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公开(公告)号：US20200158720A1
公开(公告)日：2020-05-21
申请号：US16707501
申请日：2019-12-09
申请人： STC.UNM
发明人： David G. Whitten , Harry Craig Pappas , Eric H. Hill , Yue Zhang , Eva Yung Hua Chi , Arjun Thapa , Ying Wang , Patrick L. Donabedian , Kiran Bhaskar
摘要： Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.
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公开(公告)号：US20190116797A1
公开(公告)日：2019-04-25
申请号：US16192248
申请日：2018-11-15
发明人： David G. Whitten , Kirk S. Schanze , Anand Parthasarathy , Eunkyung Ji , Motokatsu Ogawa , Thomas S. Corbitt , Dimitri Dascier , Ying Wang , Linnea K. Ista , Eric H. Hill
IPC分类号： A01N43/90 , C08G61/02 , C07D409/14 , C08G75/00 , A01N25/08 , A01N33/10 , C07C217/14 , A01N25/10 , A01N33/12 , A01N41/04 , A01N43/10 , C08G61/12 , C07D487/08 , C07D333/16 , C07C309/24 , C07C217/20 , C07C309/11
摘要： The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.
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公开(公告)号：US10058099B2
公开(公告)日：2018-08-28
申请号：US15368148
申请日：2016-12-02
发明人： David G. Whitten , Kirk S. Schanze , Eunkyung Ji , Dimitri Dascier , Anand Parthasarathy , Thomas S. Corbitt , Kirsten Cicotte , Elizabeth LeBleu Dirk , Xuzhi Zhu
IPC分类号： A01N43/90 , A61L15/46 , A01N33/12 , A01N43/10 , A01N25/34 , A01N37/10 , A61L15/20 , D01H7/00
CPC分类号： A01N43/90 , A01N25/34 , A01N33/12 , A01N37/10 , A01N43/10 , A61L15/20 , A61L15/46 , A61L2300/208 , A61L2300/404 , D01H7/00 , A01N59/00 , A01N2300/00
摘要： The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products.
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公开(公告)号：US09968698B2
公开(公告)日：2018-05-15
申请号：US14533612
申请日：2014-11-05
申请人： STC.UNM
发明人： David G. Whitten , Eric H. Hill , Harry C. Pappas
摘要： The invention relates to compositions including a charged oligo-phenylene ethynylene singlet-oxygen sensitizer and an oppositely-charged surfactant, which show an enhanced biocidal activity relative to a comparable concentration of the oligo-phenylene ethynylene without the oppositely-charged surfactant. The enhancement of biocidal activity is observed with an anionic oligo-phenylene ethynylene in the presence of a cationic surfactant such as TTAB, and with a cationic oligo-phenylene ethynylene in the presence of an anionic surfactant such as SDS.
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公开(公告)号：US10750746B2
公开(公告)日：2020-08-25
申请号：US16192248
申请日：2018-11-15
发明人： David G. Whitten , Kirk S. Schanze , Anand Parthasarathy , Eunkyung Ji , Motokatsu Ogawa , Thomas S. Corbitt , Dimitri Dascier , Ying Wang , Linnea K. Ista , Eric H. Hill
IPC分类号： A01N43/90 , C07C217/14 , C07C309/11 , A01N25/10 , C07D409/14 , C07C217/20 , C07C309/24 , C07D333/16 , C07D487/08 , C08G61/02 , C08G75/00 , C08G61/12 , A01N25/08 , A01N33/10 , A01N33/12 , A01N41/04 , A01N43/10
摘要： The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.
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公开(公告)号：US10174042B2
公开(公告)日：2019-01-08
申请号：US15348756
申请日：2016-11-10
发明人： David G. Whitten , Kirk S. Schanze , Anand Parthasarathy , Eunkyung Ji , Motokatsu Ogawa , Thomas S. Corbitt , Dimitri Dascier , Ying Wang , Linnea K. Ista , Eric H. Hill
IPC分类号： C07D487/08 , C07C217/14 , C07C309/11 , C07C217/20 , C07C309/24 , C07D333/16 , C08G61/02 , C08G75/00 , C08G61/12
摘要： The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.
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公开(公告)号：US09005540B2
公开(公告)日：2015-04-14
申请号：US14092409
申请日：2013-11-27
发明人： Kirk S. Schanze , Motokatsu Ogawa , Jonathan Robert Sommer , David G. Whitten , Thomas S. Corbitt
CPC分类号： A01N25/28 , A01N25/00 , A01N25/10 , A01N25/34 , A01N43/90 , A61L2/23 , Y10S977/712 , Y10S977/903 , Y10T428/2982 , A01N41/04 , A01N2300/00
摘要： Hollow conjugated polyelectrolyte (HCPE) microcapsules contain at least one conjugated polyelectrolyte and at least one other polyelectrolyte of complementary charge and the microcapsule has a hollow core. The conjugated polyelectrolyte is a polymer with a multiplicity of charged repeating units where a portion of the charged repeating units form a pi-conjugated sequence. The complementary polyelectrolyte is a polymer with a complementary charged repeating unit to the charged repeating units of the conjugated polyelectrolyte. The HCPE microcapsules can be formed by successively coating a sacrificial core with alternating layers of complementary polyelectrolytes, at least one of which is a conjugated polyelectrolyte. The sacrificial core can be removed to form the hollow center of a HCPE microcapsule. The HCPE microcapsules can be contacted with a medium containing microbes where the HCPE microcapsules associate with the microbes and efficiently kill the microbes when irradiated with light or other electromagnetic radiation.
