公开(公告)号：US12048722B2

公开(公告)日：2024-07-30

申请号：US17816371

申请日：2022-07-29

申请人： Solarea Bio, Inc.

发明人： Gerardo V. Toledo ,  Maria Juliana Soto-Giron ,  Jinwoo Kim ,  Julie E. Button ,  Eric Michael Schott

IPC分类号： A61K35/741 ,  A23L33/125 ,  A23L33/135 ,  A23L33/14 ,  A61K31/702 ,  A61K35/744 ,  A61K36/062 ,  A61K45/06 ,  A61P19/08 ,  A61P19/10

CPC分类号： A61K35/741 ,  A23L33/125 ,  A23L33/135 ,  A23L33/14 ,  A61K31/702 ,  A61K35/744 ,  A61K36/062 ,  A61K45/06 ,  A61P19/08 ,  A61P19/10 ,  A23V2002/00 ,  A23V2400/173 ,  A23V2400/321 ,  A23V2400/427

摘要： Described herein are methods and compositions for using microbial agents (probiotics) and agents that promote growth of certain microbes (prebiotics) for management (including prevention and treatment) of musculoskeletal disorders, including osteoporosis, osteopenia, Paget's disease, stunting, osteoarthritis, osteomyelitis, and delayed or non-union fractures.

公开(公告)号：US20230256035A1

公开(公告)日：2023-08-17

申请号：US18304264

申请日：2023-04-20

申请人： Solarea Bio, Inc.

发明人： Eric Michael Schott ,  Gerardo V. Toledo ,  Maria Juliana Soto-Giron ,  Alicia Eve Ballok ,  Ryan Green ,  Mark Charbonneau

IPC分类号： A61K35/742 ,  A23L33/135 ,  A23L33/15 ,  A23L33/105 ,  A61K31/525 ,  A61P29/00

CPC分类号： A61K35/742 ,  A23L33/135 ,  A23L33/15 ,  A23L33/105 ,  A61K31/525 ,  A61P29/00

摘要： This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

公开(公告)号：US20240226201A9

公开(公告)日：2024-07-11

申请号：US18477298

申请日：2023-09-28

申请人： Solarea Bio, Inc.

发明人： Eric Michael Schott ,  Gerardo V. Toledo ,  Maria Juliana Soto-Giron ,  Alicia Eve Ballok ,  Ryan Green ,  Mark Charbonneau

IPC分类号： A61K35/747 ,  A23L33/105 ,  A23L33/135 ,  A23L33/15 ,  A61K31/525 ,  A61K35/742 ,  A61K45/06 ,  A61P29/00

CPC分类号： A61K35/747 ,  A23L33/105 ,  A23L33/135 ,  A23L33/15 ,  A61K31/525 ,  A61K35/742 ,  A61K45/06 ,  A61P29/00

摘要： This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

公开(公告)号：US10596209B2

公开(公告)日：2020-03-24

申请号：US16235858

申请日：2018-12-28

申请人： Solarea Bio, Inc.

发明人： Gerardo V. Toledo ,  Tracy Mincer ,  Jahir Mauricio Gutierrez Bugarin ,  Jillian DeWalt ,  Eric Schott ,  Maria Juliana Soto Giron

IPC分类号： A61K35/747 ,  A61P3/10 ,  A23L29/00 ,  A61P3/04 ,  A61K35/74 ,  A61K35/741 ,  A61K45/06

摘要： The present invention relates to the identification of a group of microorganisms, which are relatively abundant in the microbial communities associated with fruits and vegetables typically consumed raw and therefore transient or permanent members of the human microbiota. The consumption of mixtures of these microbes at relevant doses will produce a beneficial effect in the host by reducing the propensity to diabetes, obesity and metabolic syndrome mediated in part by production of short chain fatty acids to enhance colonic butyrate production. Therapeutic methods of the invention involve the use of live microorganisms or metabolites derived from said microorganisms to establish a microbial composition in the mammalian host that will improve significantly the ability to control weight, reduce the onset of diabetes, obesity and metabolic syndrome, and improve overall health.

公开(公告)号：US11980647B2

公开(公告)日：2024-05-14

申请号：US18053262

申请日：2022-11-07

申请人： Solarea Bio, Inc.

发明人： Eric Michael Schott ,  Gerardo V. Toledo ,  Maria Juliana Soto-Giron

IPC分类号： A61K35/741 ,  A23L33/00 ,  A23L33/105 ,  A23L33/125 ,  A23L33/135 ,  A61K9/00 ,  A61K31/702 ,  A61K35/747 ,  A61K36/062 ,  A61K36/45 ,  A61K47/12 ,  A61P15/12 ,  A61P19/10 ,  A61K35/00

CPC分类号： A61K35/747 ,  A23L33/105 ,  A23L33/125 ,  A23L33/135 ,  A23L33/40 ,  A61K9/0053 ,  A61K31/702 ,  A61K36/062 ,  A61K36/45 ,  A61K47/12 ,  A61P15/12 ,  A61P19/10 ,  A23V2400/121 ,  A23V2400/169 ,  A23V2400/321 ,  A61K2035/115

摘要： Described herein are methods and compositions for using microbial agents (probiotics) and agents that promote growth of certain microbes (prebiotics) for management (including prevention and treatment) of musculoskeletal disorders, including osteoporosis, osteopenia, Paget's disease, stunting, osteoarthritis, osteomyelitis, and delayed or non-union fractures. Also described herein are methods and compositions for using probiotics and prebiotics for management of inflammation, and symptoms of menopause.

