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公开(公告)号：US07608723B2
公开(公告)日：2009-10-27
申请号：US11251440
申请日：2005-10-14
申请人： Rustum S. Boyce , Yi Xia , Hongyan Guo , Kris G. Mendenhull , Annette O. Walter , Weibo Wang
发明人： Rustum S. Boyce , Yi Xia , Hongyan Guo , Kris G. Mendenhull , Annette O. Walter , Weibo Wang
IPC分类号： C07D209/10 , C07D235/14 , A61K31/33
CPC分类号： C07D403/12 , C07D209/14 , C07D235/14 , C07D401/12 , C07D403/04 , C07D403/14
摘要： The present invention relates to new indole and benzimidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译： 本发明涉及新的吲哚和苯并咪唑化合物及其药学上可接受的盐，酯或前药，新化合物的组合物和药学上可接受的载体，以及新化合物的用途。 本发明的化合物具有以下通式：
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公开(公告)号：US08008335B2
公开(公告)日：2011-08-30
申请号：US11665956
申请日：2005-10-14
申请人： Rustum S. Boyce , Yi Xia , Hongyan Guo , Kris G. Mendenhall , Annette O. Walter , Weibo Wang
发明人： Rustum S. Boyce , Yi Xia , Hongyan Guo , Kris G. Mendenhall , Annette O. Walter , Weibo Wang
IPC分类号： A61K31/4045 , A61K31/417 , C07D209/14 , C07D235/14
CPC分类号： C07D403/12 , C07D209/14 , C07D235/14 , C07D401/12 , C07D403/04 , C07D403/14
摘要： The present invention relates to new indole and benzimidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula (I).
摘要翻译： 本发明涉及新的吲哚和苯并咪唑化合物及其药学上可接受的盐，酯或前药，新化合物的组合物和药学上可接受的载体，以及新化合物的用途。 本发明的化合物具有以下通式（I）。
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公开(公告)号：US20080317744A1
公开(公告)日：2008-12-25
申请号：US11665956
申请日：2005-10-14
申请人： Rustum S. Boyce , Yi Xia , Hongyan Guo , Kris G. Mendenhall , Annette O. Walter , Weibo Wang
发明人： Rustum S. Boyce , Yi Xia , Hongyan Guo , Kris G. Mendenhall , Annette O. Walter , Weibo Wang
IPC分类号： C07D401/12 , C07D209/14 , C07D403/12 , C07D235/04 , A61K31/4184 , A61K31/404 , A61K35/00 , A61K39/395
CPC分类号： C07D403/12 , C07D209/14 , C07D235/14 , C07D401/12 , C07D403/04 , C07D403/14
摘要： The present invention relates to new indole and benzimidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译： 本发明涉及新的吲哚和苯并咪唑化合物及其药学上可接受的盐，酯或前药，新化合物的组合物和药学上可接受的载体，以及新化合物的用途。 本发明的化合物具有以下通式：
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公开(公告)号：US20060084687A1
公开(公告)日：2006-04-20
申请号：US11251440
申请日：2005-10-14
申请人： Rustum Boyce , Hongyan Guo , Kris Mendenhall , Annette Walter , Weibo Wang , Yia Xia
发明人： Rustum Boyce , Hongyan Guo , Kris Mendenhall , Annette Walter , Weibo Wang , Yia Xia
IPC分类号： A61K31/433 , A61K31/427 , A61K31/422 , A61K31/42 , A61K31/4184 , A61K31/416 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D403/12 , C07D209/14 , C07D235/14 , C07D401/12 , C07D403/04 , C07D403/14
摘要： The present invention relates to new indole and benzimidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
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公开(公告)号：US09296758B2
公开(公告)日：2016-03-29
申请号：US13806048
申请日：2011-07-01
申请人： Kerim Babaoglu , Kyla Bjornson , Hongyan Guo , Randall L. Halcomb , John O. Link , Hongtao Liu , Michael L. Mitchell , Jianyu Sun , James Taylor , Randall W. Vivian , Lianhong Xu
发明人： Kerim Babaoglu , Kyla Bjornson , Hongyan Guo , Randall L. Halcomb , John O. Link , Hongtao Liu , Michael L. Mitchell , Jianyu Sun , James Taylor , Randall W. Vivian , Lianhong Xu
IPC分类号： C07D498/04 , C07D215/06 , C07D215/14 , C07D215/18 , C07D215/227 , C07D215/38 , C07D215/48 , C07D401/04 , C07D401/12 , C07D405/04 , C07D413/04 , C07D417/04 , C07D487/04 , C07D519/00 , C07D491/052 , C07D215/20
CPC分类号： C07D498/04 , C07D215/06 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/227 , C07D215/38 , C07D215/48 , C07D401/04 , C07D401/12 , C07D405/04 , C07D413/04 , C07D417/04 , C07D487/04 , C07D491/052 , C07D519/00
摘要： The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I).
