公开(公告)号：US20070110720A1

公开(公告)日：2007-05-17

申请号：US10579607

申请日：2004-11-17

Applicant: Susanne Brown ,  Joe Conner ,  Paul Dunn

Inventor： Susanne Brown ,  Joe Conner ,  Paul Dunn

IPC: A61K48/00 ,  C12N15/86 ,  C12N7/00

CPC classification number: C12N15/1135 ,  A01K2267/0331 ,  A61K35/13 ,  A61K48/00 ,  A61K2039/5256 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16643 ,  C12N2840/203

Abstract: A nucleic acid vector comprising first and second nucleotide sequences corresponding to nucleotide sequences flanking an insertion site in the genome of a selected herpes simplex virus strain; and a cassette located between said first and second nucleotide sequences comprising nucleic acid encoding: (a) one or a plurality of insertion sites and/or a nucleotide sequence of interest; and (b) a ribosome binding site or a regulatory nucleotide sequence; and (c) a marker is disclosed. Herpes simplex viruses generated using said vector, methods for their generation and herpes simplex viruses having a genome comprising heterologous nucleic acid are also disclosed.

Abstract translation: 核酸载体，其包含对应于选定的单纯疱疹病毒株的基因组中插入位点侧翼的核苷酸序列的第一和第二核苷酸序列; 和位于所述第一和第二核苷酸序列之间的盒，其包含编码以下核酸的核酸：（a）一个或多个插入位点和/或感兴趣的核苷酸序列; 和（b）核糖体结合位点或调节核苷酸序列; 和（c）公开了一种标记。 还公开了使用所述载体产生的单纯疱疹病毒，其产生的方法和具有包含异源核酸的基因组的单纯疱疹病毒。

公开(公告)号：US20070243167A1

公开(公告)日：2007-10-18

申请号：US11547951

申请日：2005-04-05

Applicant: Susanne Brown ,  Joe Conner

Inventor： Susanne Brown ,  Joe Conner

IPC: A61K48/00 ,  C12N7/00 ,  C12N15/86 ,  A61K38/28 ,  C07K14/62

CPC classification number: C12N15/86 ,  A61K48/00 ,  A61K48/0066 ,  A61K2039/5256 ,  C07K14/62 ,  C12N2710/16643 ,  C12N2830/00 ,  C12N2830/002 ,  C12N2830/85 ,  C12N2840/203

Abstract: An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding insulin is disclosed. Viruses disclosed are capable of expressing insulin. They may lack neurovirulence and may find use in the treatment of diseases involving abnormal insulin expression or function, such as diabetes.

Abstract translation: 公开了一种单纯疱疹病毒，其中单纯疱疹病毒基因组包含编码胰岛素的核酸。 所公开的病毒能够表达胰岛素。 它们可能缺乏神经毒力，可用于治疗涉及胰岛素异常或功能异常的疾病，如糖尿病。

公开(公告)号：US20050271620A1

公开(公告)日：2005-12-08

申请号：US10504460

申请日：2003-02-12

Applicant: Susanne Brown ,  Joe Conner

Inventor： Susanne Brown ,  Joe Conner

IPC: C12N15/09 ,  A61K35/76 ,  A61K47/48 ,  A61K48/00 ,  A61P35/00 ,  C07K14/005 ,  C07K14/82 ,  C07K16/00 ,  C07K19/00 ,  C12N7/00 ,  C12N15/86

CPC classification number: C07K14/005 ,  A61K48/00 ,  C12N2710/16622

Abstract: There is provided an HSV complex which comprises an avirulent HSV and a targeting agent which allows the HSV particle to infect and lyse a specific targeted cell. The inventors have found a way in which avirulent HSV can be targeted to disease cells, e.g. cancer cells, by incorporating an antibody binding domain into one or more viral glycoproteins.

Abstract translation: 提供了HSV复合物，其包含无毒性HSV和靶向剂，其允许HSV颗粒感染和裂解特异性靶向细胞。 本发明人已经找到了无毒性HSV可以靶向疾病细胞的方法，例如， 通过将抗体结合结构域掺入到一种或多种病毒糖蛋白中来形成癌细胞。

公开(公告)号：US20070292394A1

公开(公告)日：2007-12-20

申请号：US11765189

申请日：2007-06-19

Applicant: Susanne Brown ,  Alasdair Maclean ,  Nigel Fraser ,  Bruce Randazzo ,  Steven Albelda ,  Larry Kaiser ,  John Kucharczuk

Inventor： Susanne Brown ,  Alasdair Maclean ,  Nigel Fraser ,  Bruce Randazzo ,  Steven Albelda ,  Larry Kaiser ,  John Kucharczuk

IPC: A61K48/00 ,  A61P35/04

CPC classification number: C12N7/00 ,  A61K35/763 ,  C12N2710/16621 ,  C12N2710/16632

Abstract: A mutant herpes simplex virus which has been modified in the γ34.5 gene such that the gene is non-functional is used to treat a non-neuronal cancer such as a mesothelioma, ovarian carcinoma, bladder cancer or melanoma. Typically, the mutant herpes simplex virus has been modified within the BamHI restriction fragment of the long terminal repeat of the viral genome.

