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1.发明申请公开(公告)号：US20220310197A1
公开(公告)日：2022-09-29
申请号：US17615647
申请日：2020-06-04
Applicant: Tata Consultancy Services Limited
Inventor： Sharmila Shekhar MANDE , Swadha ANAND , Preethi Alagarai SAMPATH
Abstract: Co-infection of Pseudomonas aeruginosa and Staphylococcus aureus, exacerbates the virulence gene expression as well as shows higher antibacterial resistance than when they cause infections individually thereby making the infection extremely difficult to combat. A method and system for combating infections due to Pseudomonas aeruginosa and Staphylococcus aureus has been provided. The system provides strategies to combat pathogenic infections caused by multi-drug resistant (MDR) and extensively drug resistant (XDR) strains of Pseudomonas aeruginosa and Staphylococcus aureus. The strategy involves identifying potential target sites, which can be utilized to compromise its multiple virulence or essential functions at the same time. The idea utilizes the fact that a conserved stretch of nucleotide sequence occurring multiple times on a pathogen genome encoding virulence factors or in vicinity of genes essential for pathogen survival encoded within the genome of the candidate pathogen can be targeted to disrupt the overall genetic machinery of the pathogen.
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2.发明公开公开(公告)号：US20240355443A1
公开(公告)日：2024-10-24
申请号：US18602287
申请日：2024-03-12
Applicant: Tata Consultancy Services Limited
Inventor： Tungadri BOSE , Harrisham KAUR , Rashmi SINGH , Anirban DUTTA , Mohammed Monzoorul HAQUE , Sharmila Shekhar MANDE
Abstract: The present disclosure is related to a method and system for stratification of subjects as one of responders or non-responders to a therapy. It is imperative to critically evaluate the baseline/initial microbiome structure and composition of individuals and stratifying them before prescribing any microbiome-based drug/dietary interventions. The method identifies a panel of biological features/indicators/markers/signatures that can accurately stratify/classify/group individuals into responders and non-responders (for a given microbiome-based drug/therapy) based upon the differences in the metabolic functions of the gut microbial communities between the baseline gut microbiome profile (i.e. before the administration of an intervention) and after treatment gut microbiome profile (i.e. after the administration of the intervention). Individuals with samples showing an improvement in gut-health status after the administration of the pre-biotic intervention were tagged as responders and the rest were tagged as non-responders.
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公开(公告)号：US20190046105A1
公开(公告)日：2019-02-14
申请号：US16076622
申请日：2017-02-15
Applicant: Tata Consultancy Services Limited
Inventor： Sharmila Shekhar MANDE , Mohammed Monzoorul HAQUE , Anirban DUTTA , Nishal Kumar PINNA , Mitali MERCHANT
Abstract: System and method for assessing preterm delivery risk for pregnant subject is disclosed. Existing preterm delivery risk assessment methods provide results in late second or third trimester of pregnancy, so little time is available for medical advice. Presently disclosed method and system predict preterm delivery risk within 15 weeks of pregnancy. Microbiome characterization data obtained from microbiome sample from pregnant subject. ‘Microbial taxonomic abundance profile’ generated from microbiome characterization data, contains abundance values of microbes present in the microbiome sample. ‘Taxonomic Composition Skew’ value, and distribution characteristic value for ‘microbial taxonomic abundance profile’, quantifying biases in abundance values of microbes from the microbial taxonomic abundance profile, is computed. Risk of preterm delivery is determined based on the distribution characteristic value or ‘taxonomic composition skew’ value of the set DSR, wherein the set DSR comprises values quantifying biases in the abundance values of microbes from the microbiome sample.
