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公开(公告)号：US20170205396A1
公开(公告)日：2017-07-20
申请号：US15406606
申请日：2017-01-13
CPC分类号： A61K35/22 , C12N5/0687 , C12N5/0697 , C12N2501/115 , C12N2501/155 , C12N2501/235 , C12N2501/727 , C12N2501/91 , C12N2503/04 , C12N2513/00 , G01N2500/10
摘要： Provided herein are self-renewable nephron progenitor cell (srNPC) and methods for making and using.
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公开(公告)号：US20190225991A1
公开(公告)日：2019-07-25
申请号：US16318120
申请日：2017-07-14
发明人： Juan Carlos IZPISUA BELMONTE , Keiichiro SUZUKI , Reyna HERNANDEZ-BENITEZ , Jun WU , Yuji TSUNEKAWA
IPC分类号： C12N15/90 , C12N15/11 , A61P35/00 , A61K48/00 , C12N15/113 , C12N15/86 , C12N9/22 , A61P25/28
摘要： Disclosed herein are homology-independent targeted integration methods of integrating an exogenous DNA sequence into a genome of a non-dividing cell and compositions for such methods. Methods herein comprise contacting the non-dividing cell with a composition comprising a targeting construct comprising the exogenous DNA sequence and a targeting sequence, a complementary strand oligonucleotide homologous to the targeting sequence, and a nuclease, thereby altering the genome of the non-dividing cell.
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公开(公告)号：US20170283777A1
公开(公告)日：2017-10-05
申请号：US15468006
申请日：2017-03-23
CPC分类号： C12N5/0604 , A01K67/0271 , A01K2207/12 , A01K2227/101 , A01K2227/108 , C12N5/0696 , C12N2501/999 , C12N2506/1307 , C12N2510/00 , C12N2800/108
摘要： Disclosed herein are chimeric mammals, such as a chimeric mammal comprising cells derived from at least a first mammal and a second mammal, wherein the cells from the first mammal comprise a genetic modification at one or more loci and the cells from the second mammal form at least one organ or tissue, wherein the first and second mammals are different species.
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