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公开(公告)号：US20060219939A1
公开(公告)日：2006-10-05
申请号：US11292604
申请日：2005-12-02
CPC分类号： B03C5/005 , B03C5/024 , B03C5/026 , G01N21/6428 , G01N21/645 , G01N21/6458 , G01N2021/6482
摘要： A novel apparatus and method is described for detection of very small quantities (a few hundred molecules) of bioparticles in nanoliter/picoliter quantities of a sample. The apparatus involves a very small and low cost apparatus that contains a fluorometer. The detection process uses the fluorescence of nanoparticles. Dielectrophoresis is used to concentrate, mix and position the target particles with regard to the light sensor such that maximum detection efficiency is achieved. This allows low cost implementation of low cost point of care tests for disease (animal and plant), infection, food-borne bacteria detection, nucleotide sequencing and pathogen detection (bioterrorism) in real world applications.
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2.发明授权Method and apparatus for low quantity detection of bioparticles in small sample volumes 失效小样本体积中生物颗粒检测低量的方法和装置公开(公告)号：US07615762B2
公开(公告)日：2009-11-10
申请号：US11292604
申请日：2005-12-02
IPC分类号： G01N21/64
CPC分类号： B03C5/005 , B03C5/024 , B03C5/026 , G01N21/6428 , G01N21/645 , G01N21/6458 , G01N2021/6482
摘要： A novel apparatus and method is described for detection of very small quantities (a few hundred molecules) of bioparticles in nanoliter/picoliter quantities of a sample. The apparatus involves a very small and low cost apparatus that contains a fluorometer. The detection process uses the fluorescence of nanoparticles. Dielectrophoresis is used to concentrate, mix and position the target particles with regard to the light sensor such that maximum detection efficiency is achieved. This allows low cost implementation of low cost point of care tests for disease (animal and plant), infection, food-borne bacteria detection, nucleotide sequencing and pathogen detection (bioterrorism) in real world applications.
摘要翻译： 描述了一种新颖的装置和方法，用于在纳升/皮升量的样品中检测非常少量（几百分子）的生物颗粒。 该装置涉及包含荧光计的非常小且成本低的装置。 检测过程使用纳米颗粒的荧光。 介电电泳用于相对于光传感器浓缩，混合和定位目标颗粒，从而实现最大的检测效率。 这允许在现实世界应用中低成本实施疾病（动物和植物），感染，食源性细菌检测，核苷酸测序和病原体检测（生物恐怖主义）的低成本点护理测试。
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3.发明申请Method and detection and decontamination of antigens by nanoparticle-raman spectroscopy 审中-公开通过纳米粒子 - 拉曼光谱法对抗原的方法和检测和去污公开(公告)号：US20060275310A1
公开(公告)日：2006-12-07
申请号：US11222093
申请日：2005-09-08
申请人： Sulatha Dwarakanath , John Bruno
发明人： Sulatha Dwarakanath , John Bruno
IPC分类号： A61K39/40 , G01N33/554 , G01N33/569 , C07K16/12 , C07K16/46
CPC分类号： G01N33/56911 , G01N21/6428 , G01N21/65 , G01N33/54346 , G01N33/56983 , G01N2021/6417
摘要： A composition and method of detecting antigens and killing bacteria and virus is described. The composition and method comprise a fluorescent nanoparticle conjugated to a substance capable of binding specifically to a antigen and exposing the location containing the fluorescent nanoparticle and antigen to a wavelength of light capable of exciting the fluorescent nanoparticle.
摘要翻译： 描述了检测抗原并杀死细菌和病毒的组合物和方法。 组合物和方法包括与能够特异性结合抗原的物质缀合的荧光纳米颗粒，并将含有荧光纳米颗粒和抗原的位置暴露于能够激发荧光纳米颗粒的光的波长。
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公开(公告)号：US20090280472A1
公开(公告)日：2009-11-12
申请号：US11910598
申请日：2006-11-30
CPC分类号： G01N33/587 , G01N33/582
摘要： The field of the invention relates generally to the detection of antigens, including, but not limited to, quantum dots (Qdots) and metal oxide nanoparticles. More specifically, the invention relates to the detection of antigens on a surface or in a source, which antigens include bacteria, viruses, and small proteins. In some embodiments, the invention can be used to detect biological warfare agents, such as anthrax and ricin. In some embodiments, the invention can be used for early detection of diseases in human and animals. The invention may utilize a swab-test and may further utilize a filtration process, such as with a syringe-disc.
摘要翻译： 本发明的领域一般涉及抗原的检测，包括但不限于量子点（Q dot）和金属氧化物纳米颗粒。 更具体地，本发明涉及在表面或源上检测抗原，所述抗原包括细菌，病毒和小蛋白质。 在一些实施方案中，本发明可用于检测生物战剂，例如炭疽和蓖麻毒素。 在一些实施方案中，本发明可用于早期检测人和动物中的疾病。 本发明可以利用拭子检验，并且可以进一步利用过滤过程，例如用注射器盘。
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