Reishi F3 sub fraction polysaccharides and methods of using same
    1.
    发明授权
    Reishi F3 sub fraction polysaccharides and methods of using same 有权
    Reishi F3分级多糖及其使用方法

    公开(公告)号:US08071105B2

    公开(公告)日:2011-12-06

    申请号:US12244709

    申请日:2008-10-02

    IPC分类号: A61K36/06

    摘要: The present disclosure relates to the discovery of methods of isolating subfractions of an F3 Reishi extract, and of administration of these novel isolates to eukaryotic cells in order to induce certain immumodulatory, hematopoeitic and tumor-inhibiting phenotypic changes in those eukaryotic cells, mediated through particular toll-like receptor (TLR) and other transmembrane receptors. F3 subfractions F301 and F331 have demonstrated that F331 is capable of activating at least TLR-2 while F301 is capable of activating at least TLR-2, TLR-4, and TLR-5.

    摘要翻译: 本公开涉及发现分离F3赖氏提取物的亚组分的方法,以及将这些新型分离物施用于真核细胞,以便诱导那些通过特异性介导的那些真核细胞中的某些免疫调节,造血细胞和肿瘤抑制表型变化 toll样受体(TLR)和其他跨膜受体。 F3亚分数F301和F331已经证明F331能够至少激活至少TLR-2,而F301能够至少激活TLR-2,TLR-4和TLR-5。

    REISHI F3 SUB FRACTION POLYSACCHARIDES AND METHODS OF USING SAME
    2.
    发明申请
    REISHI F3 SUB FRACTION POLYSACCHARIDES AND METHODS OF USING SAME 有权
    REISHI F3 SUB分级多糖和使用它们的方法

    公开(公告)号:US20090263897A1

    公开(公告)日:2009-10-22

    申请号:US12244709

    申请日:2008-10-02

    摘要: The present disclosure relates to the discovery of methods of isolating subfractions of an F3 Reishi extract, and of administration of these novel isolates to eukaryotic cells in order to induce certain immumodulatory, hematopoeitic and tumor-inhibiting phenotypic changes in those eukaryotic cells, mediated through particular toll-like receptor (TLR) and other transmembrane receptors. F3 subfractions F301 and F331 have demonstrated that F331 is capable of activating at least TLR-2 while F301 is capable of activating at least TLR-2, TLR-4, and TLR-5.

    摘要翻译: 本公开涉及发现分离F3赖氏提取物的亚组分的方法,以及将这些新型分离物施用于真核细胞,以便诱导那些通过特异性介导的那些真核细胞中的某些免疫调节,造血细胞和肿瘤抑制表型变化 toll样受体(TLR)和其他跨膜受体。 F3亚分数F301和F331已经证明F331能够至少激活至少TLR-2,而F301能够至少激活TLR-2,TLR-4和TLR-5。

    Fungal immunostimulatory compositions
    7.
    发明申请
    Fungal immunostimulatory compositions 有权
    真菌免疫刺激成分

    公开(公告)号:US20070231339A1

    公开(公告)日:2007-10-04

    申请号:US11549215

    申请日:2006-10-13

    IPC分类号: A61K38/16 A61K39/00 C12N5/02

    摘要: Methods are disclosed which are useful in increasing maturation of dendritic cells from CD14+ mononuclear cells, by contact with a composition comprising a fucose-containing glycoprotein fraction from Ganoderma lucidum. The extract can also be used for increasing production of a cytokine or a chemokine in a dendritic cell or CD19+ B cell. In addition, a fucose-containing glycoprotein fraction from Ganoderma lucidum can be administered to a subject identified as needing increased immunoglobulin, cytokine, or chemokine production.

    摘要翻译: 通过与含有来自灵芝的含岩藻糖的糖蛋白部分的组合物的接触,公开了可用于从CD14 + +单核细胞增加树突状细胞成熟的方法。 提取物也可用于增加树突状细胞或CD19 + B细胞中细胞因子或趋化因子的产生。 此外,来自灵芝的含岩藻糖的糖蛋白部分可以施用于被鉴定为需要增加的免疫球蛋白,细胞因子或趋化因子产生的受试者。

    LONGEVITY-PROMOTING EFFECTS OF ACETIC ACID AND REISHI POLYSACCHARIDE
    9.
    发明申请
    LONGEVITY-PROMOTING EFFECTS OF ACETIC ACID AND REISHI POLYSACCHARIDE 审中-公开
    强酸促进乙酸和赖氨酸多糖的作用

    公开(公告)号:US20090280062A1

    公开(公告)日:2009-11-12

    申请号:US12425319

    申请日:2009-04-16

    摘要: A composition of acetic acid and a composition of acetic acid and RF3 effecting expression of DAF-16 in C. elegans, wherein the at least acetic acid and the RF3 polysaccharide is effective to increase the life-span of C. elegans or humans. A method of regulating DAF-16 expression, comprising: administering a composition comprising at least acetic acid and RF3 polysaccharide; providing the composition to at least one receptor on a surface of a cell; causing an increase in expression of DAF-16. A method for screening a series of compounds or constituents parts of compounds including some antioxidant vitamins, traditional herb medicines, and vinegars using C. elegans as a live organism model to examine to determine if they have an impact the lifespan of C. elegans and the underlying mechanism(s) thereof.

    摘要翻译: 乙酸组合物和乙酸组合物和RF3在线虫中影响DAF-16的表达,其中至少乙酸和RF3多糖有效地增加秀丽隐杆线虫或人类的寿命。 一种调节DAF-16表达的方法,包括:施用至少包含乙酸和RF3多糖的组合物; 将组合物提供给细胞表面上的至少一种受体; 导致DAF-16的表达增加。 一种用于筛选一系列化合物或组分的化合物的方法,包括一些抗氧化维生素,传统草药和使用秀丽隐杆线虫作为活生物体模型的葡萄,以检查它们是否影响线虫的寿命 其基本机制。

    Glycosylation of exo-glycals
    10.
    发明授权
    Glycosylation of exo-glycals 失效
    外切糖的糖基化

    公开(公告)号:US07078520B2

    公开(公告)日:2006-07-18

    申请号:US10406979

    申请日:2003-04-04

    IPC分类号: C07H3/02 C07C13/00

    CPC分类号: C07H1/00

    摘要: This invention relates to a method of preparing a first alicyclic compound having a vinyl group on one alkyl ring carbon and an alkoxy, cycloalkoxy, heterocycloalkyoxy, aryloxy, or heteroaryloxy group on the same ring carbon; the method comprising reacting an aliphatic alcohol or an aromatic alcohol with a second alicyclic compound having an exo cyclic carbon-carbon double bond, wherein the non-ring olefinic carbon is substituted with a hydroxymethyl, thiomethyl, alkoxymethyl, aryloxymethyl, acyloxymethyl, alkylsulfonyloxymethyl, arylsulfonyloxymethyl, alkylsulfonylmethyl, arylsulfonylmethyl, halomethyl, or silyloxymethyl group.

    摘要翻译: 本发明涉及一种在同一环碳上一烷基环碳和烷氧基,环烷氧基,杂环烷氧基,芳氧基或杂芳氧基上具有乙烯基的第一脂环族化合物的制备方法; 所述方法包括使脂族醇或芳族醇与具有外环碳 - 碳双键的第二脂环族化合物反应,其中所述非环烯烃被羟甲基,硫代甲基,烷氧基甲基,芳氧基甲基,酰氧基甲基,烷基磺酰氧基甲基,芳基磺酰氧基甲基 ,烷基磺酰基甲基,芳基磺酰基甲基,卤代甲基或甲硅烷氧基甲基。