公开(公告)号：US20070100273A1

公开(公告)日：2007-05-03

申请号：US10581732

申请日：2004-12-08

Applicant: Shigeki Kawarabata ,  Hiroyuki Maeda ,  Yutaka Nakahara

Inventor： Shigeki Kawarabata ,  Hiroyuki Maeda ,  Yutaka Nakahara

IPC: A61M37/00

CPC classification number: A61M1/3627

Abstract: The extracorporeal blood circulating apparatus of the present invention includes: a closed-type venous reservoir having a blood storage chamber and a volume adjusting chamber that are disposed adjacently by partitioning a closed space formed by a housing; an adjusting liquid tank for storing an adjusting liquid that is connected to the volume adjusting chamber; and a blood pump that is connected to the blood storage chamber. In the housing, an inflow port for allowing blood to inflow and an outflow port for allowing blood to outflow are provided so as to communicate with the blood storage chamber, and an adjusting port for injecting and ejecting the adjusting liquid is provided so as to communicate with the volume adjusting chamber. The blood pump is connected via the outflow port, and the adjusting liquid tank is connected via the adjusting port. The closed space is partitioned by a flexible septum member so as to form the blood storage chamber and the volume adjusting chamber, and the adjusting liquid tank and the adjusting port are connected by a conduit member having a configuration that can adjust a flowing amount. Control of a blood storage amount to be most appropriate and easy adjustment are possible throughout all steps from before starting an extracorporeal blood circulation to terminating it.

Abstract translation: 本发明的体外血液循环装置包括：具有通过分隔由壳体形成的封闭空间相邻设置的血液储存室和容积调节室的封闭式静脉储存器; 用于存储连接到容积调节室的调节液体的调节液罐; 以及与血液存储室连接的血液泵。 在壳体中设置有允许血液流入的流入口和允许血液流出的流出口，与血液储存室连通，并且设置用于喷射和喷射调节液的调节口，以便连通 与音量调节室。 血泵通过流出口连接，调节液罐通过调节口连接。 封闭空间由柔性隔膜构件分隔开，形成血液储存室和容积调节室，并且调节液罐和调节口通过具有可调整流动量的构造的导管构件连接。 在开始体外血液循环之前的所有步骤中，可以控制血液存储量是最合适和容易的调节，以终止它。

公开(公告)号：US07651473B2

公开(公告)日：2010-01-26

申请号：US10581732

申请日：2004-12-08

Applicant: Shigeki Kawarabata ,  Hiroyuki Maeda ,  Yutaka Nakahara

Inventor： Shigeki Kawarabata ,  Hiroyuki Maeda ,  Yutaka Nakahara

IPC: A61M37/00

CPC classification number: A61M1/3627

Abstract: The extracorporeal blood circulating apparatus of the present invention includes: a closed-type venous reservoir having a blood storage chamber and a volume adjusting chamber that are disposed adjacently by partitioning a closed space formed by a housing; an adjusting liquid tank for storing an adjusting liquid that is connected to the volume adjusting chamber; and a blood pump that is connected to the blood storage chamber. In the housing, an inflow port for allowing blood to inflow and an outflow port for allowing blood to outflow are provided so as to communicate with the blood storage chamber, and an adjusting port for injecting and ejecting the adjusting liquid is provided so as to communicate with the volume adjusting chamber. The blood pump is connected via the outflow port, and the adjusting liquid tank is connected via the adjusting port. The closed space is partitioned by a flexible septum member so as to form the blood storage chamber and the volume adjusting chamber, and the adjusting liquid tank and the adjusting port are connected by a conduit member having a configuration that can adjust a flowing amount. Control of a blood storage amount to be most appropriate and easy adjustment are possible throughout all steps from before starting an extracorporeal blood circulation to terminating it.

Abstract translation: 本发明的体外血液循环装置包括：具有通过分隔由壳体形成的封闭空间相邻设置的血液储存室和容积调节室的封闭式静脉储存器; 用于存储连接到容积调节室的调节液体的调节液罐; 以及与血液存储室连接的血液泵。 在壳体中设置有允许血液流入的流入口和允许血液流出的流出口，与血液储存室连通，并且设置用于喷射和喷射调节液的调节口，以便连通 与音量调节室。 血泵通过流出口连接，调节液罐通过调节口连接。 封闭空间由柔性隔膜构件分隔开，形成血液储存室和容积调节室，并且调节液罐和调节口通过具有可调整流动量的构造的导管构件连接。 在开始体外血液循环之前的所有步骤中，可以控制血液存储量是最合适和容易的调节，以终止它。

