公开(公告)号：US20090274728A1

公开(公告)日：2009-11-05

申请号：US12436382

申请日：2009-05-06

Applicant: Susanne Moira Brown ,  Bhuvanesh Singh ,  Ian Ganly ,  Paul Dunn

Inventor： Susanne Moira Brown ,  Bhuvanesh Singh ,  Ian Ganly ,  Paul Dunn

IPC: A61K39/245 ,  C12N7/01 ,  A61K35/76 ,  C12N15/66

CPC classification number: A61K38/00 ,  C12N15/1135 ,  C12N15/86 ,  C12N2710/16643 ,  C12N2840/203

Abstract: An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding an antisense to the squamous cell carcinoma related oncogene (asSCCRO); and an herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a short interfering ribonucleic acid (siRNA) molecule that is capable of repressing or silencing expression of squamous cell carcinoma related oncogene (SCCRO) nucleic acid or polypeptide are disclosed together with methods for generation and applications of such viruses.

Abstract translation: 单纯疱疹病毒，其中单纯疱疹病毒基因组包含编码与鳞状细胞癌相关致癌基因（asSCCRO）反义的核酸; 和单纯疱疹病毒，其中所述单纯疱疹病毒基因组包含编码能够抑制或沉默鳞状细胞癌相关致癌基因（SCCRO）核酸或多肽的表达的短干扰核糖核酸（siRNA）分子的核酸以及方法 用于生成和应用此类病毒。

公开(公告)号：US20070003520A1

公开(公告)日：2007-01-04

申请号：US10579622

申请日：2004-11-17

Applicant: Susanne Brown ,  Bhuvanesh Singh ,  Ian Ganly ,  Paul Dunn

Inventor： Susanne Brown ,  Bhuvanesh Singh ,  Ian Ganly ,  Paul Dunn

IPC: A61K48/00 ,  C12N7/00

CPC classification number: A61K38/00 ,  C12N15/1135 ,  C12N15/86 ,  C12N2710/16643 ,  C12N2840/203

Abstract: An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding an antisense to the squamous cell carcinoma related oncogene (asSCCRO); and an herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a short interfering ribonucleic acid (siRNA) molecule that is capable of repressing or silencing expression of squamous cell carcinoma related oncogene (SCCRO) nucleic acid or polypeptide are disclosed together with methods for generation and applications of such viruses.

Abstract translation: 单纯疱疹病毒，其中单纯疱疹病毒基因组包含编码与鳞状细胞癌相关致癌基因（asSCCRO）反义的核酸; 和单纯疱疹病毒，其中所述单纯疱疹病毒基因组包含编码能够抑制或沉默鳞状细胞癌相关致癌基因（SCCRO）核酸或多肽的表达的短干扰核糖核酸（siRNA）分子的核酸以及方法 用于生成和应用此类病毒。

公开(公告)号：US08530437B2

公开(公告)日：2013-09-10

申请号：US12436382

申请日：2009-05-06

Applicant: Susanne Moira Brown ,  Paul Dunn ,  Bhuvanesh Singh ,  Ian Ganly

Inventor： Susanne Moira Brown ,  Paul Dunn ,  Bhuvanesh Singh ,  Ian Ganly

IPC: C12N15/11 ,  A61K38/00 ,  C07H21/04 ,  C12Q1/68

CPC classification number: A61K38/00 ,  C12N15/1135 ,  C12N15/86 ,  C12N2710/16643 ,  C12N2840/203

Abstract: An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding an antisense to the squamous cell carcinoma related oncogene (asSCCRO); and an herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a short interfering ribonucleic acid (siRNA) molecule that is capable of repressing or silencing expression of squamous cell carcinoma related oncogene (SCCRO) nucleic acid or polypeptide are disclosed together with methods for generation and applications of such viruses.

Abstract translation: 单纯疱疹病毒，其中单纯疱疹病毒基因组包含编码与鳞状细胞癌相关致癌基因（asSCCRO）反义的核酸; 和单纯疱疹病毒，其中所述单纯疱疹病毒基因组包含编码能够抑制或沉默鳞状细胞癌相关致癌基因（SCCRO）核酸或多肽的表达的短干扰核糖核酸（siRNA）分子的核酸以及方法 用于生成和应用此类病毒。