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公开(公告)号：US10000754B2
公开(公告)日：2018-06-19
申请号：US15637579
申请日：2017-06-29
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1137 , C12N15/1138 , C12N15/8218 , C12N2310/14 , C12N2310/141 , C12N2310/315 , C12N2310/317 , C12N2310/322 , C12N2310/3231 , C12N2310/344 , C12N2310/346 , C12N2310/351 , C12N2310/53 , C12N2320/32 , C12N2320/51 , C12Y304/21021
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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公开(公告)号：US20170283816A1
公开(公告)日：2017-10-05
申请号：US15617814
申请日：2017-06-08
IPC分类号： C12N15/82 , C12N15/11 , C07H21/02 , C12N15/113
CPC分类号： C12N15/113 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1137 , C12N15/1138 , C12N15/8218 , C12N2310/14 , C12N2310/141 , C12N2310/315 , C12N2310/317 , C12N2310/322 , C12N2310/3231 , C12N2310/344 , C12N2310/346 , C12N2310/351 , C12N2310/53 , C12N2320/32 , C12N2320/51 , C12Y304/21021
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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公开(公告)号：US10351852B2
公开(公告)日：2019-07-16
申请号：US15677719
申请日：2017-08-15
IPC分类号： C07H21/02 , C07H21/04 , C12N15/113 , C12N15/11
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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公开(公告)号：US09732344B2
公开(公告)日：2017-08-15
申请号：US15084865
申请日：2016-03-30
IPC分类号： C07H21/02 , C07H21/04 , C12N15/113
CPC分类号： C12N15/113 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1137 , C12N15/1138 , C12N15/8218 , C12N2310/14 , C12N2310/141 , C12N2310/315 , C12N2310/317 , C12N2310/322 , C12N2310/3231 , C12N2310/344 , C12N2310/346 , C12N2310/351 , C12N2310/53 , C12N2320/32 , C12N2320/51 , C12Y304/21021
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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公开(公告)号：US20160244760A1
公开(公告)日：2016-08-25
申请号：US15084865
申请日：2016-03-30
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1137 , C12N15/1138 , C12N15/8218 , C12N2310/14 , C12N2310/141 , C12N2310/315 , C12N2310/317 , C12N2310/322 , C12N2310/3231 , C12N2310/344 , C12N2310/346 , C12N2310/351 , C12N2310/53 , C12N2320/32 , C12N2320/51 , C12Y304/21021
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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6.发明申请公开(公告)号：US20150105445A1
公开(公告)日：2015-04-16
申请号：US14458578
申请日：2014-08-13
发明人： James McSwiggen , Bharat Chowrira , Leonid Beigelman , Dennis Macejak , Shawn Zinnen , Pamela Pavco , Peter Haeberli , David Morrissey , Kathy Fosnaugh , Sharon F. Jamison , Nassim Usman , James Thompson , Chandra Vargeese , Weimin Wang , Tongqian Chen , Narendra K. Vaish
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K38/00 , A61K47/54 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1138 , C12N15/8218 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/331 , C12N2310/332 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2310/53 , C12N2320/11 , C12N2320/51 , C12N2330/30 , C12N2310/3521 , C12N2310/3533
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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公开(公告)号：US20220275366A1
公开(公告)日：2022-09-01
申请号：US17497747
申请日：2021-10-08
发明人： James McSwiggen , Leonid Beigelman
IPC分类号： C12N15/113 , C12N15/82 , C12N15/11 , C07H21/02 , A61K47/54
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin NA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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8.发明申请公开(公告)号：US20190194658A1
公开(公告)日：2019-06-27
申请号：US16295274
申请日：2019-03-07
IPC分类号： C12N15/113 , C12N15/82 , C12N15/11 , C07H21/02
CPC分类号： C12N15/113 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1137 , C12N15/1138 , C12N15/8218 , C12N2310/14 , C12N2310/141 , C12N2310/315 , C12N2310/317 , C12N2310/322 , C12N2310/3231 , C12N2310/344 , C12N2310/346 , C12N2310/351 , C12N2310/53 , C12N2320/32 , C12N2320/51 , C12Y304/21021
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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公开(公告)号：US09957517B2
公开(公告)日：2018-05-01
申请号：US15617814
申请日：2017-06-08
IPC分类号： C12N15/82 , C12N15/113 , C12N15/11 , C07H21/02
CPC分类号： C12N15/113 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1137 , C12N15/1138 , C12N15/8218 , C12N2310/14 , C12N2310/141 , C12N2310/315 , C12N2310/317 , C12N2310/322 , C12N2310/3231 , C12N2310/344 , C12N2310/346 , C12N2310/351 , C12N2310/53 , C12N2320/32 , C12N2320/51 , C12Y304/21021
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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公开(公告)号：US09771588B2
公开(公告)日：2017-09-26
申请号：US14731346
申请日：2015-06-04
IPC分类号： C07H21/02 , C07H21/04 , C12N15/113 , C12N15/11
CPC分类号： C12N15/1131 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/331 , C12N2310/351 , C12N2310/3515 , C12N2310/533 , C12N2320/11 , C12N2330/30 , C12N2310/3521 , C12N2310/3533
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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