公开(公告)号：US09987427B1

公开(公告)日：2018-06-05

申请号：US14746301

申请日：2015-06-22

申请人： Sandia Corporation

发明人： Ronen Polsky ,  Philip Rocco Miller ,  Thayne L. Edwards

IPC分类号： A61M5/172 ,  A61B10/00 ,  A61B5/145 ,  A61M37/00 ,  A61B5/157

CPC分类号： A61M5/1723 ,  A61B5/157 ,  A61M37/0015 ,  A61M2005/1726 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2202/048 ,  A61M2202/30

摘要： The present invention is directed to devices, systems, and methods for detecting and/or monitoring one or more markers in a sample. In particular, such devices integrate a plurality of hollow needles configured to extract or obtain a fluid sample from a subject, as well as transducers to detect a marker of interest.

公开(公告)号：US20160095541A1

公开(公告)日：2016-04-07

申请号：US14965755

申请日：2015-12-10

申请人： The Regents of the University of California ,  North Carolina State University ,  Sandia Corporation

发明人： Joseph Wang ,  Joshua Ray Windmiller ,  Roger Narayan ,  Philip Miller ,  Ronen Polsky ,  Thayne L. Edwards

IPC分类号： A61B5/1473 ,  A61B5/00 ,  A61B5/145

CPC分类号： A61B5/1473 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/150984 ,  A61B5/157 ,  A61B5/4845 ,  A61B5/6833 ,  A61B5/685 ,  A61B5/7282 ,  A61B10/0045 ,  A61B2010/008 ,  A61B2562/028 ,  A61B2562/046 ,  A61M5/158 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2037/0023 ,  A61M2037/003 ,  G01N33/48785

摘要： Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.

摘要翻译： 公开了用于生物传感和药物递送技术的方法，结构和系统。 在一个方面，用于检测分析物和/或将生物化学物质释放到生物流体中的装置可以包括中空针阵列，其中每个针包括突出的针结构，其包括形成中空内部的外壁和在 暴露中空内部的突出针结构的末端以及外壁内的探针与通过开口与探针接触以产生探针感测信号的一种或多种化学或生物物质相互作用，并产生阵列 分别耦合到中空针阵列的探针的导线，每根线都是导电的，以传输由相应探针产生的探针感测信号。

公开(公告)号：US20160296149A1

公开(公告)日：2016-10-13

申请号：US15078870

申请日：2016-03-23

申请人： Sandia Corporation ,  STC.UNM

发明人： Ronen Polsky ,  Philip Rocco Miller ,  Justin T. Baca

IPC分类号： A61B5/145 ,  A61B5/1477 ,  A61B5/1455

CPC分类号： A61B5/14514 ,  A61B5/14525 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1468 ,  A61B5/165 ,  A61B2010/008 ,  A61M2037/0061

摘要： A transdermal and/or intradermal diagnostic device comprising a combined hollow microneedle interstitial fluid (IF) extraction device and a detector can monitor biomarkers in-situ. For example, electrode transducers with optimally arrayed and designed microneedles can be combined with a suitable pumping method to determine biomarker levels in human subjects under intense physical exertion to monitor metabolic stress and fatigue. The device can perform real-time, in-situ measurements of lactate in human subjects. Monitoring of other biomarkers is straightforward.

摘要翻译： 包括组合的中空微针间质液（IF）提取装置和检测器的透皮和/或皮内诊断装置可以原位监测生物标志物。 例如，具有最佳排列和设计的微针的电极传感器可以与合适的泵送方法结合，以确定强烈体力劳动下人体受试者的生物标志物水平，以监测代谢应激和疲劳。 该装置可以对人类受试者的乳酸进行实时，原位测量。 监测其他生物标志物是直接的。

公开(公告)号：US20180338713A1

公开(公告)日：2018-11-29

申请号：US14538096

申请日：2014-11-11

申请人： Sandia Corporation

发明人： Ronen Polsky ,  Philip Rocco Miller ,  Matthew W. Moorman ,  Susan M. Brozik ,  Ronald P. Manginell ,  David R. Wheeler ,  Thayne L. Edwards

IPC分类号： A61B5/1473 ,  A61B5/1459 ,  A61B5/00 ,  A61B5/145 ,  A61B5/157 ,  A61B5/155 ,  A61B5/15 ,  A61B10/00

摘要： The present invention is directed to devices and methods for detecting one or more markers in a sample. In particular, such devices integrate a plurality of hollow needles configured to extract or obtain a fluid sample from a subject, as well as transducers to detect a marker of interest (e.g., an electrolyte). In some embodiments, the needles are provided as a disposable cartridge.

公开(公告)号：US09743870B2

公开(公告)日：2017-08-29

申请号：US14965755

申请日：2015-12-10

申请人： The Regents of the University of California ,  North Carolina State University ,  Sandia Corporation

发明人： Joseph Wang ,  Joshua Ray Windmiller ,  Roger Narayan ,  Philip Miller ,  Ronen Polsky ,  Thayne L. Edwards

IPC分类号： A61B5/1473 ,  A61M5/158 ,  A61B5/00 ,  A61B5/145 ,  G01N33/487 ,  A61B5/1486 ,  A61B5/15 ,  A61B5/157 ,  A61B10/00 ,  A61M5/172 ,  A61M37/00

CPC分类号： A61B5/1473 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/150984 ,  A61B5/157 ,  A61B5/4845 ,  A61B5/6833 ,  A61B5/685 ,  A61B5/7282 ,  A61B10/0045 ,  A61B2010/008 ,  A61B2562/028 ,  A61B2562/046 ,  A61M5/158 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2037/0023 ,  A61M2037/003 ,  G01N33/48785

摘要： Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.

公开(公告)号：US09533887B1

公开(公告)日：2017-01-03

申请号：US13790524

申请日：2013-03-08

申请人： Sandia Corporation

发明人： Ronen Polsky ,  Xiaoyin Xiao ,  David Bruce Burckel ,  David R. Wheeler ,  Susan M. Brozik ,  Thomas Edwin Beechem

IPC分类号： B05D5/00 ,  C01B31/04

CPC分类号： C01B32/184 ,  C01B31/0438 ,  C01B32/182 ,  C01B32/20 ,  C01P2004/30

摘要： A patterned graphene or graphitic body is produced by providing a three-dimensionally patterned carbonaceous body; coating the body with a catalytic metal whereby is formed a coating having an inner surface proximal the body and an outer surface distal the body; and annealing the coated body under time and temperature conditions effective to form a graphene or graphitic layer on the outer surface of the catalytic metal coating.

摘要翻译： 通过提供三维图案化的碳质体制造图案化的石墨烯或石墨体; 用催化金属涂覆本体，由此形成具有靠近主体的内表面和远离主体的外表面的涂层; 并且在有效地在催化金属涂层的外表面上形成石墨烯或石墨层的时间和温度条件下退火涂覆体。