公开(公告)号：US20220349896A1

公开(公告)日：2022-11-03

申请号：US17764096

申请日：2020-09-25

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Richard Heidebrecht ,  Zoe Yin

IPC: G01N33/68 ,  G01N1/40 ,  G01N1/44 ,  C07K19/00 ,  G01N30/86 ,  G01N30/88

Abstract: Described herein are methods for evaluating polymer compositions comprising polymers modified with a polypeptide (e.g., a cell-binding polypeptide), including methods for determining polypeptide concentration.

公开(公告)号：US20230123802A1

公开(公告)日：2023-04-20

申请号：US17598154

申请日：2020-03-27

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Lauren Emily Barney ,  Michael Beauregard ,  Guillaume Carmona ,  Francisco Caballero Gonzalez ,  Richard Heidebrecht ,  Erika Ellen Johnston ,  Robert James Miller ,  Owen O'Connor ,  Matthias Alexander Oberli ,  David Peritt ,  Jared A. Sewell ,  Devyn McKinley Smith ,  Omid Veiseh ,  Paul Kevin Wotton ,  Zoe Yin

IPC: A61K35/30 ,  A61K9/48 ,  C12N9/64 ,  C12N15/52 ,  C12N5/079

Abstract: Described herein are RPE cells engineered to secrete a FVII protein, as well as compositions, pharmaceutical preparations, and implantable devices comprising the engineered RPE cells, and methods of making and using the same for treating a patient with hemophilia or FVII deficiency.

公开(公告)号：US20230003706A1

公开(公告)日：2023-01-05

申请号：US17764101

申请日：2020-09-25

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Richard Heidebrecht ,  Zoe Yin

IPC: G01N33/15 ,  A61K47/61

Abstract: Described herein are methods for evaluating polymer compositions comprising polymers modified with a small molecule compound (e.g., afibrotic compound), including methods for determining the concentration levels of said compounds.

公开(公告)号：US20220267794A1

公开(公告)日：2022-08-25

申请号：US17598176

申请日：2020-03-27

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Lauren Emily Barney ,  Michael Beauregard ,  Guillaume Carmona ,  Francisco Caballero Gonzalez ,  Richard Heidebrecht ,  Erika Ellen Johnston ,  Robert James Miller ,  Owen O'Connor ,  Matthias Alexander Oberli ,  David Peritt ,  Jared A. Sewell ,  Devyn McKinley Smith ,  Omid Veiseh ,  Jeffrey Charles Way ,  Paul Kevin Wotton ,  Zoe Yin ,  Elina Makino ,  Brian Richard Fluharty ,  Marianthi Papakosta

IPC: C12N15/85 ,  A61K38/47 ,  A61K47/22 ,  A61K9/50 ,  C08L5/04

Abstract: Described herein are RPE cells engineered to secrete a GLA protein, as well as compositions, pharmaceutical preparations, and implantable devices comprising the engineered RPE cells, and methods of making and using the same for treating Fabry disease.

公开(公告)号：US20220000789A1

公开(公告)日：2022-01-06

申请号：US17280802

申请日：2019-09-27

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Lauren Emily Barney ,  Michael Beauregard ,  Guillaume Carmona ,  Francisco Caballero Gonzalez ,  Richard Heidebrecht ,  Erika Ellen Johnston ,  Robert James Miller ,  Owen O'Connor ,  Matthias Alexander Oberli ,  David Peritt ,  Jared A. Sewell ,  Devyn McKinley Smith ,  Omid Veiseh ,  Paul Kevin Wotton ,  Zoe Yin

IPC: A61K9/50 ,  A61K35/30 ,  A61K38/37

Abstract: Described herein are implantable devices comprising means for mitigating the foreign body response (FBR) and at least one cell-containing compartment which comprises a plurality of cells (e.g., live cells) encapsulated in a polymer composition comprising a cell-binding substance (CBS), as well as compositions and methods of making and using the same. The cells are capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.