摘要翻译： 本发明提供了本文所述的式（I）化合物或其盐。 本发明还提供包含式（I）化合物的药物组合物，制备式（I）化合物的方法，用于制备式I化合物的中间体和治疗HIV病毒增殖的治疗方法，治疗AIDS或延迟 使用式（I）化合物在哺乳动物中发生AIDS或ARC症状。
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公开(公告)号：US08334295B2
公开(公告)日：2012-12-18
申请号：US12215450
申请日：2008-06-26
申请人： Hongyan Guo , Choung U. Kim , Ill Y. Lee , Michael L. Mitchell , Gerry Rhodes , Jong C. Son , Lianhong Xu
发明人： Hongyan Guo , Choung U. Kim , Ill Y. Lee , Michael L. Mitchell , Gerry Rhodes , Jong C. Son , Lianhong Xu
IPC分类号： A61K31/505
CPC分类号： A61K31/513 , A61K31/496 , A61K31/536 , A61K31/551 , A61K31/66 , A61K31/7048 , A61K31/7072 , A61K31/708 , A61K39/39558 , A61K45/06 , C07D239/54 , C07D239/545 , C07D239/553 , C07D239/60 , C07D401/04 , C07D403/04
摘要： The invention is related to compounds of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，酯和/或膦酸盐，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法。
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公开(公告)号：US20120157404A1
公开(公告)日：2012-06-21
申请号：US13291977
申请日：2011-11-08
申请人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard L. Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
发明人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard L. Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
IPC分类号： A61K31/4184 , A61K31/501 , A61K31/439 , A61K31/7056 , A61K31/7068 , A61K31/496 , A61P31/14
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US08669234B2
公开(公告)日：2014-03-11
申请号：US13491446
申请日：2012-06-07
申请人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Evan S. Krygowski , John O. Link , Michael L. Mitchell , Jay P. Parrish , James Taylor
发明人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Evan S. Krygowski , John O. Link , Michael L. Mitchell , Jay P. Parrish , James Taylor
IPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D495/04 , A61P1/16 , A61P31/14 , A61K31/4178 , A61K31/7068 , A61K31/7052 , A61K31/4184 , A61K31/7056
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20130203727A1
公开(公告)日：2013-08-08
申请号：US13806067
申请日：2011-07-01
申请人： Kerim Babaoglu , Elizabeth Bacon , Kyla Bjornson , Hongyan Guo , Randall L. Halcomb , Paul Hrvatin , John O. Link , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Paul Roethle , James Taylor , James D. Trenkle , Randall W. Vivian , Lianhong Xu
发明人： Kerim Babaoglu , Elizabeth Bacon , Kyla Bjornson , Hongyan Guo , Randall L. Halcomb , Paul Hrvatin , John O. Link , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Paul Roethle , James Taylor , James D. Trenkle , Randall W. Vivian , Lianhong Xu
IPC分类号： C07C59/64 , C07D491/06 , C07D205/04 , C07D239/34 , C07D295/155 , C07C311/16 , C07C255/57 , C07C229/34 , C07D213/65 , C07D239/26 , C07D231/12 , C07D487/04 , C07D211/48 , C07D309/10 , C07D311/58 , C07C233/47 , C07C271/22 , C07D239/42 , C07D239/36 , C07D215/14
CPC分类号： C07C59/64 , C07C229/34 , C07C233/47 , C07C255/57 , C07C271/22 , C07C311/16 , C07D205/04 , C07D211/48 , C07D213/64 , C07D213/65 , C07D213/73 , C07D215/04 , C07D215/14 , C07D231/12 , C07D233/58 , C07D239/26 , C07D239/34 , C07D239/36 , C07D239/42 , C07D241/12 , C07D295/073 , C07D295/155 , C07D309/10 , C07D311/20 , C07D311/58 , C07D487/04 , C07D491/06 , C07D493/04
摘要： The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I).
摘要翻译： 本发明提供了本文所述的式（I）化合物或其盐。 本发明还提供了包含式I化合物的药物组合物，制备式（I）化合物的方法，用于制备式I化合物的中间体和治疗HIV病毒增殖的治疗方法，治疗AIDS或延迟 使用式（I）化合物的哺乳动物中的AIDS或ARC症状。
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公开(公告)号：US08273341B2
公开(公告)日：2012-09-25
申请号：US13291977
申请日：2011-11-08
申请人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Michael Graupe , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard Mackman , Hyung-Jun Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
发明人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Michael Graupe , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard Mackman , Hyung-Jun Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
IPC分类号： A61K31/4178 , A61K31/435 , A61K31/55 , A61K31/438 , A61K31/496 , A61K31/5415 , A61K31/708 , A61K31/7052 , A61K38/21 , C07D403/14 , C07D401/14 , C07D417/14 , A61P31/14
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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