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公开(公告)号：US20140244592A1
公开(公告)日：2014-08-28
申请号：US14157728
申请日：2014-01-17
Applicant: TATA CONSULTANCY SERVICES LIMITED
Inventor： Sharmila Shekhar MANDE , Anirban DUTTA , Tungadri BOSE , Mohammed Monzoorul HAQUE
IPC: G06F17/30
CPC classification number: G06F17/30073 , G06F17/30153 , H03M7/3059
Abstract: The present subject matter discloses a system and a method for data archival. A data archiving system comprises a processor and a compression module coupled to the processor and configured to compress an original data file to generate, for each level of lossy compression, a compressed base file and a patch file. The base file is generated using a lossy compression technique. The patch file for a particular level of lossy compression is generated using information lost at the particular level of lossy compression. The data archiving system further comprises a data archiving module coupled to the processor. The data archiving system is configured to save a last base file and a plurality of patch files corresponding to each level of lossy compression, where the last base file is the base file corresponding to a last level of lossy compression.
Abstract translation: 本主题公开了一种用于数据归档的系统和方法。 数据归档系统包括处理器和耦合到处理器的压缩模块，并且被配置为压缩原始数据文件，以针对每个有损压缩级别生成压缩的基本文件和补丁文件。 使用有损压缩技术生成基本文件。 使用在有损压缩的特定级别丢失的信息生成特定级别的有损压缩的补丁文件。 数据归档系统还包括耦合到处理器的数据归档模块。 数据归档系统被配置为保存最后的基本文件和对应于每个有损压缩级别的多个补丁文件，其中最后的基本文件是与最后一级有损压缩相对应的基本文件。
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5.发明公开公开(公告)号：US20240026468A1
公开(公告)日：2024-01-25
申请号：US18265479
申请日：2021-12-09
Applicant: Tata Consultancy Services Limited
Inventor： Anirban DUTTA , Nishal Kumar PINNA , Subhrajit BHAR , Tungadri BOSE , Sharmila Shekhar MANDE
IPC: C12Q1/689 , C12Q1/6869 , G16B10/00
CPC classification number: C12Q1/689 , C12Q1/6869 , G16B10/00
Abstract: This disclosure relates generally to the field of taxonomic profiling of microbial organisms such as bacteria, and, more particularly, to system and method for simultaneous interpretation of taxonomic distribution and replication rates of microbes constituting microbial communities. The present disclosure extracts bacterial genomic DNA from a plurality of bacterial organisms comprised in collected microbiome sample. Maps the plurality of the DNA sequence fragment reads to a precomputed reference sequence database of a plurality of all available completely sequenced bacterial genomes. Based on the mapping, the read coverage is measured at the genomic locations of the phylogenetic marker genes, wherein measured read coverage is used for interpretation of taxonomic distribution of the plurality of bacterial organisms. A plurality of slopes is obtained by fitting a linear function. The present disclosure interprets a replication rate for each of the plurality of bacterial organisms identified from the collected microbiome sample.
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Patent Agency Ranking
公开(公告)号：US20220310204A1
公开(公告)日：2022-09-29
申请号：US17615657
申请日：2020-06-05
Applicant: Tata Consultancy Services Limited
Inventor： Sharmila Shekhar MANDE , Swadha ANAND , Preethi Alagarai SAMPATH
Abstract: A system and method for identification of target sites in a pathogenic genome and combating a pathogenic infection have been provided. The present disclosure utilizes the fact that a conserved stretch of nucleotide sequence in genomic neighborhood of genes important for bacteria can be targeted to disrupt the overall functioning of the pathogen. The method involves identification of nucleotide repeat sequences in the DNA. The method and system also involve administration of a cocktail comprising antimicrobial drugs, biofilm inhibitors and a construct. The genomic neighborhood or vicinity or ‘flanking genes’ refers to regions lying within a predefined number of genes to the identified conserved stretch of nucleotide repeat sequence (or its reverse complement) on the candidate pathogen genome or within a distance of predefined number of bases with respect to the conserved stretch of nucleotide repeat sequence (or its reverse complement) on the candidate pathogen genome.