Abstract translation: 已经在γ34.5基因中被修饰以使得该基因是非功能性的突变单纯疱疹病毒被用于治疗非神经元癌，诸如间皮瘤，卵巢癌，膀胱癌或黑素瘤。 通常，突变单纯疱疹病毒已经在病毒基因组的长末端重复的BamHI限制性片段内被修饰。

公开(公告)号：US20050260169A1

公开(公告)日：2005-11-24

申请号：US11152591

申请日：2005-06-13

Applicant: Alasdair MacLean ,  Susanne Brown ,  Nigel Fraser ,  Bruce Randazzo

Inventor： Alasdair MacLean ,  Susanne Brown ,  Nigel Fraser ,  Bruce Randazzo

IPC: C12N15/09 ,  A61K35/76 ,  A61K35/763 ,  A61P35/00 ,  C12N7/00 ,  C12N15/00 ,  C12N15/38 ,  C12R1/92 ,  A61K48/00

CPC classification number: C12N7/00 ,  A61K35/763 ,  C12N2710/16621 ,  C12N2710/16632

Abstract: Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the γ34.5 gene in the long repeat region (RL) such that the γ34.5 gene is a non-functional, manufacture of medicaments and methods of testing cancer in mammals employing HSV mutant.

Abstract translation: 用作突变型单纯疱疹病毒的抗癌剂，其中突变病毒包含长重复区（R L L L）中的γ34.5基因的修饰，使得γ34.5基因是 非功能性制造药物和使用HSV突变体的哺乳动物测试癌症的方法。

公开(公告)号：US20070098689A1

公开(公告)日：2007-05-03

申请号：US10579606

申请日：2004-11-17

Applicant: Susanne Brown ,  Paul Dunn

Inventor： Susanne Brown ,  Paul Dunn

IPC: A61K48/00 ,  C12N15/86 ,  C12N7/00

CPC classification number: C12N15/1135 ,  A01K2267/0331 ,  A61K35/13 ,  A61K48/00 ,  A61K2039/5256 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16643 ,  C12N2840/203 ,  Y02A50/473

Abstract: An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a nitroreductase (NTR) is disclosed. Disclosed herpes simplex viruses are indicated to be useful in the treatment of cancer which may involve gene directed enzyme prodrug therapy.

Abstract translation: 公开了一种单纯疱疹病毒，其中单纯疱疹病毒基因组包含编码硝基还原酶（NTR）的核酸。 所公开的单纯疱疹病毒可用于治疗可能涉及基因定向酶前药治疗的癌症。

公开(公告)号：US20050226850A1

公开(公告)日：2005-10-13

申请号：US11148575

申请日：2005-06-08

Applicant: Susanne Brown ,  Alasdair MacLean ,  Nigel Fraser ,  Bruce Randazzo ,  Steven Albelda ,  Larry Kaiser ,  John Kucharczuk

Inventor： Susanne Brown ,  Alasdair MacLean ,  Nigel Fraser ,  Bruce Randazzo ,  Steven Albelda ,  Larry Kaiser ,  John Kucharczuk

IPC: A61K35/76 ,  A61K35/763 ,  A61K48/00

CPC classification number: C12N7/00 ,  A61K35/763 ,  C12N2710/16621 ,  C12N2710/16632

Abstract: A mutant herpes simplex virus which has been modified in the γ34.5 gene such that the gene is non-functional is used to treat a non-neuronal cancer such as a mesothelioma, ovarian carcinoma, bladder cancer or melanoma. Typically, the mutant herpes simplex virus has been modified within the BamHI restriction fragment of the long terminal repeat of the viral genome.

Abstract translation: 已经在γ34.5基因中被修饰以使得该基因是非功能性的突变单纯疱疹病毒被用于治疗非神经元癌，诸如间皮瘤，卵巢癌，膀胱癌或黑素瘤。 通常，突变单纯疱疹病毒已经在病毒基因组的长末端重复的BamHI限制性片段内被修饰。

公开(公告)号：US20070003520A1

公开(公告)日：2007-01-04

申请号：US10579622

申请日：2004-11-17

Applicant: Susanne Brown ,  Bhuvanesh Singh ,  Ian Ganly ,  Paul Dunn

Inventor： Susanne Brown ,  Bhuvanesh Singh ,  Ian Ganly ,  Paul Dunn

IPC: A61K48/00 ,  C12N7/00

CPC classification number: A61K38/00 ,  C12N15/1135 ,  C12N15/86 ,  C12N2710/16643 ,  C12N2840/203

Abstract: An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding an antisense to the squamous cell carcinoma related oncogene (asSCCRO); and an herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a short interfering ribonucleic acid (siRNA) molecule that is capable of repressing or silencing expression of squamous cell carcinoma related oncogene (SCCRO) nucleic acid or polypeptide are disclosed together with methods for generation and applications of such viruses.

Abstract translation: 单纯疱疹病毒，其中单纯疱疹病毒基因组包含编码与鳞状细胞癌相关致癌基因（asSCCRO）反义的核酸; 和单纯疱疹病毒，其中所述单纯疱疹病毒基因组包含编码能够抑制或沉默鳞状细胞癌相关致癌基因（SCCRO）核酸或多肽的表达的短干扰核糖核酸（siRNA）分子的核酸以及方法 用于生成和应用此类病毒。