公开(公告)号：US20220267794A1

公开(公告)日：2022-08-25

申请号：US17598176

申请日：2020-03-27

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Lauren Emily Barney ,  Michael Beauregard ,  Guillaume Carmona ,  Francisco Caballero Gonzalez ,  Richard Heidebrecht ,  Erika Ellen Johnston ,  Robert James Miller ,  Owen O'Connor ,  Matthias Alexander Oberli ,  David Peritt ,  Jared A. Sewell ,  Devyn McKinley Smith ,  Omid Veiseh ,  Jeffrey Charles Way ,  Paul Kevin Wotton ,  Zoe Yin ,  Elina Makino ,  Brian Richard Fluharty ,  Marianthi Papakosta

IPC: C12N15/85 ,  A61K38/47 ,  A61K47/22 ,  A61K9/50 ,  C08L5/04

Abstract: Described herein are RPE cells engineered to secrete a GLA protein, as well as compositions, pharmaceutical preparations, and implantable devices comprising the engineered RPE cells, and methods of making and using the same for treating Fabry disease.