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公开(公告)号：US09732084B2
公开(公告)日：2017-08-15
申请号：US14072904
申请日：2013-11-06
发明人： Philip Wilson Howard , Luke Masterson , Arnaud Tiberghien , Scott Jeffrey , Patrick Burke , Peter Senter
IPC分类号： C07D487/04 , C07D519/00 , A61K47/48
CPC分类号： C07D487/04 , A61K47/6803 , A61K47/6849 , A61K47/6851 , C07D519/00
摘要： Pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position on one monomer unit, and a C2-C3 double bond and either a conjugated double or triple bond at the C2 position or an alkyl group at the C2 position on the other monomer unit, and conjugates of these compounds.
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公开(公告)号：US10561739B2
公开(公告)日：2020-02-18
申请号：US16381448
申请日：2019-04-11
IPC分类号： C07D487/04 , C07D519/00 , A61K47/68 , C07K16/30 , C07K16/28 , A61K31/5517 , A61K39/00
摘要： Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs.
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公开(公告)号：US20180228916A1
公开(公告)日：2018-08-16
申请号：US15951753
申请日：2018-04-12
CPC分类号： A61K47/6851 , A61K31/5517 , A61K47/6803 , A61K47/6849 , A61K47/6861 , A61K47/6867 , A61K47/6871 , A61K47/6889 , A61K2039/505 , C07K16/2812 , C07K16/2875 , C07K16/2878 , C07K16/30 , C07K16/3038 , C07K16/3061 , C07K2317/21 , C07K2317/24 , Y02A50/385 , Y02A50/414 , Y02A50/423
摘要： Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs.
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公开(公告)号：US20190336614A1
公开(公告)日：2019-11-07
申请号：US16381448
申请日：2019-04-11
IPC分类号： A61K47/68 , C07K16/30 , C07K16/28 , A61K31/5517
摘要： Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs.
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公开(公告)号：US09592240B2
公开(公告)日：2017-03-14
申请号：US14995944
申请日：2016-01-14
IPC分类号： C07D519/00 , C07D487/04 , A61K31/5517 , A61K47/48 , C07K16/28 , C07K16/30 , A61K39/00
CPC分类号： A61K47/6851 , A61K31/5517 , A61K47/6803 , A61K47/6849 , A61K47/6861 , A61K47/6867 , A61K47/6871 , A61K47/6889 , A61K2039/505 , C07K16/2812 , C07K16/2875 , C07K16/2878 , C07K16/30 , C07K16/3038 , C07K16/3061 , C07K2317/21 , C07K2317/24 , Y02A50/385 , Y02A50/414 , Y02A50/423
摘要： Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs.
摘要翻译： 提供了包含与靶向剂缀合的PBD的缀合物和使用这种PBD的方法。
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6.发明申请公开(公告)号：US20180353524A1
公开(公告)日：2018-12-13
申请号：US15781256
申请日：2016-12-02
发明人： Shyra Gardai , Che-Leung Law , Peter Senter , Nicole Okeley , Jessica Field
IPC分类号： A61K31/70 , A61K39/395 , A61P35/00
CPC分类号： A61K31/70 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61P35/00 , C07K16/2818 , A61K2300/00
摘要： The present invention is directed to methods for treating cancer comprising administering to a subject in need thereof an effective amount of 2-deoxy-2-fluoro-L-fucose or a prodrug thereof, or a pharmaceutically acceptable salt thereof, in combination with a checkpoint inhibitor.
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公开(公告)号：US20170216391A1
公开(公告)日：2017-08-03
申请号：US15118031
申请日：2015-02-17
发明人： Svetlana Doronina , Robert Lyon , Peter Senter
CPC分类号： A61K38/05 , A61K9/0019 , A61K47/6803 , A61K47/6861 , A61K47/6867 , A61K47/6889
摘要： Hydrophilic Linkers, Drug-Linker compounds, Drug-Ligand Conjugate compounds and Ligand-Linkers and methods of making and using the same are provided.
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公开(公告)号：US20140050746A1
公开(公告)日：2014-02-20
申请号：US14061261
申请日：2013-10-23
发明人： Peter Senter , Svetlana Doronina , Timothy Bovee
CPC分类号： A61K47/48723 , A61K38/00 , A61K38/08 , A61K45/06 , A61K47/65 , A61K47/6811 , A61K47/6849 , A61K47/6861 , A61K47/6865 , A61K47/6867 , C07K5/0205 , G01N33/5008 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/423 , Y02A50/471 , Y02A50/475 , Y02A50/483 , Y02A50/492
摘要： Drug Linker compounds and Drug Linker Ligand conjugates are provided that have auristatins linked via the C-terminus. The conjugates show efficacy without the need for a self-immolative group to release the drug.
摘要翻译： 提供了通过C-末端连接耳垢的药物连接子化合物和药物连接子配体缀合物。 缀合物显示出有效性，而不需要自焚组来释放药物。
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公开(公告)号：US10342811B2
公开(公告)日：2019-07-09
申请号：US15299894
申请日：2016-10-21
发明人： Peter Senter , Stephen Alley , Dennis Benjamin
IPC分类号： A61K9/00 , A61K39/00 , A61K45/06 , C07K16/00 , C07K16/18 , A61K31/7004 , A61K31/7024 , A61K31/7042 , A61K31/706 , A61K31/7048
摘要： The invention provides methods and compositions for the inhibition of fucosylation of proteins, including antibodies, in vivo by administration of a fucose analog.
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公开(公告)号：US09463252B2
公开(公告)日：2016-10-11
申请号：US14061261
申请日：2013-10-23
发明人： Peter Senter , Svetlana Doronina , Timothy Bovee
CPC分类号： A61K47/48723 , A61K38/00 , A61K38/08 , A61K45/06 , A61K47/65 , A61K47/6811 , A61K47/6849 , A61K47/6861 , A61K47/6865 , A61K47/6867 , C07K5/0205 , G01N33/5008 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/423 , Y02A50/471 , Y02A50/475 , Y02A50/483 , Y02A50/492
摘要： Drug Linker compounds and Drug Linker Ligand conjugates are provided that have auristatins linked via the C-terminus. The conjugates show efficacy without the need for a self-immolative group to release the drug.
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