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1.发明申请Wound dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan and incorporating silver nanoparticles 审中-公开伤口敷料组件，系统和方法由亲水聚合物海绵结构如壳聚糖和纳米银纳米粒子形成公开(公告)号：US20090130186A1
公开(公告)日：2009-05-21
申请号：US12313530
申请日：2008-10-21
申请人： Simon J. McCarthy , Jess Kimball
发明人： Simon J. McCarthy , Jess Kimball
CPC分类号： A61F13/00995 , A61F2013/00157 , A61F2013/00463 , A61F2013/00519 , A61F2013/0054 , A61F2013/00931 , A61F2013/00936 , A61L15/18 , A61L15/28 , A61L15/425 , A61L2400/12 , C08L5/08
摘要： Silver nanoparticles are mixed with a chitosan solution, to form a chitosan/silver nanoparticle dispersion, which is then subjected to a freeze-drying process, to form a chitosan/silver nanoparticle matrix suitable for use as a wound dressing.
摘要翻译： 将银纳米颗粒与壳聚糖溶液混合以形成壳聚糖/银纳米颗粒分散体，然后将其进行冷冻干燥过程，以形成适合用作伤口敷料的壳聚糖/银纳米颗粒基质。
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2.发明申请Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma 审中-公开用于制备，储存和施用冷冻干燥物质如冷冻干燥等离子体的装置和方法公开(公告)号：US20090223080A1
公开(公告)日：2009-09-10
申请号：US12378470
申请日：2009-02-13
申请人： Simon J. McCarthy , Lisa A. Buckley
发明人： Simon J. McCarthy , Lisa A. Buckley
IPC分类号： F26B5/06
CPC分类号： A61J1/2093 , A61B50/10 , A61B50/13 , A61B50/30 , A61B90/96 , A61J1/10 , A61J1/1475 , A61J1/201 , A61J1/2013 , A61J1/2027 , A61J1/2037 , A61M2039/1061
摘要： A method for preparing and a system containing freeze-dried plasma that will be reconstituted. Ascorbic acid is incorporated into the freeze-dried plasma prior to the plasma being reconstituted.
摘要翻译： 一种制备方法和含有将被重构的冷冻干燥等离子体的体系。 在等离子体重构之前，将抗坏血酸并入冷冻干燥的血浆中。
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3.发明申请Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma 审中-公开用于制备，储存和施用冷冻干燥物质如冷冻干燥等离子体的装置和方法公开(公告)号：US20090107001A1
公开(公告)日：2009-04-30
申请号：US12283885
申请日：2008-09-16
申请人： Simon J. McCarthy
发明人： Simon J. McCarthy
IPC分类号： F26B5/06
CPC分类号： F26B5/06 , A61B50/10 , A61B50/13 , A61B50/30 , A61B90/96 , A61J1/10 , A61J1/1475 , A61J1/201 , A61J1/2013 , A61J1/2027 , A61J1/2037 , A61J1/2093 , A61M2039/1061
摘要： Single unit human plasma is dispensed from a source transfer bag into a receptacle in which the plasma under goes freeze-drying. During the dispensing of the plasma from the source transfer container into the freeze-drying receptacle, an inline treatment device treats the plasma prior to freeze-drying, e.g., by the removal of cellular blood components, or by the removal of pathogens or viral or bacterial agents, or by the removal or neutralization of blood group specific antibodies.
摘要翻译： 将单体人血浆从源转移袋分配到容器中，等离子体在其中进行冷冻干燥。 在将等离子体从源转移容器分配到冷冻干燥容器期间，在线处理装置在冷冻干燥之前处理血浆，例如通过去除细胞血液成分，或通过去除病原体或病毒或 细菌剂，或通过去除或中和血型特异性抗体。
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4.发明申请Wound dressing and method for controlling severe, life-threatening bleeding 审中-公开伤口敷料和控制严重威胁生命的出血的方法公开(公告)号：US20080213344A1
公开(公告)日：2008-09-04
申请号：US12148320
申请日：2008-04-18
IPC分类号： A61K31/715 , A61L15/00
CPC分类号： A61F13/0203 , A61F5/40 , A61F13/00063 , A61F13/0253 , A61F13/0256 , A61F13/0276 , A61F13/0289 , A61F13/36 , A61F17/00 , A61F2013/00106 , A61F2013/00221 , A61F2013/00463 , A61F2013/00468 , A61F2013/00472 , A61F2013/0054 , A61F2013/00659 , A61F2013/00676 , A61F2013/0071 , A61F2013/00719 , A61F2013/00931 , A61L15/28 , A61L15/425 , A61L2400/04 , C08L1/00 , C08L5/08
摘要： This invention is directed to advanced hemorrhage control wound dressings, and methods of using and producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe 5 bleeding. The wound dressing for controlling severe bleeding is formed of a biomaterial comprising chitosan, a hydrophilic polymer, a polyacrylic polymer or a combination thereof, The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional 10 pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot formation at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of 15 blood out of the wound site.
