公开(公告)号：US20220328192A1

公开(公告)日：2022-10-13

申请号：US17634634

申请日：2020-08-12

Applicant: Tata Consultancy Services Limited

Inventor： Sharmila Shekhar MANDE ,  Tungadri BOSE ,  Subhrajit BHAR ,  Rashmi SINGH ,  Nishal Kumar PINNA

IPC: G16H50/30 ,  G16B25/10 ,  G16B30/10 ,  G16B40/20

Abstract: Schizophrenia is a chronic and severe psychiatric disorder that affects how a person thinks, feels, and behaves. If Schizophrenia is diagnosed early, most symptoms of Schizophrenia can be managed with appropriate medical interventions. A system and method for assessing the risk of Schizophrenia in a person has been provided. The system is configured to assess individuals to check the presence or absence of Schizophrenia, by quantifying the abundance of sensory proteins in their microbiome. The disclosure relates to a defined methodology that involves assessment and categorization of the person into healthy and schizophrenic based on the abundance of sensory proteins in the microbiome. The systems and methods further describe microbiota based therapeutics for management of Schizophrenia through generating a therapeutic model and administering a consortium of healthy microbes which could modulate the disease microbiome composition towards a healthy equilibrium.

公开(公告)号：US20240026468A1

公开(公告)日：2024-01-25

申请号：US18265479

申请日：2021-12-09

Applicant: Tata Consultancy Services Limited

Inventor： Anirban DUTTA ,  Nishal Kumar PINNA ,  Subhrajit BHAR ,  Tungadri BOSE ,  Sharmila Shekhar MANDE

IPC: C12Q1/689 ,  C12Q1/6869 ,  G16B10/00

CPC classification number: C12Q1/689 ,  C12Q1/6869 ,  G16B10/00

Abstract: This disclosure relates generally to the field of taxonomic profiling of microbial organisms such as bacteria, and, more particularly, to system and method for simultaneous interpretation of taxonomic distribution and replication rates of microbes constituting microbial communities. The present disclosure extracts bacterial genomic DNA from a plurality of bacterial organisms comprised in collected microbiome sample. Maps the plurality of the DNA sequence fragment reads to a precomputed reference sequence database of a plurality of all available completely sequenced bacterial genomes. Based on the mapping, the read coverage is measured at the genomic locations of the phylogenetic marker genes, wherein measured read coverage is used for interpretation of taxonomic distribution of the plurality of bacterial organisms. A plurality of slopes is obtained by fitting a linear function. The present disclosure interprets a replication rate for each of the plurality of bacterial organisms identified from the collected microbiome sample.