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公开(公告)号:US20200207817A1
公开(公告)日:2020-07-02
申请号:US16633589
申请日:2018-07-25
申请人: Spiber Inc. , Riken
发明人: Keisuke Morita , Yunosuke Abe , Takehisa Maekawa , Koichi Kotaka , Junichi Sugahara , Keiji Numata
IPC分类号: C07K14/435 , D01F4/02 , C12N15/63
摘要: The present invention relates to a modified fibroin including a domain sequence represented by Formula 1: [(A)n motif-REP]m or Formula 2: [(A)n motif-REP]m-(A)n motif, in which the domain sequence has an amino acid sequence with a reduced content of a glutamine residue equivalent to an amino acid in which one or a plurality of glutamine residues in REP are deleted or substituted with other amino acid residues, as compared with a naturally occurring fibroin. [In Formula 1 and Formula 2, (A)n motif represents an amino acid sequence consisting of 4 to 27 amino acid residues, and the number of alanine residues with respect to the total number of amino acid residues in the (A)n motif is 80% or more. REP represents an amino acid sequence consisting of 10 to 200 amino acid residues. m represents an integer of 10 to 300. A plurality of (A)n motifs may be the same amino acid sequence or different amino acid sequences.]
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公开(公告)号:US20210340193A1
公开(公告)日:2021-11-04
申请号:US17280125
申请日:2019-09-30
申请人: Spiber Inc.
发明人: Tetsuo Asakura , Yunosuke Abe , Hideto Ishii
IPC分类号: C07K14/435 , D01F4/02
摘要: A production method of a protein composition, the method comprising a step of hydrolyzing an ester group by bringing a raw material composition containing an esterified protein into contact with an acidic or basic medium.
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公开(公告)号:US20210040648A1
公开(公告)日:2021-02-11
申请号:US16965626
申请日:2019-01-31
申请人: Spiber Inc.
发明人: Yunosuke Abe , Hirotada Ando
摘要: The present invention relates to a method for manufacturing a protein fiber, the method including a step of bringing a spinning raw liquid containing a spider silk protein and a solvent into contact with a coagulation liquid to coagulate the spider silk protein, in which the coagulation liquid contains a ketone.
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公开(公告)号:US20220074077A1
公开(公告)日:2022-03-10
申请号:US17279081
申请日:2019-09-27
申请人: Spiber Inc.
发明人: Yunosuke Abe , Masato Matsuo , Shota Togashi
摘要: The present invention provides a modified fibroin fiber having a shrinkage history of being irreversibly shrunk after spinning, the modified fibroin fiber containing modified fibroin, wherein a fiber diameter of a raw material fiber before being irreversibly shrunk exceeds 25 μm.
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公开(公告)号:US20210395317A1
公开(公告)日:2021-12-23
申请号:US17279564
申请日:2019-09-30
申请人: Spiber Inc.
发明人: Yunosuke Abe , Hirotada Ando , Koichi Kotaka
IPC分类号: C07K14/435 , C07K14/47 , D01D5/06 , D01F4/00 , D01F4/02
摘要: Disclosed is a method for producing a protein fiber, the method including: bringing a spinning dope containing a protein and an organic solvent into contact with a coagulation liquid to coagulate the protein, wherein a content of the protein in the spinning dope is more than 10% by mass based on a total amount of the spinning dope, and the coagulation liquid contains water or an aqueous solution of pH 0.25 or more and pH 10.00 or less.
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公开(公告)号:US20210095399A1
公开(公告)日:2021-04-01
申请号:US17043834
申请日:2019-04-03
申请人: Spiber Inc.
发明人: Yunosuke Abe , Shota Togashi
摘要: Provided is a side-by-side type composite fiber having a latent crimping ability, including a first component containing a modified fibroin and a second component containing a structural protein, in which the first component and the second component are joined to each other.
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公开(公告)号:US20220324923A1
公开(公告)日:2022-10-13
申请号:US17764669
申请日:2020-09-28
申请人: Spiber Inc.
发明人: Kentaro Takahashi , Atsushi Ikeda , Hideki Kagata , Yunosuke Abe , Kazuki Sakata
IPC分类号: C07K14/435 , D01F4/02
摘要: An object of the present invention is to provide a method for advantageously producing a protein molded article which can solve a problem caused by esterification of a hydroxyl group contained in a protein while maintaining a sufficient strength. A method for producing a protein molded article according to the present invention includes a step of bringing a raw material molded article containing a protein in which a hydroxyl group is esterified into contact with an acidic or basic medium in a state of applying a tensile force, thus hydrolyzing an ester group.
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公开(公告)号:US20220127755A1
公开(公告)日:2022-04-28
申请号:US17428136
申请日:2020-02-07
申请人: Spiber Inc.
发明人: Hirotada Ando , Hideto Ishii , Koichi Kotaka , Ryoko Sato , Hiroshi Kano , Jun Kobayashi , Akito Sato , Yunosuke Abe
IPC分类号: D01D5/06 , C07K14/435 , D01F4/02
摘要: An object of the present invention is to provide a method for producing an artificial structural protein fiber having a small diameter and having a stress equal to or higher than that of the related art. A method for producing an artificial structural protein fiber according to the present invention is a method for producing an artificial structural protein fiber by a wet spinning method, the method including a coagulation step of discharging a spinning dope containing an artificial structural protein and an organic solvent from a spinneret into a coagulation liquid to coagulate the artificial structural protein, wherein a bath draft in the coagulation step is more than 0.4 and 20 or less.
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9.
公开(公告)号:US20200165311A1
公开(公告)日:2020-05-28
申请号:US16611315
申请日:2018-05-09
发明人: Ayumi Abe , Keisuke Morita , Kenji Kurachi , Yunosuke Abe
摘要: The present invention relates to a polypeptide solution in which polypeptide including an amino acid sequence derived from type I keratin that belongs to Cluster Ia is dissolved in a solvent including a formic acid or a solvent including an aprotic polar agent having a dipole moment of 3.0 D or more and an inorganic salt.
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公开(公告)号:US20230039765A1
公开(公告)日:2023-02-09
申请号:US17762912
申请日:2020-09-25
申请人: Spiber Inc.
发明人: Hideto Ishii , Mizuki Igarashi , Tatsuki Adachi , Yunosuke Abe
IPC分类号: C07K14/435 , D02J1/22 , D01F4/02 , D01D5/06
摘要: An object of the present invention is to provide a method capable of producing a protein fiber in which shrinkage at the time of first contact with moisture after production is more reliably suppressed and generation of crimp is also suppressed. A method for producing a protein fiber according to the present invention includes: a pre-shrinking step of shrinking a protein fibril in a relaxed state after drawing and before being wound; a winding step of winding the protein fibril subjected to the pre-shrinking step to obtain a wound product; and a post-shrinking step of shrinking the protein fibril subjected to the winding step in a relaxed state.
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