公开(公告)号：US20190010506A1

公开(公告)日：2019-01-10

申请号：US16069266

申请日：2016-12-28

Applicant: SYNLOGIC, INC.

Inventor： Dean Falb ,  Vincent M. Isabella ,  Jonathan W. Kotula ,  Paul F. Miller ,  Yves Millet ,  Adam B. Fisher ,  Sarah Elizabeth Rowe ,  Alex Tucker

IPC: C12N15/70 ,  A61K31/19 ,  C12N9/12 ,  C12N9/02 ,  A61K38/44 ,  A61K38/26 ,  A61K38/20 ,  A61K35/741 ,  A61K31/198 ,  A61K35/00

Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of attenuating metabolic diseases are disclosed.

公开(公告)号：US20180169154A1

公开(公告)日：2018-06-21

申请号：US15852762

申请日：2017-12-22

Applicant: Synlogic, Inc.

Inventor： Dean Falb ,  Paul F. Miller ,  Jonathan W. Kotula ,  Vincent M. Isabella ,  Suman Machinani ,  Adam B. Fisher ,  Yves Millet

IPC: A61K35/74 ,  C07K14/195 ,  A61K35/00

CPC classification number: A61K35/74 ,  A61K35/741 ,  A61K38/00 ,  A61K39/02 ,  A61K2035/11 ,  C07K14/195 ,  C07K14/245 ,  C12N9/0014 ,  C12N9/0022 ,  C12N9/88 ,  C12N15/70 ,  C12Y104/03002 ,  C12Y403/01024 ,  Y02A50/473

Abstract: Genetically programmed microorganisms, such as bacteria, pharmaceutical compositions thereof, and methods of modulating and treating a disease and/or disorder are disclosed.

公开(公告)号：US20170312320A1

公开(公告)日：2017-11-02

申请号：US15301324

申请日：2016-05-13

Applicant: Synlogic, Inc.

Inventor： Dean Falb ,  Vincent M. Isabella ,  Jonathan W. Kotula ,  Paul F. Miller ,  Sarah Rowe ,  Yves Millet

IPC: A61K35/741 ,  C07K14/245 ,  C12N15/70 ,  C12N9/88 ,  A61K35/00

CPC classification number: A61K35/74 ,  A61K35/741 ,  A61K38/00 ,  A61K39/02 ,  A61K2035/11 ,  C07K14/195 ,  C07K14/245 ,  C12N9/0014 ,  C12N9/0022 ,  C12N9/88 ,  C12N15/70 ,  C12Y104/03002 ,  C12Y403/01024

Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating diseases associated with hyperphenylalaninemia are disclosed.

公开(公告)号：US20170232043A1

公开(公告)日：2017-08-17

申请号：US15379445

申请日：2016-12-14

Applicant: Synlogic, Inc.

Inventor： Dean Falb ,  Paul F. Miller ,  Yves Millet ,  Vincent M. Isabella ,  Jonathan W. Kotula ,  Alex Tucker

IPC: A61K35/74 ,  A61K38/44 ,  C12N9/88 ,  C12N15/70 ,  C12N9/10 ,  C12N9/04 ,  C07K14/245 ,  A61K9/00 ,  C12N9/06

CPC classification number: A61K35/74 ,  A61K9/0019 ,  A61K9/0053 ,  A61K38/44 ,  A61K38/443 ,  C07K14/245 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/0016 ,  C12N9/0022 ,  C12N9/1096 ,  C12N9/88 ,  C12N15/52 ,  C12N15/70 ,  C12Y101/01 ,  C12Y101/01001 ,  C12Y101/01086 ,  C12Y104/01009 ,  C12Y104/03002 ,  C12Y206/01042 ,  C12Y401/01 ,  C12Y401/01001 ,  Y02A50/473

Abstract: The present disclosure provides recombinant bacterial cells that have been engineered with genetic circuitry which allow the recombinant bacterial cells to sense a patient's internal environment and respond by turning an engineered metabolic pathway on or off. When turned on, the recombinant bacterial cells complete all of the steps in a metabolic pathway to achieve a therapeutic effect in a host subject. These recombinant bacterial cells are designed to drive therapeutic effects throughout the body of a host from a point of origin of the microbiome. Specifically, the present disclosure provides recombinant bacterial cells comprising a heterologous gene encoding a branched chain amino acid catabolism enzyme. The disclosure further provides pharmaceutical compositions comprising the recombinant bacteria, and methods for treating disorders involving the catabolism of branched chain amino acids using the pharmaceutical compositions disclosed herein.

公开(公告)号：US20170136073A1

公开(公告)日：2017-05-18

申请号：US15319564

申请日：2016-05-13

Applicant: Synlogic, Inc.

