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    Fluorination of acrylate esters and derivatives
    2.
    发明授权
    Fluorination of acrylate esters and derivatives 有权

    公开(公告)号：US10138198B2

    公开(公告)日：2018-11-27

    申请号：US15680325

    申请日：2017-08-18

    Applicant: Relypsa, Inc.

    Inventor： YongQi Mu

    IPC: C07C51/62 ,  C07C51/363 ,  C07C53/21 ,  C07C53/50 ,  C07C67/307 ,  C07C69/63 ,  C07C253/30 ,  C07C255/03 ,  C07C51/36 ,  C07C67/22 ,  C07C253/32 ,  C07C51/50 ,  C07C51/64 ,  C07C67/03 ,  C07C67/62

    Abstract: The present disclosure generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent. In particular, a continuous process for fluorinating a double bond is disclosed, the process comprising forming a reaction stream comprising a compound of formula 1 or formula 5 dissolved in a hydrofluorocarbon or fluorocarbon solvent, wherein R1 is hydroxy, alkoxy, chloro, or —OC(O)CH═CH2; the reaction stream flowing through a continuous fluorination reactor at a flow rate of from about 0.2 mL/minute to about 2 mL/minute and fluorine gas flows through the continuous fluorination reactor at a gas flow rate of from about 0.2 mmol/minute to about 2 mmol/minute; whereby reaction of the compound of formula 1 or formula 5 with the fluorine gas forms a compound of formula 2 or formula 6 wherein R2 is hydroxy, alkoxy, chloro, or —OC(O)CHFCH2F.

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