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公开(公告)号：US11617764B2
公开(公告)日：2023-04-04
申请号：US16018582
申请日：2018-06-26
IPC分类号： A61K33/14 , A61K31/718 , A61M1/28 , A61J1/20 , A61J1/10
摘要： The present invention is a sterile peritoneal dialysis fluid, including an acidic first liquid containing 60.0 to 94.0 g/L of icodextrin and 0 to 2.34 g/L of sodium chloride, and an alkaline second liquid containing an alkaline pH regulator, in which the first liquid after sterilization has a pH of 5.0 to 5.5, the second liquid after sterilization has a pH of 6.5 to 7.5, and a mixture of the first liquid and the second liquid after sterilization has a pH of 6.0 to 7.5. The present invention can provide a peritoneal dialysis fluid containing icodextrin, in which the stability of icodextrin during the heat sterilization and the subsequent storage can be improved to the maximum, and the pH of the peritoneal dialysis fluid is close to the physiological range.
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公开(公告)号：US10010563B2
公开(公告)日：2018-07-03
申请号：US14435362
申请日：2012-11-27
CPC分类号： A61K33/14 , A61J1/10 , A61J1/202 , A61J1/2093 , A61K31/718 , A61M1/287 , A61K2300/00
摘要： The present invention is a sterile peritoneal dialysis fluid, including an acidic first liquid containing 60.0 to 94.0 g/L of icodextrin and 0 to 2.34 g/L of sodium chloride, and an alkaline second liquid containing an alkaline pH regulator, in which the first liquid after sterilization has a pH of 5.0 to 5.5, the second liquid after sterilization has a pH of 6.5 to 7.5, and a mixture of the first liquid and the second liquid after sterilization has a pH of 6.0 to 7.5. The present invention can provide a peritoneal dialysis fluid containing icodextrin, in which the stability of icodextrin during the heat sterilization and the subsequent storage can be improved to the maximum, and the pH of the peritoneal dialysis fluid is close to the physiological range.
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公开(公告)号：US20150250819A1
公开(公告)日：2015-09-10
申请号：US14435362
申请日：2012-11-27
IPC分类号： A61K33/14 , A61M1/28 , A61K31/718 , A61J1/10
CPC分类号： A61K33/14 , A61J1/10 , A61J1/202 , A61J1/2093 , A61K31/718 , A61M1/287 , A61K2300/00
摘要： The present invention is a sterile peritoneal dialysis fluid, including an acidic first liquid containing 60.0 to 94.0 g/L of icodextrin and 0 to 2.34 g/L of sodium chloride, and an alkaline second liquid containing an alkaline pH regulator, in which the first liquid after sterilization has a pH of 5.0 to 5.5, the second liquid after sterilization has a pH of 6.5 to 7.5, and a mixture of the first liquid and the second liquid after sterilization has a pH of 6.0 to 7.5. The present invention can provide a peritoneal dialysis fluid containing icodextrin, in which the stability of icodextrin during the heat sterilization and the subsequent storage can be improved to the maximum, and the pH of the peritoneal dialysis fluid is close to the physiological range.
摘要翻译： 本发明是一种无菌腹膜透析液，其包含含有60.0〜94.0g / L的高粘蛋白和0〜2.34g / L氯化钠的酸性第一液体，以及含有碱性pH调节剂的碱性第二液体，其中， 灭菌后的液体的pH为5.0〜5.5，杀菌后的第二液体的pH为6.5〜7.5，灭菌后的第一液体和第二液体的混合物的pH为6.0〜7.5。 本发明可以提供含有icodextrin的腹膜透析液，其中在加热灭菌和随后的储存期间，icodextrin的稳定性可以提高到最大，并且腹膜透析液的pH接近于生理范围。
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公开(公告)号：US20150231321A1
公开(公告)日：2015-08-20
申请号：US14435331
申请日：2012-11-27
IPC分类号： A61M1/28 , A61K31/718 , A61K33/14 , A61J1/10
CPC分类号： A61M1/287 , A61J1/10 , A61K31/718 , A61K33/00 , A61K33/14 , A61K47/02 , A61K47/12 , A61K47/36 , A61K2300/00
摘要： The present invention is a sterile peritoneal dialysis fluid, including an acidic first liquid containing only icodextrin and 0 to 2.34 g/L of sodium chloride, and an alkaline second liquid containing an alkaline pH regulator, in which the first liquid after sterilization has a pH of 5.0 to 5.5, the second liquid after sterilization has a pH of 6.5 to 7.5, and a mixture of the first liquid and the second liquid after sterilization has a pH of 6.0 to 7.5. The present invention can provide a peritoneal dialysis fluid containing icodextrin, in which the stability of icodextrin during the heat sterilization and the subsequent storage can be improved to the maximum, and the pH of the peritoneal dialysis fluid is close to the physiological range.
摘要翻译： 本发明是一种无菌腹膜透析液，其中含有仅含有icodextrin和0〜2.34g / L的氯化钠的酸性第一液体和含有碱性pH调节剂的碱性第二液体，其中灭菌后的第一液体具有pH 为5.0〜5.5，灭菌后的第二液体的pH为6.5〜7.5，灭菌后的第一液体和第二液体的混合物的pH为6.0〜7.5。 本发明可以提供含有icodextrin的腹膜透析液，其中在加热灭菌和随后的储存期间，icodextrin的稳定性可以提高到最大，并且腹膜透析液的pH接近于生理范围。
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公开(公告)号：US11020520B2
公开(公告)日：2021-06-01
申请号：US14435331
申请日：2012-11-27
IPC分类号： A61M1/28 , A61K31/718 , A61K33/14 , A61K33/00 , A61K47/12 , A61K47/36 , A61K47/02 , A61J1/10
摘要： The present invention is a sterile peritoneal dialysis fluid, including an acidic first liquid containing only icodextrin and 0 to 2.34 g/L of sodium chloride, and an alkaline second liquid containing an alkaline pH regulator, in which the first liquid after sterilization has a pH of 5.0 to 5.5, the second liquid after sterilization has a pH of 6.5 to 7.5, and a mixture of the first liquid and the second liquid after sterilization has a pH of 6.0 to 7.5. The present invention can provide a peritoneal dialysis fluid containing icodextrin, in which the stability of icodextrin during the heat sterilization and the subsequent storage can be improved to the maximum, and the pH of the peritoneal dialysis fluid is close to the physiological range.
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