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公开(公告)号：US20180170929A1
公开(公告)日：2018-06-21
申请号：US15899061
申请日：2018-02-19
发明人： Martin SCOBIE , THOMAS HELLEDAY , TOBIAS KOOLMEISTER , SYLVAIN JACQUES , MATTHIEU DESROSES , MARIE-CAROLINE JACQUES-CORDONNIER
IPC分类号： C07D471/04 , C07D417/12 , C07D405/14 , C07D453/02 , C07D403/14 , C07D401/14 , C07D409/04 , C07D403/12 , C07D405/04 , C07D401/04 , C07D403/04 , A61K31/5377 , A61K31/506 , C07D405/12 , A61K45/06 , A61K31/505 , C07D239/48 , C07B59/00
CPC分类号： C07D471/04 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/12 , C07D417/12 , C07D453/02 , C07D487/04 , A61K2300/00
摘要： A compound of formula I, or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.
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公开(公告)号：US20170217961A1
公开(公告)日：2017-08-03
申请号：US15447818
申请日：2017-03-02
发明人： MARTIN SCOBIE , THOMAS HELLEDAY , TOBIAS KOOLMEISTER , SYLVAIN JACQUES , MATTHIEU DESROSES , MARIE-CAROLINE JACQUES-CORDONNIER
IPC分类号： C07D471/04 , A61K31/505 , A61K45/06 , C07D405/12 , A61K31/506 , A61K31/5377 , C07D403/04 , C07D401/04 , C07D405/04 , C07D403/12 , C07D409/04 , C07D401/14 , C07D403/14 , C07D453/02 , C07D405/14 , C07D417/12 , C07B59/00 , C07D239/48
CPC分类号： C07D471/04 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/12 , C07D417/12 , C07D453/02 , C07D487/04 , A61K2300/00
摘要： A compound of formula I, or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.
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