公开(公告)号：US20090062716A1

公开(公告)日：2009-03-05

申请号：US11992839

申请日：2006-10-03

Applicant: Hiroyuki Maeda ,  Shigeki Kawarabata

Inventor： Hiroyuki Maeda ,  Shigeki Kawarabata

IPC: A61M1/10

CPC classification number: A61M1/3627 ,  A61M1/3636 ,  A61M2206/16

Abstract: An example of the closed-type blood reservoir of the invention is furnished with an outer shell in which a space is formed within its interior, a flexible septum that is interposed between a blood storage chamber shell and a volume adjustment chamber shell and that divides the space into a blood storage chamber for storing blood and a volume adjustment chamber for storing volume adjustment liquid, a blood inlet port, a blood outlet port, and a blood storage chamber air discharge port that are provided in the blood storage chamber shell such that they are in communication with the blood storage chamber, and a volume adjustment liquid port that is provided in the volume adjustment chamber shell such that it is in communication with the volume adjustment chamber, for injecting and ejecting the volume adjustment liquid into and away from the volume adjustment chamber, wherein the blood inlet port and the blood outlet port each are provided tangentially to the inner surface of the blood storage chamber shell such that blood that flows into the blood storage chamber from the blood inlet port can swirl along the inner surface of the blood storage chamber shell, and wherein the closed-type blood reservoir has a first blood flow route, provided in the blood storage chamber, that is formed by an outward concavity of the inner surface of the blood storage chamber shell, and that is in communication with the blood outlet port and at least part of which is formed in the direction of extension of the blood outlet port.

Abstract translation: 本发明的封闭式血液储存器的一个实例配备有外壳，其中在其内部形成有空间，柔性隔膜插入在血液储存室壳体和体积调节室壳体之间， 用于存储血液的血液存储室的空间和用于存储设置在储血室壳体中的容积调节液体，血液入口，血液出口和血液存储室空气排出口的容积调节室，使得它们 与血液存储室连通，以及容积调整液体口，其设置在容积调节室壳体内，使得其与容积调节室连通，用于将体积调节液体注入和排出体积 调节室，其中，所述血液入口和所述血液出口各自与所述血液塞的内表面相切地设置 使得血液从血液入口进入血液储存室的血液可以沿着血液储存室壳体的内表面旋转，并且其中闭合型血液储存器具有设置在血液中的第一血流路径 存储室，其由储血室壳体的内表面的向外凹部形成，并且与血液出口连通，并且其至少一部分在血液出口的延伸方向上形成。

公开(公告)号：US09011678B2

公开(公告)日：2015-04-21

申请号：US12278427

申请日：2007-01-29

Applicant: Junya Fujii ,  Shigeki Kawarabata

Inventor： Junya Fujii ,  Shigeki Kawarabata

IPC: B01D29/60 ,  A61M1/16 ,  A61M1/34

CPC classification number: A61M1/16 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3465

Abstract: The present invention provides a blood purification apparatus and a blood purification circuit, by which a circuit can be shared by different modes for performing respective continuous blood purification methods, a structure of the apparatus performing the continuous blood purification methods can be simplified, and CHF, CHD, CHDF, and ECUM can be performed. The blood purification apparatus and the blood purification circuit according to the present invention includes: a first supply fluid channel (3) having one end connected to a supply fluid container (1) containing a supply fluid flowing in the first supply fluid channel (3); a first branched part (4) connected to the other end of the first supply fluid channel (3); a first supply fluid pump (10a) connected to the first branched part (4); a second supply fluid channel (7) which has one end connected to the first supply fluid pump (10a) and the other end connected to a dialyzer (6) that filters and dialyzes blood, and in which the supply fluid from the first supply fluid pump (10a) flows; a second supply fluid pump (10b) connected to the first branched part (4); and a third supply fluid channel (9) in which a supply fluid from the second supply fluid pump (10b) flows, having one end connected to the second supply fluid pump (10b) and the other end connected to a vein side blood channel (16) in which blood taken from a patient flows.