摘要翻译： 本发明涉及先进的出血控制伤口敷料，以及其使用和生产方法。 受试者伤口敷料由非哺乳动物材料构成以控制严重的5次出血。 用于控制严重出血的伤口敷料由包含壳聚糖，亲水性聚合物，聚丙烯酸聚合物或其组合的生物材料形成。本发明预期的严重的威胁生命的出血通常是不能被固定的类型 当常规的纱布伤口敷料以常规10压力施加到受试者伤口时。 伤口敷料能够通过粘附到伤口部位上来严重地伤害来自创伤的危及生命的出血的流动，以密封伤口，以加速伤口部位的血块形成，从而加强伤口部位的凝块形成 并且防止从伤口部位渗出，并且基本上禁止15个血液从伤口部位流出。
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公开(公告)号：US20080146984A1
公开(公告)日：2008-06-19
申请号：US12002401
申请日：2007-12-17
CPC分类号： A61F13/0276 , A61F13/0223 , A61F13/0226 , A61F17/00 , A61F2013/00472 , A61L15/425
摘要： An aqueous solution of polyacrylic acid is placed in a mold, frozen, and freeze-dried to form a sponge-like polyacrylic acid structure. The sponge-like polyacrylic acid structure is compressed by the application of heat and pressure to reduce the thickness and increase the density of the sponge-like polyacrylic acid structure to form a densified polyacrylic acid structure. The densified polyacrylic acid structure is preconditioned by heating to form a wound dressing. The wound dressing can be applied to control severe, life-threatening bleeding from a wound at a wound site of a person.
摘要翻译： 将聚丙烯酸水溶液置于模具中，冷冻并冷冻干燥以形成海绵状聚丙烯酸结构。 通过施加热和压力来压缩海绵状聚丙烯酸结构以减小厚度并增加海绵状聚丙烯酸结构的密度以形成致密聚丙烯酸结构。 致密聚丙烯酸结构通过加热预处理形成伤口敷料。 伤口敷料可用于控制人身伤口部位伤口严重的危及生命的出血。
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公开(公告)号：US08313474B2
公开(公告)日：2012-11-20
申请号：US12002401
申请日：2007-12-17
CPC分类号： A61F13/0276 , A61F13/0223 , A61F13/0226 , A61F17/00 , A61F2013/00472 , A61L15/425
摘要： An aqueous solution of polyacrylic acid is placed in a mold, frozen, and freeze-dried to form a sponge-like polyacrylic acid structure. The sponge-like polyacrylic acid structure is compressed by the application of heat and pressure to reduce the thickness and increase the density of the sponge-like polyacrylic acid structure to form a densified polyacrylic acid structure. The densified polyacrylic acid structure is preconditioned by heating to form a wound dressing. The wound dressing can be applied to control severe, life-threatening bleeding from a wound at a wound site of a person.
摘要翻译： 将聚丙烯酸水溶液置于模具中，冷冻并冷冻干燥以形成海绵状聚丙烯酸结构。 通过施加热和压力来压缩海绵状聚丙烯酸结构以减小厚度并增加海绵状聚丙烯酸结构的密度以形成致密聚丙烯酸结构。 致密聚丙烯酸结构通过加热预处理形成伤口敷料。 伤口敷料可用于控制人身伤口部位伤口严重的危及生命的出血。
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7.发明申请Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma 审中-公开用于制备，储存和施用冷冻干燥物质如冷冻干燥等离子体的装置和方法公开(公告)号：US20080234654A1
公开(公告)日：2008-09-25
申请号：US12077397
申请日：2008-03-19
申请人： Simon J. McCarthy , William D. Block , John W. Morgan , Lisa A. Buckley , Lance D. Hopman , Clinton B. Pepper
发明人： Simon J. McCarthy , William D. Block , John W. Morgan , Lisa A. Buckley , Lance D. Hopman , Clinton B. Pepper
IPC分类号： A61B19/00
CPC分类号： A61J1/10 , A61B50/10 , A61B50/13 , A61B50/30 , A61B90/96 , A61J1/1475 , A61J1/201 , A61J1/2013 , A61J1/2027 , A61J1/2037 , A61J1/2093 , A61J2205/10 , A61M2039/1061
摘要： A vessel receives a liquid material, which is freeze-dried in situ within the vessel. A gas permeable material carried by the vessel provides gas transport for sublimation during drying. After freeze drying, an oxygen-free inert gas is introduced into the vessel through the gas permeable material, to occupy the interior of the vessel with the freeze-dried material. The gas permeable material is covered, to trap the oxygen-free inert gas within the vessel with the freeze-dried material. The freeze-dried material is stored in the entrapped oxygen-free inert gas within the vessel for a storage period. The vessel receives a reconstituting liquid for mixing with the freeze-dried material, and conveys the reconstituted freeze-dried material from the vessel for administration to an individual.
