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    Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres
    2.
    发明授权
    Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres 失效
    使用磁性微球的生物测定和生物分子鉴定，分选和收集方法

    公开(公告)号：US07232691B2

    公开(公告)日：2007-06-19

    申请号：US09995304

    申请日：2001-11-27

    申请人： Robert H. Kraus, Jr. ,  Feng Zhou ,  John P Nolan

    发明人： Robert H. Kraus, Jr. ,  Feng Zhou ,  John P Nolan

    IPC分类号： G01N33/553 ,  C12Q1/00

    CPC分类号： G01N27/745 ,  B03C1/00 ,  G01N33/54326 ,  G01N2015/0288 ,  Y10T436/115831 ,  Y10T436/12

    摘要： The present invention is directed to processes of separating, analyzing and/or collecting selected species within a target sample by use of magnetic microspheres including magnetic particles, the magnetic microspheres adapted for attachment to a receptor agent that can subsequently bind to selected species within the target sample. The magnetic microspheres can be sorted into a number of distinct populations, each population with a specific range of magnetic moments and different receptor agents can be attached to each distinct population of magnetic microsphere.

    摘要翻译： 本发明涉及通过使用包括磁性颗粒的磁性微球分离，分析和/或收集目标样品内的选定物质的方法，所述磁性微球体适于附着于可以随后与目标物中选定物种结合的受体剂 样品。 磁性微球可以分为多个不同的群体，具有特定范围的磁矩的每个群体和不同的受体剂可以连接到每个不同的磁性微球体。

    Direct imaging of neural currents using ultra-low field magnetic resonance techniques
    6.
    发明授权
    Direct imaging of neural currents using ultra-low field magnetic resonance techniques 有权
    使用超低场磁共振技术直接成像神经电流

    公开(公告)号：US07573268B2

    公开(公告)日：2009-08-11

    申请号：US11678023

    申请日：2007-02-22

    申请人： Petr L. Volegov ,  Andrei N. Matlashov ,  John C. Mosher ,  Michelle A. Espy ,  Robert H. Kraus, Jr.

    发明人： Petr L. Volegov ,  Andrei N. Matlashov ,  John C. Mosher ,  Michelle A. Espy ,  Robert H. Kraus, Jr.

    IPC分类号： G01V3/00

    CPC分类号： A61B5/055

    摘要： Using resonant interactions to directly and tomographically image neural activity in the human brain using magnetic resonance imaging (MRI) techniques at ultra-low field (ULF), the present inventors have established an approach that is sensitive to magnetic field distributions local to the spin population in cortex at the Larmor frequency of the measurement field. Because the Larmor frequency can be readily manipulated (through varying Bm), one can also envision using ULF-DNI to image the frequency distribution of the local fields in cortex. Such information, taken together with simultaneous acquisition of MEG and ULF-NMR signals, enables non-invasive exploration of the correlation between local fields induced by neural activity in cortex and more ‘distant’ measures of brain activity such as MEG and EEG.

    摘要翻译： 本发明人利用超低场（ULF）中的磁共振成像（MRI）技术直接使用共振相互作用和层析成像对人脑中的神经活动图像，建立了对旋转群体局部的磁场分布敏感的方法 在皮质中的拉莫尔频率测量领域。 因为Larmor频率可以容易地被操纵（通过变化的Bm），也可以设想使用ULF-DNI对皮层中的局部场的频率分布进行成像。 这些信息与MEG和ULF-NMR信号的同时采集一起使得能够非侵入性地探索由皮层神经活动引起的局部区域与脑活动（例如MEG和EEG）的更远的“测量”之间的相关性。