Abstract translation: 本发明提供了一种血液净化装置和血液净化电路，通过该血液净化装置和血液净化回路，可以通过不同的模式共享用于进行各自的连续血液净化方法的电路，可以简化执行连续血液净化方法的装置的结构，并且CHF， 可以执行CHD，CHDF和ECUM。 根据本发明的血液净化装置和血液净化回路包括：第一供给流体通道（3），其一端与供给流体容器（1）连接，供给流体容器（1）包含在第一供给流体通道（3）中流动的供给流体， ; 连接到第一供应流体通道（3）的另一端的第一分支部分（4）; 连接到第一分支部分（4）的第一供应流体泵（10a）; 第二供应流体通道（7），其一端连接到第一供给流体泵（10a），另一端连接到过滤和透析血液的透析器（6），并且其中来自第一供给流体 泵（10a）流动; 连接到第一分支部分（4）的第二供给流体泵（10b）; 以及第三供应流体通道（9），其中来自第二供给流体泵（10b）的供给流体流动，其一端连接到第二供给流体泵（10b），另一端连接到静脉侧血液通道 16），其中从患者身上获取的血液流动。

公开(公告)号：US20060191841A1

公开(公告)日：2006-08-31

申请号：US10550070

申请日：2004-03-22

Applicant: Shigeki Kawarabata ,  Yutaka Katsuno ,  Shota Nakao

Inventor： Shigeki Kawarabata ,  Yutaka Katsuno ,  Shota Nakao

IPC: B01D27/00

CPC classification number: A61M1/3627 ,  Y10T156/1051

Abstract: A blood filter device includes: a housing (1) that includes a dome portion (2), a filter retaining portion (3), and a bottom portion (4); an inlet (5) provided on a lateral portion of the dome portion so as to allow blood to flow into the dome portion horizontally and along an inner wall of the dome portion; an air vent (6) provided at a top of the dome portion; a filter (8) for filtering a foreign substance in the blood, which is disposed in the filter retaining portion; and an outlet (7) for the blood, which is provided in the bottom portion. The blood filter device is configured so that the blood flows into the dome portion from the inlet, passes through the filter retaining portion, and then flows out from the outlet. The filter is formed of a sheet-like filter member that has been folded so as to have a plurality of pleats (8a) with enveloping surfaces connecting top ends of the respective pleats being flat so that the filter as a whole has a plate-shaped outer shape, and the filter is arranged so as to partition a cavity of the housing into a dome portion side and a bottom portion side. The blood filter device can remove impurities, thrombi, and the like in blood effectively and also can discharge air bubbles remaining in the filter easily.

Abstract translation: 血液过滤装置包括：包括穹顶部分（2），过滤器保持部分（3）和底部部分（4）的壳体（1）; 设置在所述圆顶部的侧部的入口（5），以使血液水平地并且沿着所述圆顶部的内壁流入所述圆顶部; 设置在所述圆顶部的顶部的排气口（6） 用于过滤血液中的异物的过滤器（8），其设置在过滤器保持部分中; 和用于血液的出口（7），其设置在底部。 血液过滤装置构成为使血液从入口流入圆顶部，通过过滤器保持部，然后从出口流出。 过滤器由已经折叠成具有多个褶皱（8a）的片状过滤构件形成，其中包围面连接各褶皱的顶端是平坦的，使得过滤器整体上具有板状过滤器， 并且所述过滤器被布置成将所述壳体的空腔分成拱顶部分侧和底部侧。 血液过滤装置能够有效地除去血液中的杂质，血栓等，还可以容易地排出留在过滤器中的气泡。

公开(公告)号：US20100078385A1

公开(公告)日：2010-04-01

申请号：US12594081

申请日：2008-03-25

Applicant: Shigeki Kawarabata ,  Noriaki Nakagawa ,  Junya Fujii ,  Shogo Kamito

Inventor： Shigeki Kawarabata ,  Noriaki Nakagawa ,  Junya Fujii ,  Shogo Kamito

IPC: B01D61/32 ,  A61M1/14 ,  A61M1/34 ,  B01D61/24 ,  B01D61/28

CPC classification number: A61M1/3643 ,  A61M1/16 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3644 ,  A61M1/3647 ,  A61M1/3649 ,  A61M2205/3331

Abstract: The present invention provides a blood circuit capable of automatically performing priming for safe treatments.The blood circuit includes: a hemofilter (56) purifying blood; a blood removal line that has an end connected to an inlet of the hemofilter (56) and that consists of a first blood removal line (84), a second blood removal line (88), and a third blood removal line (89); a blood return line that has an end connected to an outlet of the hemofilter (56) and that consists of the first blood return line (92) and the second blood return line (94); and an anticoagulant (bypass) line (90) reducing a difference between (a) a pressure of a priming fluid flowing in the blood removal line and (b) a pressure of the priming fluid flowing in the blood return line.