摘要翻译： 中空共轭聚电解质（HCPE）微胶囊含有至少一种共轭聚电解质和至少一种其他互补电荷的聚电解质，微胶囊具有中空芯。 共轭聚电解质是具有多个带电重复单元的聚合物，其中一部分带电重复单元形成π-共轭序列。 互补聚电解质是与共轭聚电解质的带电重复单元具有互补的带电重复单元的聚合物。 HCPE微胶囊可以通过连续地涂覆具有互补聚电解质交替层的牺牲芯形成，其中至少一种是共轭聚电解质。 可以去除牺牲芯以形成HCPE微胶囊的中空中心。 HCPE微胶囊可以与含有微生物的培养基接触，其中HCPE微胶囊与微生物结合，并在用光或其他电磁辐射照射时有效杀死微生物。
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公开(公告)号：US20140086795A1
公开(公告)日：2014-03-27
申请号：US14092409
申请日：2013-11-27
发明人： Kirk S. Schanze , Motokatsu Ogawa , Jonathan Robert Sommer , David G. Whitten , Thomas S. Corbitt
CPC分类号： A01N25/28 , A01N25/00 , A01N25/10 , A01N25/34 , A01N43/90 , A61L2/23 , Y10S977/712 , Y10S977/903 , Y10T428/2982 , A01N41/04 , A01N2300/00
摘要： Hollow conjugated polyelectrolyte (HCPE) microcapsules contain at least one conjugated polyelectrolyte and at least one other polyelectrolyte of complementary charge and the microcapsule has a hollow core. The conjugated polyelectrolyte is a polymer with a multiplicity of charged repeating units where a portion of the charged repeating units form a pi-conjugated sequence. The complementary polyelectrolyte is a polymer with a complementary charged repeating unit to the charged repeating units of the conjugated polyelectrolyte. The HCPE microcapsules can be formed by successively coating a sacrificial core with alternating layers of complementary polyelectrolytes, at least one of which is a conjugated polyelectrolyte. The sacrificial core can be removed to form the hollow center of a HCPE microcapsule. The HCPE microcapsules can be contacted with a medium containing microbes where the HCPE microcapsules associate with the microbes and efficiently kill the microbes when irradiated with light or other electromagnetic radiation.
摘要翻译： 中空共轭聚电解质（HCPE）微胶囊含有至少一种共轭聚电解质和至少一种其他互补电荷的聚电解质，微胶囊具有中空芯。 共轭聚电解质是具有多个带电重复单元的聚合物，其中一部分带电重复单元形成π-共轭序列。 互补聚电解质是与共轭聚电解质的带电重复单元具有互补的带电重复单元的聚合物。 HCPE微胶囊可以通过连续地涂覆具有互补聚电解质交替层的牺牲芯形成，其中至少一种是共轭聚电解质。 可以去除牺牲芯以形成HCPE微胶囊的中空中心。 HCPE微胶囊可以与含有微生物的培养基接触，其中HCPE微胶囊与微生物结合，并在用光或其他电磁辐射照射时有效杀死微生物。
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公开(公告)号：US10533991B2
公开(公告)日：2020-01-14
申请号：US15125896
申请日：2015-03-13
申请人： STC.UNM
发明人： David G. Whitten , Harry Pappas , Eric H. Hill , Yue Zhang , Eva Yung Hua Chi , Arjun Thapa , Ying Wang , Patrick L. Donabedian , Kiran Bhaskar
摘要： Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethynylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.
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公开(公告)号：US20180020663A1
公开(公告)日：2018-01-25
申请号：US15668390
申请日：2017-08-03
发明人： David G. Whitten , Harry Craig Pappas , Eric H. Hill , Kirk S. Schanze , Anand Parthasarathy , Yun Huang , Thomas S. Corbitt
CPC分类号： A01N43/50 , A01N33/08 , A01N33/12 , A01N43/90 , A61L15/24 , A61L15/46 , A61L2300/404 , A61L2420/02 , C07D233/64 , C07D409/06
摘要： Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure —R1—Y—R2—Z—. At each occurrence, R1 is independently chosen from 1,4-bonded phenylene substituted by —X—R3—R4 j times and 2,5-bonded thiophene substituted by —X—R3—R4 j times. At each occurrence, Y is independently chosen from a bond and —C≡C—. At each occurrence, R2 is independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and —C≡C—. The variables j, R3, and R4 are as defined herein.
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