摘要翻译： 容器接收液体材料，其在容器内原位冷冻干燥。 由容器携带的透气材料提供气体输送以在干燥期间升华。 冷冻干燥后，通过透气材料将无氧惰性气体引入容器中，以冻干材料占据容器的内部。 透气材料被覆盖，用冷冻干燥的材料捕集容器内的无氧惰性气体。 冷冻干燥的材料储存在容器内的夹带的无氧惰性气体中保存一段时间。 容器接收用于与冷冻干燥材料混合的重构液体，并将重构的冻干材料从容器输送到个体。
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8.发明申请Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma 失效用于制备，储存和施用冷冻干燥物质如冷冻干燥等离子体的装置和方法公开(公告)号：US20080234652A1
公开(公告)日：2008-09-25
申请号：US11725352
申请日：2007-03-19
IPC分类号： A61J1/10
CPC分类号： A61J1/10 , A61B50/10 , A61B50/13 , A61B50/30 , A61B90/96 , A61J1/1475 , A61J1/201 , A61J1/2013 , A61J1/2027 , A61J1/2037 , A61J1/2093 , A61J2205/10 , A61M2039/1061
摘要： A freeze-dried material is stored in a first chamber of a container along with a reconstituting liquid for the freeze-dried material, which is stored in a second chamber of the container. A sealing wall within the container forms a barrier between the first chamber and the second chamber preventing contact between the freeze-dried material and the reconstituting liquid. At least one valve assembly in the sealing wall selectively opens a region of the sealing wall to establish fluid flow communication between the first and second chambers, allowing the freeze dried material to be reconstituted. The reconstituted freeze-dried material can be administered from the same container to a recipient.
摘要翻译： 将冷冻干燥的材料与用于冷冻干燥材料的重构液体一起存储在容器的第一室中，该液体储存在容器的第二室中。 容器内的密封壁在第一腔室和第二腔室之间形成阻挡物，防止冷冻干燥材料与重构液体之间的接触。 密封壁中的至少一个阀组件选择性地打开密封壁的区域，以在第一和第二室之间建立流体流动连通，从而使冷冻干燥的材料重新构成。 重构的冻干材料可以从同一容器施用于接受者。
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9.发明授权公开(公告)号：US07371403B2
公开(公告)日：2008-05-13
申请号：US10743052
申请日：2003-12-23
CPC分类号： A61F13/0203 , A61F5/40 , A61F13/00063 , A61F13/0253 , A61F13/0256 , A61F13/0276 , A61F13/0289 , A61F13/36 , A61F17/00 , A61F2013/00106 , A61F2013/00221 , A61F2013/00463 , A61F2013/00468 , A61F2013/00472 , A61F2013/0054 , A61F2013/00659 , A61F2013/00676 , A61F2013/0071 , A61F2013/00719 , A61F2013/00931 , A61L15/28 , A61L15/425 , A61L2400/04 , C08L1/00 , C08L5/08
摘要： This invention is directed to advanced hemorrhage control wound dressings, and methods of using and producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe bleeding. The wound dressing for controlling severe bleeding is formed of a biomaterial comprising chitosan, a hydrophilic polymer, a polyacrylic polymer or a combination thereof. The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot formation at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of blood out of the wound site.
摘要翻译： 本发明涉及先进的出血控制伤口敷料，以及其使用和生产方法。 受试者伤口敷料由用于控制严重出血的非哺乳动物材料构成。 用于控制严重出血的伤口敷料由包含壳聚糖，亲水性聚合物，聚丙烯酸聚合物或其组合的生物材料形成。 本发明考虑的严重的威胁生命的出血通常是当将传统的纱布伤口敷料以常规压力施加到受试者伤口时不能被切断的类型。 伤口敷料能够通过粘附到伤口部位上来严重地伤害来自创伤的危及生命的出血的流动，以密封伤口，以加速伤口部位的血块形成，从而加强伤口部位的凝块形成 并且防止从伤口部位渗出，并且基本上禁止血液流出伤口部位。
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公开(公告)号：US08449520B2
公开(公告)日：2013-05-28
申请号：US12228745
申请日：2008-08-15
CPC分类号： F26B5/06 , A61B50/10 , A61B50/13 , A61B50/30 , A61B90/96 , A61J1/10 , A61J1/1475 , A61J1/201 , A61J1/2013 , A61J1/2027 , A61J1/2037 , A61J1/2093 , A61M2039/1061
摘要： A flexible container receives a liquid material, which is freeze-dried in situ within the flexible container. A gas permeable material that is separate from the flexible container provides gas transport for sublimation during drying and lyophilization. The gas permeable portion of the system can be isolated and removed from the flexible container post-lyophilzation The freeze-dried material is stored in the flexible container until administration is necessary. The flexible container receives a reconstituting liquid for mixing with the freeze-dried material, and conveys the reconstituted freeze-dried material from the flexible container for administration to an individual.
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