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公开(公告)号：US20230113588A1
公开(公告)日：2023-04-13
申请号：US17883255
申请日：2022-08-08
发明人： Nicholas David Peter COSFORD , Dhanya RAVEENDRA-PANICKAR , Douglas J. SHEFFLER , John Howard HUTCHINSON , Reto Andreas GADIENT
IPC分类号： C07D243/14 , A61K31/4196 , A61K31/426 , A61K31/427 , A61K31/433 , C07D217/06 , C07D417/04 , C07D249/08 , C07D277/20 , C07D285/08 , C07D403/12 , C07D233/54 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/04 , C07D239/26 , C07D409/04 , C07D243/12 , C07D271/06 , C07D275/02 , C07D277/30 , A61K31/505 , A61K31/506 , C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D277/26 , C07D307/38 , C07D333/24 , C07D401/14 , C07D405/10 , C07D409/02 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/10 , C07D417/14 , A61P25/00
摘要： Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
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2.发明申请公开(公告)号：US20200347021A1
公开(公告)日：2020-11-05
申请号：US16817209
申请日：2020-03-12
发明人： Nicholas David Peter COSFORD , Dhanya RAVEENDRA-PANICKAR , Douglas J. SHEFFLER , John Howard HUTCHINSON , Reto Andreas GADIENT
IPC分类号： C07D243/14 , A61K31/4196 , A61K31/426 , A61K31/427 , A61K31/433 , C07D217/06 , C07D417/04 , C07D249/08 , C07D277/20 , C07D285/08 , C07D403/12 , C07D233/54 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/04 , C07D239/26 , C07D409/04 , C07D243/12 , C07D271/06 , C07D275/02 , C07D277/30 , A61K31/505 , A61K31/506 , C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D277/26 , C07D307/38 , C07D333/24 , C07D401/14 , C07D405/10 , C07D409/02 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/10 , C07D417/14 , A61P25/00
摘要： Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
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