公开(公告)号：US20160138114A1

公开(公告)日：2016-05-19

申请号：US14899974

申请日：2014-06-18

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Dennis Slamon ,  Richard Finn ,  Dylan Conklin

IPC分类号： C12Q1/68 ,  G01N33/574 ,  A61K45/06 ,  A61K31/5025

CPC分类号： C12Q1/6886 ,  A61K31/5025 ,  A61K45/06 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57496 ,  G01N2333/914

摘要： Provided herein are methods of identifying a subject having a poly-ADP ribose polymerase (PARP) inhibitor-sensitive tumor by detecting a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a tumor sample from the subject. Also provided are methods of identifying a subject having a PARP inhibitor-sensitive tumor by detecting gene amplification of a CHD1L gene or an RTEL1 gene in a tumor sample from the subject. Further provided are methods of treating a tumor with a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a subject by administering an effective dose of a PARP inhibitor.

摘要翻译： 本文提供了通过检测来自受试者的肿瘤样品中的染色体1q21和/或染色体20q13.3中的基因组增益来鉴定具有多聚ADP核糖聚合酶（PARP）抑制剂敏感性肿瘤的受试者的方法。 还提供了通过检测来自受试者的肿瘤样品中CHD1L基因或RTEL1基因的基因扩增来鉴定具有PARP抑制剂敏感性肿瘤的受试者的方法。 还提供了通过施用有效剂量的PARP抑制剂来治疗受试者中染色体1q21和/或染色体20q13.3中的基因组增益的肿瘤的方法。

公开(公告)号：US20190292605A1

公开(公告)日：2019-09-26

申请号：US16369963

申请日：2019-03-29

申请人： The Regents of the University of California

发明人： Dennis Slamon ,  Richard Finn ,  Dylan Conklin ,  Erika von Euw

IPC分类号： C12Q1/6886 ,  A61K39/395 ,  A61K31/519 ,  C07K16/32 ,  A61K45/06

摘要： Provided herein are biomarkers indicating sensitivity or resistance to Cyclin D-CDK4/6 inhibitor therapy in cancer and methods of use.

公开(公告)号：US20170369950A1

公开(公告)日：2017-12-28

申请号：US15646074

申请日：2017-07-10

申请人： The Regents of the University of California

发明人： Dennis Slamon ,  Richard Finn ,  Dylan Conklin

IPC分类号： C12Q1/68 ,  G01N33/574 ,  A61K31/5025 ,  A61K45/06

CPC分类号： C12Q1/6886 ,  A61K31/5025 ,  A61K45/06 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57496 ,  G01N2333/914

摘要： Provided herein are methods of identifying a subject having a poly-ADP ribose polymerase (PARP) inhibitor-sensitive tumor by detecting a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a tumor sample from the subject. Also provided are methods of identifying a subject having a PARP inhibitor-sensitive tumor by detecting gene amplification of a CHD1L gene or an RTEL1 gene in a tumor sample from the subject. Further provided are methods of treating a tumor with a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a subject by administering an effective dose of a PARP inhibitor.

公开(公告)号：US20190048424A1

公开(公告)日：2019-02-14

申请号：US16107502

申请日：2018-08-21

申请人： The Regents of the University of California

发明人： Dennis Slamon ,  Richard Finn ,  Dylan Conklin

IPC分类号： C12Q1/6886 ,  G01N33/574 ,  A61K31/5025 ,  A61K45/06

摘要： Provided herein are methods of identifying a subject having a poly-ADP ribose polymerase (PARP) inhibitor-sensitive tumor by detecting a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a tumor sample from the subject. Also provided are methods of identifying a subject having a PARP inhibitor-sensitive tumor by detecting gene amplification of a CHDIL gene or an RTEL1 gene in a tumor sample from the subject. Further provided are methods of treating a tumor with a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a subject by administering an effective dose of a PARP inhibitor.

公开(公告)号：US20170067116A1

公开(公告)日：2017-03-09

申请号：US15123351

申请日：2015-03-04

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Dennis Slamon ,  Richard Finn ,  Dylan Conklin ,  Erika Von Euw

IPC分类号： C12Q1/68 ,  A61K31/519 ,  C07K16/32 ,  A61K45/06 ,  A61K39/395

CPC分类号： C12Q1/6886 ,  A61K31/519 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/32 ,  C07K2317/24 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158

摘要： Provided herein are biomarkers indicating sensitivity or resistance to Cyclin D-CDK4/6 inhibitor therapy in cancer and methods of use.

摘要翻译： 本文提供了表示对癌症中的细胞周期蛋白D-CDK4 / 6抑制剂治疗的敏感性或抗性及其使用方法的生物标志物。