Abstract translation: 本发明提供能够自动进行灌注以进行安全处理的血液回路。 血液回路包括：血液净化器（56）净化血液; 血液清除管线，其一端与血液滤清器（56）的入口连接，由第一除血管线（84），第二除血管线（88）和第三除血管线（89）组成。 血液回流管线，其端部连接到血液滤清器（56）的出口，并且由第一血液回收管线（92）和第二血液回收管线（94）组成。 和抗凝血剂（旁路）管线（90），减少（a）在除血管线中流动的引发流体的压力和（b）在血液返回管线中流动的引发流体的压力之间的差异。

公开(公告)号：US07632290B2

公开(公告)日：2009-12-15

申请号：US10470432

申请日：2001-10-23

Applicant: Takasumi Nakamura ,  Manabu Okabe ,  Shigeki Kawarabata

Inventor： Takasumi Nakamura ,  Manabu Okabe ,  Shigeki Kawarabata

IPC: A61M29/00

CPC classification number: A61B17/12131 ,  A61B17/11 ,  A61B17/1204 ,  A61B17/12045 ,  A61B17/12136 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/12127

Abstract: A blood vessel anastomosing auxiliary tool consisting of a flexible hollow conduit having opening ends at the opposite ends thereof, and comprising, on the outer surface of the conduit, at least two bulky portions, a retrieving means for retrieving the conduit from within a blood vessel, and desirably a guide wire for guiding the conduit when it is inserted into a blood vessel, characterized in that the conduit has flexibility and self-restoring property, and the bulky portions are disposed on the conduit eccentrically, the use of the blood vessel anastomosing auxiliary tool permitting a quick and positive anastomosis between a bypassed blood vessel and a bypassing blood vessel while a blood flow remaining in a portion between the central and peripheral sides of the bypassed blood vessel is secured during a blood vessel bypassing operation, and further ensuring an unobstructed blood vessel anastomosing to allow an easier practicing operation (anastomosing) than those by conventional tools.

Abstract translation: 一种血管吻合辅助工具，其由在其相对端处具有开口端的柔性中空导管组成，并且在导管的外表面上包括至少两个笨重部分，用于从血管内取回导管的回收装置 并且理想地是用于在导管插入血管时引导导管，其特征在于，所述导管具有柔性和自恢复性，并且笨重部分偏心地设置在导管上，使用血管吻合 辅助工具允许在旁路血管和旁路血管之间快速和积极的吻合，同时在血管旁路操作期间确保在旁路血管的中央和外周之间的部分中的血流量，并进一步确保 无阻塞的血管吻合，允许更容易的练习操作（吻合）比常规的 ols。

公开(公告)号：US08147753B2

公开(公告)日：2012-04-03

申请号：US12593707

申请日：2008-03-28

Applicant: Minoru Tanaka ,  Tomokazu Niitsuma ,  Shigeki Kawarabata ,  Takashi Matsushita

Inventor： Minoru Tanaka ,  Tomokazu Niitsuma ,  Shigeki Kawarabata ,  Takashi Matsushita

IPC: A61M1/00 ,  A61M37/00

CPC classification number: A61M1/1698 ,  A61M1/1625 ,  B01D53/22 ,  B01D63/02 ,  B01D2313/38 ,  B01D2325/38

Abstract: A heat exchanger includes a plurality of tubes 2 through an inner cavity of which a heat-transfer medium liquid flows, a sealing member 6 that seals the plurality of tubes 2 while exposing both ends thereof, with a blood channel passing outside each of the tubes 2 being formed in a central portion in the axial direction of the tubes, and a housing 5 that accommodates the tubes 2 sealed with the sealing member 6. The heat exchanger further includes a hollow fiber membrane 3 that is formed of a plurality of hydrophobic and gas permeable hollow fibers 4 and that is disposed on at least one of an entrance side and an exit side of the blood channel in the housing 5 so that a liquid flowing through the blood channel passes through the hollow fiber membrane 3. The housing 5 includes openings 10 for exposing open ends of each of the hollow fibers 4 forming the hollow fiber membrane 3 to the outside, and gaps between an inner side of the openings and the hollow fibers 4 are sealed. Air can be removed while suppressing a reduction in the heat exchange efficiency.

