of formula I, (I) or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer.
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公开(公告)号：US20180170929A1
公开(公告)日：2018-06-21
申请号：US15899061
申请日：2018-02-19
发明人： Martin SCOBIE , THOMAS HELLEDAY , TOBIAS KOOLMEISTER , SYLVAIN JACQUES , MATTHIEU DESROSES , MARIE-CAROLINE JACQUES-CORDONNIER
IPC分类号： C07D471/04 , C07D417/12 , C07D405/14 , C07D453/02 , C07D403/14 , C07D401/14 , C07D409/04 , C07D403/12 , C07D405/04 , C07D401/04 , C07D403/04 , A61K31/5377 , A61K31/506 , C07D405/12 , A61K45/06 , A61K31/505 , C07D239/48 , C07B59/00
CPC分类号： C07D471/04 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/12 , C07D417/12 , C07D453/02 , C07D487/04 , A61K2300/00
摘要： A compound of formula I, or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.
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公开(公告)号：US20170217961A1
公开(公告)日：2017-08-03
申请号：US15447818
申请日：2017-03-02
发明人： MARTIN SCOBIE , THOMAS HELLEDAY , TOBIAS KOOLMEISTER , SYLVAIN JACQUES , MATTHIEU DESROSES , MARIE-CAROLINE JACQUES-CORDONNIER
IPC分类号： C07D471/04 , A61K31/505 , A61K45/06 , C07D405/12 , A61K31/506 , A61K31/5377 , C07D403/04 , C07D401/04 , C07D405/04 , C07D403/12 , C07D409/04 , C07D401/14 , C07D403/14 , C07D453/02 , C07D405/14 , C07D417/12 , C07B59/00 , C07D239/48
CPC分类号： C07D471/04 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/12 , C07D417/12 , C07D453/02 , C07D487/04 , A61K2300/00
摘要： A compound of formula I, or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.
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