公开(公告)号：US20230116602A1

公开(公告)日：2023-04-13

申请号：US17766147

申请日：2020-10-02

申请人： California Institute of Technology ,  1200 Pharma LLC ,  The Regents of the University of California

发明人： Brendan M. O' Boyle ,  Emma L. Baker-Tripp ,  Corey M. Reeves ,  Kevin C. Yang ,  Tristin E. Rose ,  Justin A. Hilf ,  Brian M. Stoltz ,  Michael D. Bartberger ,  Oliver C. Loson ,  Martina S. McDermott ,  Neil A. O'Brien ,  Dennis Slamon

IPC分类号： C07D513/04 ,  C07D417/14 ,  C07D471/04 ,  A61P35/00

摘要： The present disclosure provides compounds, such as compounds of Formula I, and compositions that are MCL1 inhibitors.

公开(公告)号：US20220372134A1

公开(公告)日：2022-11-24

申请号：US17719609

申请日：2022-04-13

申请人： The Regents of the University of California

发明人： Dylan CONKLIN ,  Dennis Slamon ,  Neil A. O'Brien ,  Michael J. Palazzolo ,  Erika Von Euw

IPC分类号： C07K16/28 ,  A61P35/00 ,  C12N15/63 ,  G01N33/574

摘要： The present disclosure provides antigen-binding proteins which bind to Claudin-6 (CLDN6). In various aspects, the antigen-binding proteins bind to Extracellular Loop 2 (EL2) of the extracellular domain of CLDN6. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.

公开(公告)号：US20190292605A1

公开(公告)日：2019-09-26

申请号：US16369963

申请日：2019-03-29

申请人： The Regents of the University of California

发明人： Dennis Slamon ,  Richard Finn ,  Dylan Conklin ,  Erika von Euw

IPC分类号： C12Q1/6886 ,  A61K39/395 ,  A61K31/519 ,  C07K16/32 ,  A61K45/06

摘要： Provided herein are biomarkers indicating sensitivity or resistance to Cyclin D-CDK4/6 inhibitor therapy in cancer and methods of use.

公开(公告)号：US20170369950A1

公开(公告)日：2017-12-28

申请号：US15646074

申请日：2017-07-10

申请人： The Regents of the University of California

发明人： Dennis Slamon ,  Richard Finn ,  Dylan Conklin

IPC分类号： C12Q1/68 ,  G01N33/574 ,  A61K31/5025 ,  A61K45/06

CPC分类号： C12Q1/6886 ,  A61K31/5025 ,  A61K45/06 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57496 ,  G01N2333/914

摘要： Provided herein are methods of identifying a subject having a poly-ADP ribose polymerase (PARP) inhibitor-sensitive tumor by detecting a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a tumor sample from the subject. Also provided are methods of identifying a subject having a PARP inhibitor-sensitive tumor by detecting gene amplification of a CHD1L gene or an RTEL1 gene in a tumor sample from the subject. Further provided are methods of treating a tumor with a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a subject by administering an effective dose of a PARP inhibitor.

公开(公告)号：US12065489B2

公开(公告)日：2024-08-20

申请号：US17846900

申请日：2022-06-22

申请人： The Regents of the University of California

发明人： Dylan Conklin ,  Martina S. McDermott ,  Neil A. O'Brien ,  Michael J. Palazzolo ,  Dennis Slamon ,  Erika Von Euw ,  Peter Bowers

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61K47/65 ,  A61K47/68 ,  A61P35/00 ,  G01N33/574

CPC分类号： C07K16/28 ,  A61K47/65 ,  A61K47/6817 ,  A61K47/6849 ,  A61P35/00 ,  G01N33/5748 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2319/00

摘要： The present disclosure provides antigen-binding proteins which bind to Claudin-6 (CLDN6). In various aspects, the antigen-binding proteins bind to Extracellular Loop 2 (EL2) of the extracellular domain of CLDN6. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.

