公开(公告)号：US20230330302A1

公开(公告)日：2023-10-19

申请号：US18044684

申请日：2021-07-30

Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES

Inventor： Yuxiao LAI ,  Yuanyi SUN

IPC: A61L27/44 ,  A61L27/58 ,  A61L27/56 ,  A61L27/02 ,  A61F2/30

CPC classification number: A61L27/446 ,  A61L27/58 ,  A61L27/56 ,  A61L27/025 ,  A61F2/3094 ,  A61L2430/02 ,  A61L2400/12 ,  A61F2002/30985 ,  A61F2310/00065

Abstract: Provided are an orthopedic repair scaffold, a preparation method thereof and use thereof. The orthopedic repair scaffold is a three-dimensional porous scaffold. A material of the orthopedic repair scaffold comprises the following components in mass percentage: 80%-95% of a biodegradable polymer and 5%-20% of a biodegradable nanoparticle, where the biodegradable nanoparticle is a nanoparticle of manganese compound. The preparation method of the orthopedic repair scaffold comprises: preparing a homogeneous solution comprising a biodegradable polymer and a biodegradable nanoparticle according to the mass percentage; preparing the homogeneous solution through a curing molding process into a molded three-dimensional porous scaffold; and freeze-drying the molded three-dimensional porous scaffold to obtain the orthopedic repair scaffold. The orthopedic repair scaffold can better promote healing of a bone injury and has an excellent mechanical performance and a good medical imaging function.

公开(公告)号：US20240293310A1

公开(公告)日：2024-09-05

申请号：US18044683

申请日：2021-12-15

Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES

Inventor： Yuxiao LAI ,  Wenjing ZHANG ,  Wei ZHANG ,  Cairong LI ,  Zhenyu YAO

IPC: A61K9/06 ,  A61K9/00 ,  A61K38/44 ,  A61K47/02 ,  A61P19/08

CPC classification number: A61K9/06 ,  A61K9/0019 ,  A61K38/44 ,  A61K47/02 ,  A61P19/08

Abstract: Disclosed is a metal peroxide composite injectable hydrogel, a preparation method and use thereof. The preparation method comprises the step of dissolving a modified high-molecular polymer, a metal peroxide and a peroxidase in a solvent, mixing evenly, and standing to prepare the hydrogel, wherein the modified high-molecular polymer is a high-molecular polymer grafted with a phenolic hydroxyl group. According to the invention, the metal peroxide induces the modified high-molecular polymer to be quickly crosslinked under an action of the peroxidase to prepare the hydrogel, and the prepared hydrogel has good photo-thermal performance, antibacterial property, tissue adhesion, osteogenesis promoting effect, shape adaptability and injectability, can be well adapted to an irregular bone defect area, and is used for repairing a postoperative defect of tumor through a synergistic effect of multiple functions, which can effectively prevent tumor recurrence and reduce a possibility of implant material infection.