Abstract translation: 热交换器包括通过其中传热介质液体流动的内腔的多个管2，密封件6，其密封多个管2，同时暴露其两端，通过每个管外的血液通道 2形成在管的轴向的中心部分和容纳用密封构件6密封的管2的壳体5.热交换器还包括中空纤维膜3，该中空纤维膜3由多个疏水性和 透气性中空纤维4，其设置在壳体5中的血液通道的入口侧和出口侧的至少一方，使得流过血液通道的液体通过中空纤维膜3.壳体5包括 用于将形成中空纤维膜3的每个中空纤维4的开口端暴露于外部的开口10，并且开口的内侧和中空纤维4之间的间隙被密封。 可以在抑制热交换效率的降低的同时除去空气。

公开(公告)号：US20100114004A1

公开(公告)日：2010-05-06

申请号：US12593707

申请日：2008-03-28

Applicant: Minoru Tanaka ,  Tomokazu Niitsuma ,  Shigeki Kawarabata ,  Takashi Matsushita

Inventor： Minoru Tanaka ,  Tomokazu Niitsuma ,  Shigeki Kawarabata ,  Takashi Matsushita

IPC: A61M1/36 ,  A61M1/14

CPC classification number: A61M1/1698 ,  A61M1/1625 ,  B01D53/22 ,  B01D63/02 ,  B01D2313/38 ,  B01D2325/38

Abstract: A heat exchanger includes a plurality of tubes 2 through an inner cavity of which a heat-transfer medium liquid flows, a sealing member 6 that seals the plurality of tubes 2 while exposing both ends thereof, with a blood channel passing outside each of the tubes 2 being formed in a central portion in the axial direction of the tubes, and a housing 5 that accommodates the tubes 2 sealed with the sealing member 6. The heat exchanger further includes a hollow fiber membrane 3 that is formed of a plurality of hydrophobic and gas permeable hollow fibers 4 and that is disposed on at least one of an entrance side and an exit side of the blood channel in the housing 5 so that a liquid flowing through the blood channel passes through the hollow fiber membrane 3. The housing 5 includes openings 10 for exposing open ends of each of the hollow fibers 4 forming the hollow fiber membrane 3 to the outside, and gaps between an inner side of the openings and the hollow fibers 4 are sealed. Air can be removed while suppressing a reduction in the heat exchange efficiency.

Abstract translation: 热交换器包括通过其中传热介质液体流动的内腔的多个管2，密封件6，其密封多个管2，同时暴露其两端，通过每个管外的血液通道 2形成在管的轴向的中心部分和容纳用密封构件6密封的管2的壳体5.热交换器还包括中空纤维膜3，该中空纤维膜3由多个疏水性和 透气性中空纤维4，其设置在壳体5中的血液通道的入口侧和出口侧的至少一方，使得流过血液通道的液体通过中空纤维膜3.壳体5包括 用于将形成中空纤维膜3的每个中空纤维4的开口端暴露于外部的开口10，并且开口的内侧和中空纤维4之间的间隙被密封。 可以在抑制热交换效率的降低的同时除去空气。

公开(公告)号：US08877063B2

公开(公告)日：2014-11-04

申请号：US12594081

申请日：2008-03-25

Applicant: Shigeki Kawarabata ,  Noriaki Nakagawa ,  Junya Fujii ,  Shogo Kamito

Inventor： Shigeki Kawarabata ,  Noriaki Nakagawa ,  Junya Fujii ,  Shogo Kamito

IPC: B01D11/00 ,  B01D61/00 ,  C02F1/44 ,  A61M1/36 ,  A61M1/34

CPC classification number: A61M1/3643 ,  A61M1/16 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3644 ,  A61M1/3647 ,  A61M1/3649 ,  A61M2205/3331

Abstract: A blood circuit capable of automatically performing priming for safe treatments. The blood circuit includes: a hemofilter (56) purifying blood; a blood removal line that has an end connected to an inlet of the hemofilter (56) and that includes a first blood removal line (84), a second blood removal line (88), and a third blood removal line (89); a blood return line that has an end connected to an outlet of the hemofilter (56) and that includes the first blood return line (92) and the second blood return line (94); and an anticoagulant (bypass) line (90) reducing a difference between (a) a pressure of a priming fluid flowing in the blood removal line and (b) a pressure of the priming fluid flowing in the blood return line.

Abstract translation: 能够自动进行灌注以进行安全治疗的血液回路。 血液回路包括：血液净化器（56）净化血液; 具有连接到血液滤液器（56）的入口并且包括第一除血管线（84），第二除血管线（88）和第三除血管线（89）的端部的除血管线; 血液回流管线，其端部连接到血液滤清器（56）的出口，并且包括第一血液回输管线（92）和第二血液回收管线（94）; 和抗凝血剂（旁路）管线（90），减少（a）在除血管线中流动的引发流体的压力和（b）在血液返回管线中流动的引发流体的压力之间的差异。