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公开(公告)号：US20220293277A1
公开(公告)日：2022-09-15
申请号：US17632800
申请日：2020-08-05
Applicant: Tata Consultancy Services Limited
Inventor： Sharmila Shekhar MANDE , Chandrani BOSE , Harrisham KAUR
Abstract: The onset of Parkinson's disease (PD) is a serious concern for elderly people and it is necessary to identify the risk for PD in an individual as early as possible. A system and method for risk assessment of an individual for Parkinson's disease (PD) has been provided. The system is using a non-invasive method for risk assessment of PD through prediction of metabolic potential of the bacteria residing in gastrointestinal tract of the individual. The system 100 is configured to calculate a score, which is evaluated from the gut bacterial taxonomic abundance profile, which is indicative of its metabolic potential for production of a particular neuroactive compound. This score is subsequently used to assess the risk of an individual of being affected by PD. Further, the present disclosure also provides microbiome based therapeutic approaches that can potentially minimize the side effects through maintaining the healthy cohort of bacteria in gut.
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8.发明申请公开(公告)号：US20170308645A1
公开(公告)日：2017-10-26
申请号：US15268245
申请日：2016-09-16
Applicant: Tata Consultancy Services Limited
Inventor： Sharmila Shekhar MANDE , Mohammed Monzoorul HAQUE , Tungadri BOSE , Anirban DUTTA , Venkata Siva Kumar Reddy CHENNAREDDY
Abstract: A method and system is provided for representing compositional properties of a biological sequence fragment and application thereof. The present application provides a method and system for representing compositional properties of a biological sequence fragment using a unidimensional compositional metric; comprising of collecting a plurality of biological sequence fragments; sequencing collected plurality of biological sequence fragments; generating a first set of reference vectors; computing a unidimensional compositional metric for each sequenced biological sequence fragment out of the plurality of sequenced biological sequence fragments as a cumulative function of the distance of the tetra-nucleotide frequency vector (v) from three or more reference vectors selected out of the generated first set of reference vectors; and segregating each sequenced biological sequence fragment out of the plurality of sequenced biological sequence fragments in to a plurality of groups based on respective unidimensional compositional metric.
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公开(公告)号：US20230154564A1
公开(公告)日：2023-05-18
申请号：US17985660
申请日：2022-11-11
Applicant: Tata Consultancy Services Limited
Inventor： Mohammed Monzoorul HAQUE , Sharmila Shekhar MANDE , Swadha ANAND
Abstract: This disclosure relates generally to methods and systems for designing a personalized composition that can counteract or reduce skin malodor. Conventional techniques that prepare compositions to treat specific malodorants are limited and such compositions cannot be personalized to an individual according to the type of malodorant produced on skin of the individual. The present disclosure provides a method for designing a personalized composition for degrading the malodorant present in skin of the subject. First, a biological sample from the subject is collected, and metabolite composition of the sample is determined. next, one or more malodorant in the sample are identified based on the metabolite composition. Further, a combination of bacteria capable of degrading the identified malodorant are identified using the microbe-malodorant microbial knowledge base and lastly the personalized composition of the identified bacteria is designed using the combination of bacteria.
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公开(公告)号：US20220328192A1
公开(公告)日：2022-10-13
申请号：US17634634
申请日：2020-08-12
Applicant: Tata Consultancy Services Limited
Inventor： Sharmila Shekhar MANDE , Tungadri BOSE , Subhrajit BHAR , Rashmi SINGH , Nishal Kumar PINNA
Abstract: Schizophrenia is a chronic and severe psychiatric disorder that affects how a person thinks, feels, and behaves. If Schizophrenia is diagnosed early, most symptoms of Schizophrenia can be managed with appropriate medical interventions. A system and method for assessing the risk of Schizophrenia in a person has been provided. The system is configured to assess individuals to check the presence or absence of Schizophrenia, by quantifying the abundance of sensory proteins in their microbiome. The disclosure relates to a defined methodology that involves assessment and categorization of the person into healthy and schizophrenic based on the abundance of sensory proteins in the microbiome. The systems and methods further describe microbiota based therapeutics for management of Schizophrenia through generating a therapeutic model and administering a consortium of healthy microbes which could modulate the disease microbiome composition towards a healthy equilibrium.
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