公开(公告)号：US20240293310A1

公开(公告)日：2024-09-05

申请号：US18044683

申请日：2021-12-15

Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES

Inventor： Yuxiao LAI ,  Wenjing ZHANG ,  Wei ZHANG ,  Cairong LI ,  Zhenyu YAO

IPC: A61K9/06 ,  A61K9/00 ,  A61K38/44 ,  A61K47/02 ,  A61P19/08

CPC classification number: A61K9/06 ,  A61K9/0019 ,  A61K38/44 ,  A61K47/02 ,  A61P19/08

Abstract: Disclosed is a metal peroxide composite injectable hydrogel, a preparation method and use thereof. The preparation method comprises the step of dissolving a modified high-molecular polymer, a metal peroxide and a peroxidase in a solvent, mixing evenly, and standing to prepare the hydrogel, wherein the modified high-molecular polymer is a high-molecular polymer grafted with a phenolic hydroxyl group. According to the invention, the metal peroxide induces the modified high-molecular polymer to be quickly crosslinked under an action of the peroxidase to prepare the hydrogel, and the prepared hydrogel has good photo-thermal performance, antibacterial property, tissue adhesion, osteogenesis promoting effect, shape adaptability and injectability, can be well adapted to an irregular bone defect area, and is used for repairing a postoperative defect of tumor through a synergistic effect of multiple functions, which can effectively prevent tumor recurrence and reduce a possibility of implant material infection.