Inventor： Dean Falb ,  Paul F. Miller ,  Jonathan W. Kotula ,  Vincent M. Isabella ,  Suman Machinani ,  Adam B. Fisher ,  Yves Millet

IPC: A61K35/74 ,  C07K14/195

CPC classification number: A61K35/74 ,  A61K35/741 ,  A61K38/00 ,  A61K39/02 ,  A61K2035/11 ,  C07K14/195 ,  C07K14/245 ,  C12N9/0014 ,  C12N9/0022 ,  C12N9/88 ,  C12N15/70 ,  C12Y104/03002 ,  C12Y403/01024 ,  Y02A50/473

Abstract: Genetically programmed microorganisms, such as bacteria, pharmaceutical compositions thereof, and methods of modulating and treating a disease and/or disorder are disclosed.

公开(公告)号：US20160340665A1

公开(公告)日：2016-11-24

申请号：US15154934

申请日：2016-05-13

Applicant: Synlogic, Inc.

Inventor： Dean Falb ,  Vincent M. Isabella ,  Jonathan W. Kotula ,  Paul F. Miller

IPC: C12N9/88 ,  C12N15/70 ,  A61K35/74 ,  C12N9/06

CPC classification number: A61K35/74 ,  A61K35/741 ,  A61K38/00 ,  A61K39/02 ,  A61K2035/11 ,  C07K14/195 ,  C07K14/245 ,  C12N9/0014 ,  C12N9/0022 ,  C12N9/88 ,  C12N15/70 ,  C12Y104/03002 ,  C12Y403/01024 ,  Y02A50/473

Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating diseases associated with hyperphenylalaninemia are disclosed.

Abstract translation: 公开了遗传工程细菌，其药物组合物，以及调节和治疗与高苯丙氨酸血症相关疾病的方法。

公开(公告)号：US20160206666A1

公开(公告)日：2016-07-21

申请号：US14998376

申请日：2015-12-22

Applicant: Synlogic, Inc.

Inventor： Dean Falb ,  Vincent M. Isabella ,  Jonathan W. Kotula ,  Paul F. Miller

IPC: A61K35/74 ,  C12N1/20 ,  C12N9/12 ,  C07K14/33 ,  C12N9/02 ,  A61K31/19 ,  C07K14/00

CPC classification number: C12N15/70 ,  A61K31/19 ,  A61K31/198 ,  A61K35/741 ,  A61K38/20 ,  A61K38/2013 ,  A61K38/2066 ,  A61K38/26 ,  A61K38/446 ,  A61K2035/115 ,  C12N9/001 ,  C12N9/1217 ,  C12Y103/08001 ,  C12Y115/01001 ,  C12Y207/02007 ,  Y02A50/401 ,  Y02A50/414 ,  Y02A50/473

Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.

Abstract translation: 公开了遗传工程细菌，其药物组合物，以及治疗或预防自身免疫疾病，抑制肠道炎症机制和/或收紧肠粘膜屏障功能的方法。

公开(公告)号：US20180280451A9

公开(公告)日：2018-10-04

申请号：US15852762

申请日：2017-12-22

Applicant: Synlogic, Inc.

Inventor： Dean Falb ,  Paul F. Miller ,  Jonathan W. Kotula ,  Vincent M. Isabella ,  Suman Machinani ,  Adam B. Fisher ,  Yves Millet

IPC: A61K35/74 ,  C07K14/195 ,  A61K35/00

Abstract: Genetically programmed microorganisms, such as bacteria, pharmaceutical compositions thereof, and methods of modulating and treating a disease and/or disorder are disclosed.

公开(公告)号：US20170253862A1

公开(公告)日：2017-09-07

申请号：US15599285

申请日：2017-05-18

Applicant: Synlogic, Inc.

Inventor： Dean Falb ,  Vincent M. Isabella ,  Jonathan W. Kotula ,  Paul F. Miller ,  Suman Machinani

IPC: C12N9/10 ,  C07K14/245 ,  A61K35/741 ,  A61K35/74 ,  C12R1/19

CPC classification number: C12N9/1029 ,  A61K35/74 ,  A61K35/741 ,  C07K14/245 ,  C12N15/52 ,  C12P7/52 ,  C12R1/19 ,  C12Y203/01001 ,  Y02A50/473

Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating disorders associated with hyperammonemia are disclosed.

公开(公告)号：US09688967B2

公开(公告)日：2017-06-27

申请号：US15164828

申请日：2016-05-25

Applicant: Synlogic, Inc.

Inventor： Dean Falb ,  Vincent M. Isabella ,  Jonathan W. Kotula ,  Paul F. Miller ,  Suman Machinani

IPC: A01N63/00 ,  C12N1/20 ,  C12N9/10 ,  A61K35/74 ,  C12R1/19 ,  A61K35/741 ,  C07K14/245 ,  C12N15/52 ,  C12N15/70 ,  C12P7/52

CPC classification number: C12N9/1029 ,  A61K35/74 ,  A61K35/741 ,  C07K14/245 ,  C12N15/52 ,  C12N15/70 ,  C12P7/52 ,  C12R1/19 ,  C12Y203/01001

Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating disorders associated with hyperammonemia are disclosed.