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    SYNTHESIS OF NITRIC OXIDE GAS FOR INHALATION
    1.
    发明申请
    SYNTHESIS OF NITRIC OXIDE GAS FOR INHALATION 审中-公开
    用于吸入的氮氧化物气体的合成

    公开(公告)号：US20160030699A1

    公开(公告)日：2016-02-04

    申请号：US14777084

    申请日：2014-03-14

    申请人： THE GENERAL HOSPITAL CORPORATION

    发明人： Warren M. Zapol ,  Binglan Yu ,  Paul Hardin ,  Matthew Hickcox

    IPC分类号： A61M16/12 ,  A61M16/10 ,  A61M16/00

    摘要： In some additional aspects, an apparatus can include a chamber having an inlet valve for receiving a reactant gas and an outlet valve for delivering a product gas, a piston positioned inside the chamber and configured to move along a length of the chamber for adjusting pressure in the chamber, a sensor for collecting information related to one or more conditions of a respiratory system associated with a patient, a controller for determining one or more control parameters based on the collected information, and one or more pairs of electrodes positioned inside the chamber for initiating a series of electric arcs external to the patient to generate nitric oxide based on the determined control parameters.

    摘要翻译： 在一些另外的方面，设备可以包括具有用于接收反应物气体的入口阀和用于输送产物气体的出口阀的室，位于室内的活塞，并且构造成沿室的长度移动以调节压力 所述室，用于收集与患者相关联的呼吸系统的一个或多个条件相关的信息的传感器，用于基于所收集的信息确定一个或多个控制参数的控制器和位于所述腔室内的一对或多对电极， 基于所确定的控制参数，启动患者外部的一系列电弧以产生一氧化氮。

    Inspiratory synthesis of nitric oxide
    2.
    发明授权
    Inspiratory synthesis of nitric oxide 有权

    公开(公告)号：US10646682B2

    公开(公告)日：2020-05-12

    申请号：US16593718

    申请日：2019-10-04

    申请人： THE GENERAL HOSPITAL CORPORATION

    发明人： Warren M. Zapol ,  Binglan Yu ,  Paul Hardin ,  Matthew Hickcox

    IPC分类号： A61M16/12 ,  A61M16/10 ,  C01B21/20 ,  A61M15/02 ,  A61M16/00 ,  B01D53/56 ,  A61M16/04 ,  A61M16/06 ,  A61M16/20

    摘要： A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus including a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.

    INSPIRATORY SYNTHESIS OF NITRIC OXIDE
    3.
    发明申请
    INSPIRATORY SYNTHESIS OF NITRIC OXIDE 审中-公开

    公开(公告)号：US20190070383A1

    公开(公告)日：2019-03-07

    申请号：US16058797

    申请日：2018-08-08

    申请人： THE GENERAL HOSPITAL CORPORATION

    发明人： Warren M. Zapol ,  Binglan Yu ,  Paul Hardin ,  Matthew Hickcox

    IPC分类号： A61M16/12 ,  A61M16/00 ,  A61M16/10 ,  A61M16/20 ,  C01B21/20 ,  A61M16/06 ,  A61M15/02 ,  A61M16/04 ,  B01D53/56

    摘要： A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus in eluding a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.

    SYNTHESIS OF NITRIC OXIDE GAS FOR INHALATION
    6.
    发明申请
    SYNTHESIS OF NITRIC OXIDE GAS FOR INHALATION 审中-公开

    公开(公告)号：US20200345966A1

    公开(公告)日：2020-11-05

    申请号：US16933666

    申请日：2020-07-20

    申请人： The General Hospital Corporation

    发明人： Warren M. Zapol ,  Binglan Yu ,  Paul Hardin ,  Matthew Hickcox

    IPC分类号： A61M16/12 ,  A61M16/00 ,  A61M16/10 ,  C01B21/20 ,  A61M15/02 ,  B01D53/56 ,  A61M16/04 ,  A61M16/06 ,  A61M16/20

    摘要： In some additional aspects, an apparatus for generating nitric oxide (NO) can include one or more pairs of electrodes configured to initiate a series of electric arcs to synthesize a reactant gas into a product gas comprising NO, a sensor configured to measure a flow of a gas in a respiratory system into which the product gas is provided, a controller in communication with the one or more pairs of electrodes and the sensor. The controller is configured to adjust at least one of a pulse width, pulse period, pulse count per pulse group, pulse groups per second, energy generated by the one or more pairs of electrodes, arc frequency, arc current, and a voltage supplied to the one or more pairs of electrodes based on the measured flow to control a concentration of nitric oxide in the product gas.

    INSPIRATORY SYNTHESIS OF NITRIC OXIDE
    7.
    发明申请
    INSPIRATORY SYNTHESIS OF NITRIC OXIDE 审中-公开

    公开(公告)号：US20200345965A1

    公开(公告)日：2020-11-05

    申请号：US16833104

    申请日：2020-03-27

    申请人： THE GENERAL HOSPITAL CORPORATION

    发明人： Warren M. Zapol ,  Binglan Yu ,  Paul Hardin ,  Matthew Hickcox

    IPC分类号： A61M16/12 ,  A61M16/00 ,  A61M16/10 ,  C01B21/20 ,  A61M15/02 ,  B01D53/56 ,  A61M16/04 ,  A61M16/06 ,  A61M16/20

    摘要： A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus including a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.

    INSPIRATORY SYNTHESIS OF NITRIC OXIDE
    8.
    发明申请
    INSPIRATORY SYNTHESIS OF NITRIC OXIDE 审中-公开

    公开(公告)号：US20200030567A1

    公开(公告)日：2020-01-30

    申请号：US16593718

    申请日：2019-10-04

    申请人： THE GENERAL HOSPITAL CORPORATION

    发明人： Warren M. Zapol ,  Binglan Yu ,  Paul Hardin ,  Matthew Hickcox

    IPC分类号： A61M16/12 ,  A61M16/00 ,  A61M16/10 ,  C01B21/20 ,  A61M15/02 ,  B01D53/56 ,  A61M16/04 ,  A61M16/06 ,  A61M16/20

    摘要： A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus in-eluding a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.