公开(公告)号：US20230049752A1

公开(公告)日：2023-02-16

申请号：US17846900

申请日：2022-06-22

申请人： The Regents of the University of California

发明人： Dylan Conklin ,  Martina S. McDermott ,  Neil A. O'Brien ,  Michael J. Palazzolo ,  Dennis Slamon ,  Erika Von Euw ,  Peter Bowers

IPC分类号： C07K16/28 ,  A61K47/65 ,  A61K47/68 ,  A61P35/00 ,  G01N33/574

摘要： The present disclosure provides antigen-binding proteins which bind to Claudin-6 (CLDN6). In various aspects, the antigen-binding proteins bind to Extracellular Loop 2 (EL2) of the extracellular domain of CLDN6. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.

公开(公告)号：US20220177583A1

公开(公告)日：2022-06-09

申请号：US17441183

申请日：2020-03-20

申请人： The Regents of the University of California

发明人： Dylan Conklin ,  Martina S. McDermott ,  Neil A. O'Brien ,  Michael J. Palazzolo ,  Dennis Slamon ,  Erika Von Euw ,  Peter Bowers

IPC分类号： C07K16/28 ,  A61P35/00

摘要： The present disclosure provides bispecific antigen-binding proteins which bind to Claudin-6 (CLDN6) and a second antigen. In various aspects, the antigen-binding proteins bind to Extracellular Loop 2 (EL2) of the extracellular domain of CLDN6. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.

公开(公告)号：US20220162299A1

公开(公告)日：2022-05-26

申请号：US17441157

申请日：2020-03-20

申请人： The Regents of the University of California

发明人： Dylan Conklin ,  Martina S. McDermott ,  Neil A. O'Brien ,  Michael J. Palazzolo ,  Dennis Slamon ,  Erika Von Euw ,  Peter Bowers

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61K47/65 ,  A61P35/00 ,  G01N33/574

摘要： The present disclosure provides antigen-binding proteins which bind to Claudin-6 (CLDN6). In various aspects, the antigen-binding proteins bind to Extracellular Loop 2 (EL2) of the extracellular domain of CLDN6. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.

公开(公告)号：US20210355545A1

公开(公告)日：2021-11-18

申请号：US17284948

申请日：2019-10-15

申请人： The Johns Hopkins University ,  The Regents of the University of California

发明人： Victor E. Velculescu ,  Robert B. Scharpf ,  Eniko Papp ,  Dorothy Hallberg ,  Dennis Slamon ,  Gottfried Konecny

IPC分类号： C12Q1/6886

摘要： This document relates to methods and materials for assessing and/or treating mammals (e.g., humans) having cancer. For example, methods and materials for identifying a mammal as being likely to respond to a particular cancer treatment, and, optionally, for treating the mammal, are provided.

公开(公告)号：US11834499B1

公开(公告)日：2023-12-05

申请号：US17959104

申请日：2022-10-03

申请人： The Regents of the University of California

发明人： Dylan Conklin ,  Martina S. McDermott ,  Neil A. O'Brien ,  Michael J. Palazzolo ,  Dennis Slamon

IPC分类号： C07K16/28 ,  A61K47/68 ,  G01N33/68 ,  G01N33/574 ,  A61P1/18 ,  A61P35/00 ,  A61K39/00

CPC分类号： C07K16/28 ,  A61K47/6803 ,  A61K47/6849 ,  A61P1/18 ,  A61P35/00 ,  C07K16/2809 ,  G01N33/57492 ,  G01N33/68 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/77 ,  C07K2317/92

摘要： The present disclosure provides antigen-binding proteins which bind to Claudin-18.2 (CLDN18.2); bispecific antigen-binding proteins which bind to CLDN18.2 and a second antigen; and conjugates thereof. In various aspects, the antigen-binding proteins bind to Extracellular Loop 1 (EL1) of the extracellular domain of CLDN18.2. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.