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公开(公告)号：US20220349896A1
公开(公告)日：2022-11-03
申请号：US17764096
申请日：2020-09-25
Applicant: SIGILON THERAPEUTICS, INC.
Inventor： Richard Heidebrecht , Zoe Yin
Abstract: Described herein are methods for evaluating polymer compositions comprising polymers modified with a polypeptide (e.g., a cell-binding polypeptide), including methods for determining polypeptide concentration.
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公开(公告)号：US20210145759A1
公开(公告)日：2021-05-20
申请号：US17045127
申请日：2019-03-27
Applicant: SIGILON THERAPEUTICS, INC.
Inventor： Lauren Emily Barney , Michael Beauregard , Guillaume Carmona , Francisco Caballero Gonzalez , Richard Heidebrecht , Erika Ellen Johnston , Robert James Miller , Matthias Alexander Oberli , Owen O'Connor , David Peritt , Jared A. Sewell , Devyn McKinley Smith , Omid Veiseh , Paul Kevin Wotton
Abstract: Described herein are particles comprising a first compartment, a second compartment, and a compound of Formula (I), as well as compositions and methods of making and using the same. The particles may comprise a cell capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.
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公开(公告)号：US20200263196A1
公开(公告)日：2020-08-20
申请号：US16651892
申请日：2018-09-27
Applicant: SIGILON THERAPEUTICS, INC.
Inventor： Guillaume Carmona , Francisco Caballero Gonzalez , Richard Heidebrecht , Robert James Miller , Matthias Alexander Oberli , David Peritt , Jared A. Sewell , Devyn McKinley Smith , Omid Veiseh , Paul Kevin Wotton
IPC: C12N15/85 , C12N5/079 , A61K35/30 , C07K14/755 , C07K14/55 , C07K14/635 , A61K9/00 , A61K9/48 , A61K47/54
Abstract: Described herein are cell compositions comprising an active cell (e.g., an engineered active cell, e.g., an engineered RPE cell) or derivatives thereof, as well as compositions, pharmaceutical products, and implantable elements comprising an active cell, and methods of making and using the same. The cells and compositions may express a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.
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公开(公告)号：US20250017864A1
公开(公告)日：2025-01-16
申请号：US18705759
申请日：2022-10-28
Applicant: SIGILON THERAPEUTICS, INC.
Inventor： Lauren Emily Barney , Hozefa Bandukwala , Susan J. Drapeau , Lauren E. Jansen
Abstract: Described herein are hydrogel capsule compositions which comprise a population of hydrogel capsules and a pharmaceutically acceptable solution. The hydrogel capsules in the population comprise a hydrogel-forming polymer and encapsulate a plurality of cells.
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公开(公告)号：US20250000788A1
公开(公告)日：2025-01-02
申请号：US18274134
申请日：2022-01-26
Applicant: SIGILON THERAPEUTICS, INC.
Inventor： Sofia Brites Boss , Christopher P. Hencken , Hozefa Bandukwala , Robert James Miller , Omid Veiseh , Devyn McKinley Smith
IPC: A61K9/00 , A61K9/50 , A61K31/5685 , A61K31/573 , A61K31/58 , A61K35/545 , A61K38/13 , A61K38/17 , A61K38/20 , A61K47/61 , A61K47/69
Abstract: Described herein are implantable devices comprising living cells and an extended release formulation of a glucocorticoid.
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Patent Agency Ranking
公开(公告)号：US20230303502A1
公开(公告)日：2023-09-28
申请号：US18019664
申请日：2021-08-04
Applicant: SIGILON THERAPEUTICS, INC.
Inventor： Richard Heidebrecht , Christopher P. Hencken , Omar De Paolis , Weiheng Wang , Matthew Buchanan
IPC: C07D249/04 , C07D471/04 , C07D487/04 , C07D401/12 , C07D403/12 , C07D403/14
CPC classification number: C07D249/04 , C07D471/04 , C07D487/04 , C07D401/12 , C07D403/12 , C07D403/14
Abstract: Described herein are compounds of Formulas (I), (II), and (III) and pharmaceutically acceptable salts thereof, related compositions and preparations thereof, as well as methods of making and using the same.
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公开(公告)号：US20210145889A1
公开(公告)日：2021-05-20
申请号：US17045137
申请日：2019-03-27
Applicant: SIGILON THERAPEUTICS, INC.
Inventor： Devyn McKinley Smith , David Peritt , Omid Veiseh , Richard Heidebrecht , Robert James Miller
IPC: A61K35/28 , A61K9/00 , A61K47/22 , A61K9/50 , A61L27/38 , A61K38/37 , A61K38/48 , C12N5/00 , A61K38/28 , C12N5/0775
Abstract: Described herein are cell compositions comprising a mesenchymal stem function cell (MSFC), e.g., an engineered MSFC or derivatives thereof, as well as compositions, pharmaceutical products, and implantable elements comprising an MSFC, and methods of making and using the same. The cells and compositions may express a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.
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公开(公告)号：US20250066512A1
公开(公告)日：2025-02-27
申请号：US18724811
申请日：2022-12-30
Applicant: SIGILON THERAPEUTICS, INC.
Inventor： Matthew Buchanan , Omar De Paolis , Weiheng Wang , Christopher P. Hencken
Abstract: Described herein are polysaccharide polymers comprising a saccharide moiety modified with a hydroxyl-modifying agent (e.g., a saccharide monomer of Formula (I)), as well as related compositions, hydrogels, implantable elements, and methods of use thereof.
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公开(公告)号：US12162994B2
公开(公告)日：2024-12-10
申请号：US16977735
申请日：2019-03-01
Applicant: SIGILON THERAPEUTICS, INC.
Abstract: Described herein are compositions and methods for preparing hydrogel capsules using a cross-linking solution comprising a process additive. The process additive improves the quality of the resulting hydrogel capsules, such as increasing the number of defect-free capsules.
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公开(公告)号：US12161760B2
公开(公告)日：2024-12-10
申请号：US17045127
申请日：2019-03-27
Applicant: SIGILON THERAPEUTICS, INC.
Inventor： Lauren Emily Barney , Michael Beauregard , Guillaume Carmona , Francisco Caballero Gonzalez , Richard Heidebrecht , Erika Ellen Johnston , Robert James Miller , Matthias Alexander Oberli , Owen O'Connor , David Peritt , Jared A. Sewell , Devyn McKinley Smith , Omid Veiseh , Paul Kevin Wotton
Abstract: Described herein are particles comprising a first compartment, a second compartment, and a compound of Formula (I), as well as compositions and methods of making and using the same. The particles may comprise a cell capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.
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