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公开(公告)号：US20200317731A1
公开(公告)日：2020-10-08
申请号：US16740240
申请日：2020-01-10
IPC分类号： C07K5/083 , C07D498/04 , C07D513/04 , C07D487/04 , C07D487/14 , C07D498/10
摘要： Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPs), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
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2.发明申请公开(公告)号：US20200347021A1
公开(公告)日：2020-11-05
申请号：US16817209
申请日：2020-03-12
发明人： Nicholas David Peter COSFORD , Dhanya RAVEENDRA-PANICKAR , Douglas J. SHEFFLER , John Howard HUTCHINSON , Reto Andreas GADIENT
IPC分类号： C07D243/14 , A61K31/4196 , A61K31/426 , A61K31/427 , A61K31/433 , C07D217/06 , C07D417/04 , C07D249/08 , C07D277/20 , C07D285/08 , C07D403/12 , C07D233/54 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/04 , C07D239/26 , C07D409/04 , C07D243/12 , C07D271/06 , C07D275/02 , C07D277/30 , A61K31/505 , A61K31/506 , C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D277/26 , C07D307/38 , C07D333/24 , C07D401/14 , C07D405/10 , C07D409/02 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/10 , C07D417/14 , A61P25/00
摘要： Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
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公开(公告)号：US20230113588A1
公开(公告)日：2023-04-13
申请号：US17883255
申请日：2022-08-08
发明人： Nicholas David Peter COSFORD , Dhanya RAVEENDRA-PANICKAR , Douglas J. SHEFFLER , John Howard HUTCHINSON , Reto Andreas GADIENT
IPC分类号： C07D243/14 , A61K31/4196 , A61K31/426 , A61K31/427 , A61K31/433 , C07D217/06 , C07D417/04 , C07D249/08 , C07D277/20 , C07D285/08 , C07D403/12 , C07D233/54 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/04 , C07D239/26 , C07D409/04 , C07D243/12 , C07D271/06 , C07D275/02 , C07D277/30 , A61K31/505 , A61K31/506 , C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D277/26 , C07D307/38 , C07D333/24 , C07D401/14 , C07D405/10 , C07D409/02 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/10 , C07D417/14 , A61P25/00
摘要： Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
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公开(公告)号：US20190135861A1
公开(公告)日：2019-05-09
申请号：US16031837
申请日：2018-07-10
IPC分类号： C07K5/083 , C07D498/10 , C07D487/14 , C07D487/04 , C07D513/04 , C07D498/04
CPC分类号： C07K5/0806 , A61K38/00 , C07D487/04 , C07D487/14 , C07D498/04 , C07D498/10 , C07D513/04
摘要： Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPs), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
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公开(公告)号：US20230295181A1
公开(公告)日：2023-09-21
申请号：US17997461
申请日：2021-04-29
发明人： Nicholas David Peter COSFORD , Dominik HEIMANN , Peter TERIETE , Sumit Kumar CHANDA , Lars PACHE , Laurent Jean Stephane DE BACKER , Nicole BATA
IPC分类号： C07D498/04 , C07D513/04 , C07D487/04 , C07D487/22 , A61P35/00
CPC分类号： C07D498/04 , C07D513/04 , C07D487/04 , C07D487/22 , A61P35/00
摘要： Provided herein are compounds that modulate the activity of melanoma inhibitor of apoptosis (ML-IAP) protein, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
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公开(公告)号：US20230115837A1
公开(公告)日：2023-04-13
申请号：US17773749
申请日：2020-11-06
发明人： Nicholas David Peter COSFORD , Dominik HEIMANN , Peter TERIETE , Sumit Kumar CHANDA , Lars PACHE , Nicole BATA
摘要： Provided herein are compounds that modulate the activity of inhibitor of apoptosis (IAPs) proteins, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
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公开(公告)号：US20220119444A1
公开(公告)日：2022-04-21
申请号：US17389171
申请日：2021-07-29
IPC分类号： C07K5/083 , C07D498/04 , C07D513/04 , C07D487/04 , C07D487/14 , C07D498/10
摘要： Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPs), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
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