公开(公告)号：US20240131091A1

公开(公告)日：2024-04-25

申请号：US18477298

申请日：2023-09-27

申请人： Solarea Bio, Inc.

发明人： Eric Michael Schott ,  Gerardo V. Toledo ,  Maria Juliana Soto-Giron ,  Alicia Eve Ballok ,  Ryan Green ,  Mark Charbonneau

IPC分类号： A61K35/747 ,  A23L33/105 ,  A23L33/135 ,  A23L33/15 ,  A61K31/525 ,  A61K35/742 ,  A61K45/06 ,  A61P29/00

CPC分类号： A61K35/747 ,  A23L33/105 ,  A23L33/135 ,  A23L33/15 ,  A61K31/525 ,  A61K35/742 ,  A61K45/06 ,  A61P29/00

摘要： This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

公开(公告)号：US11819524B2

公开(公告)日：2023-11-21

申请号：US16694876

申请日：2019-11-25

申请人： Solarea Bio, Inc.

发明人： Gerardo V. Toledo ,  Eric Michael Schott ,  Maria Juliana Soto-Giron ,  Jinwoo Kim ,  Julie E. Button

IPC分类号： A61K35/741 ,  A23L33/14 ,  A23L33/125 ,  A23L33/135 ,  A61P19/08 ,  A61P19/10 ,  A61K31/702 ,  A61K35/744 ,  A61K36/062

CPC分类号： A61K35/741 ,  A23L33/125 ,  A23L33/135 ,  A23L33/14 ,  A61K31/702 ,  A61K35/744 ,  A61K36/062 ,  A61P19/08 ,  A61P19/10 ,  A23V2002/00 ,  A23Y2220/71 ,  A23Y2260/35 ,  A23Y2280/55

摘要： Described herein are methods and compositions for using microbial agents (probiotics) and agents that promote growth of certain microbes (prebiotics) for management (including prevention and treatment) of musculoskeletal disorders, including osteoporosis, osteopenia, Paget's disease, stunting, osteoarthritis, osteomyelitis, and delayed or non-union fractures.

公开(公告)号：US20200164002A1

公开(公告)日：2020-05-28

申请号：US16694876

申请日：2019-11-25

申请人： Solarea Bio, Inc.

发明人： Gerardo V. Toledo ,  Eric Michael Schott ,  Maria Juliana Soto-Giron ,  Jinwoo Kim ,  Julie E. Button

IPC分类号： A61K35/741 ,  A61K31/702 ,  A61P19/08 ,  A61P19/10 ,  A61K35/744 ,  A61K36/062 ,  A23L33/135 ,  A23L33/14 ,  A23L33/125

摘要： Described herein are methods and compositions for using microbial agents (probiotics) and agents that promote growth of certain microbes (prebiotics) for management (including prevention and treatment) of musculoskeletal disorders, including osteoporosis, osteopenia, Paget's disease, stunting, osteoarthritis, osteomyelitis, and delayed or non-union fractures.

公开(公告)号：US11938158B2

公开(公告)日：2024-03-26

申请号：US18181495

申请日：2023-03-09

申请人： Solarea Bio, Inc.

发明人： Eric Michael Schott ,  Maria Juliana Soto-Giron ,  Gerardo V. Toledo

IPC分类号： A61K35/741 ,  A61K9/00 ,  A61K31/122 ,  A61K31/355 ,  A61K31/375 ,  A61K31/593 ,  A61K35/744 ,  A61K35/747 ,  A61K36/064 ,  A61K47/26 ,  A61K47/46 ,  A61P15/12

CPC分类号： A61K35/747 ,  A61K9/0056 ,  A61K31/122 ,  A61K31/355 ,  A61K31/375 ,  A61K31/593 ,  A61K35/744 ,  A61K36/064 ,  A61K47/26 ,  A61K47/46 ,  A61P15/12

摘要： Described herein are methods and compositions for using microbial agents (probiotics) and agents that promote growth of certain microbes (prebiotics) for management (including prevention and treatment) of musculoskeletal disorders, including osteoporosis, osteopenia, Paget's disease, stunting, osteoarthritis, osteomyelitis, and delayed or non-union fractures. Also described herein are methods and compositions for using probiotics and prebiotics for management of inflammation, and symptoms of menopause.

公开(公告)号：US20230309598A1

公开(公告)日：2023-10-05

申请号：US18067470

申请日：2022-12-16

申请人： Solarea Bio, Inc.

发明人： Alicia Eve Ballok ,  Josephine James Kennedy ,  Gerardo V. Toledo ,  Eric Michael Schott ,  Tracy Mincer

IPC分类号： A23L33/135

CPC分类号： A23L33/135

摘要： The present invention relates to the identification of a group of microorganisms, which are relatively abundant in the microbial communities associated with fruits and vegetables typically consumed raw and therefore transient or permanent members of the human microbiota. The consumption of mixtures of these microbes at relevant doses will produce a beneficial health effect in the host. The present invention relates to methods of using these microbes to increase the presence of beneficial microbes in crops eaten raw.