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公开(公告)号:US20150284319A1
公开(公告)日:2015-10-08
申请号:US14742381
申请日:2015-06-17
Applicant: Relypsa, Inc.
Inventor: YongQi Mu
IPC: C07C253/30 , C07C67/22 , C07C253/32
CPC classification number: C07C51/36 , C07C51/363 , C07C51/50 , C07C51/62 , C07C51/64 , C07C67/03 , C07C67/22 , C07C67/307 , C07C67/62 , C07C253/30 , C07C253/32 , C07C69/63 , C07C53/21 , C07C53/50 , C07C255/03
Abstract: The present invention generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent.
Abstract translation: 本发明一般涉及将丙烯酸酯或其衍生物转化为二氟丙酸或其衍生物的方法。 该方法通常在氢氟烃溶剂中使用氟气进行。
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公开(公告)号:US10138198B2
公开(公告)日:2018-11-27
申请号:US15680325
申请日:2017-08-18
Applicant: Relypsa, Inc.
Inventor: YongQi Mu
IPC: C07C51/62 , C07C51/363 , C07C53/21 , C07C53/50 , C07C67/307 , C07C69/63 , C07C253/30 , C07C255/03 , C07C51/36 , C07C67/22 , C07C253/32 , C07C51/50 , C07C51/64 , C07C67/03 , C07C67/62
Abstract: The present disclosure generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent. In particular, a continuous process for fluorinating a double bond is disclosed, the process comprising forming a reaction stream comprising a compound of formula 1 or formula 5 dissolved in a hydrofluorocarbon or fluorocarbon solvent, wherein R1 is hydroxy, alkoxy, chloro, or —OC(O)CH═CH2; the reaction stream flowing through a continuous fluorination reactor at a flow rate of from about 0.2 mL/minute to about 2 mL/minute and fluorine gas flows through the continuous fluorination reactor at a gas flow rate of from about 0.2 mmol/minute to about 2 mmol/minute; whereby reaction of the compound of formula 1 or formula 5 with the fluorine gas forms a compound of formula 2 or formula 6 wherein R2 is hydroxy, alkoxy, chloro, or —OC(O)CHFCH2F.
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3.
公开(公告)号:US10272103B2
公开(公告)日:2019-04-30
申请号:US14928517
申请日:2015-10-30
Applicant: Relypsa, Inc.
Inventor: Jordan Kopping , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace May , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter
IPC: A61K31/785 , C08F226/02 , A61K45/06 , C08F222/38 , C08F20/52 , C08F22/38 , C08F232/08
Abstract: The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
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公开(公告)号:US09738584B2
公开(公告)日:2017-08-22
申请号:US15287105
申请日:2016-10-06
Applicant: Relypsa, Inc.
Inventor: YongQi Mu
IPC: C07C51/36 , C07C51/363 , C07C51/62 , C07C67/307 , C07C67/22 , C07C253/30 , C07C253/32 , C07C51/50 , C07C51/64 , C07C67/03 , C07C67/62
CPC classification number: C07C51/36 , C07C51/363 , C07C51/50 , C07C51/62 , C07C51/64 , C07C67/03 , C07C67/22 , C07C67/307 , C07C67/62 , C07C253/30 , C07C253/32 , C07C69/63 , C07C53/21 , C07C53/50 , C07C255/03
Abstract: The present invention generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent.
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5.
公开(公告)号:US20160051576A1
公开(公告)日:2016-02-25
申请号:US14928517
申请日:2015-10-30
Applicant: Relypsa, Inc.
Inventor: Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Huynh , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
IPC: A61K31/785 , C08F226/02 , A61K45/06 , C08F222/38
CPC classification number: A61K31/785 , A61K45/06 , C08F20/52 , C08F22/385 , C08F222/385 , C08F226/02 , C08F232/08
Abstract: The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
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公开(公告)号:US20180099918A1
公开(公告)日:2018-04-12
申请号:US15680325
申请日:2017-08-18
Applicant: Relypsa, Inc.
Inventor: YongQi Mu
IPC: C07C51/36 , C07C51/50 , C07C67/62 , C07C67/22 , C07C51/64 , C07C51/62 , C07C253/32 , C07C253/30 , C07C67/03 , C07C51/363 , C07C67/307 , C07C69/63 , C07C53/21 , C07C53/50 , C07C255/03
CPC classification number: C07C51/36 , C07C51/363 , C07C51/50 , C07C51/62 , C07C51/64 , C07C67/03 , C07C67/22 , C07C67/307 , C07C67/62 , C07C253/30 , C07C253/32 , C07C69/63 , C07C53/21 , C07C53/50 , C07C255/03
Abstract: The present invention generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent.
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公开(公告)号:US20170036985A1
公开(公告)日:2017-02-09
申请号:US15287105
申请日:2016-10-06
Applicant: Relypsa, Inc.
Inventor: YongQi Mu
IPC: C07C51/36 , C07C51/62 , C07C253/30 , C07C67/03 , C07C51/64 , C07C67/62 , C07C51/50 , C07C67/307 , C07C253/32
CPC classification number: C07C51/36 , C07C51/363 , C07C51/50 , C07C51/62 , C07C51/64 , C07C67/03 , C07C67/22 , C07C67/307 , C07C67/62 , C07C253/30 , C07C253/32 , C07C69/63 , C07C53/21 , C07C53/50 , C07C255/03
Abstract: The present invention generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent.
Abstract translation: 本发明一般涉及将丙烯酸酯或其衍生物转化为二氟丙酸或其衍生物的方法。 该方法通常在氢氟烃溶剂中使用氟气进行。
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公开(公告)号:US20170258825A1
公开(公告)日:2017-09-14
申请号:US15601291
申请日:2017-05-22
Applicant: Relypsa, Inc.
Inventor: Eric Connor , Kalpesh Biyani , Scott Hecker , Inez Lees , Paul Mansky , YongQi Mu , Faleh Salaymeh , Hongmin Zhang , David E. Bergbreiter , Grace Huynh , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
IPC: A61K31/785 , C08G73/02 , A61K45/06
CPC classification number: A61K31/785 , A61K45/06 , C08G73/02 , C08G73/0206 , A61K2300/00
Abstract: The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
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公开(公告)号:US09464040B2
公开(公告)日:2016-10-11
申请号:US14742381
申请日:2015-06-17
Applicant: Relypsa, Inc.
Inventor: YongQi Mu
IPC: C07C253/30 , C07C51/62 , C07C67/22 , C07C51/363 , C07C67/307 , C07C253/32
CPC classification number: C07C51/36 , C07C51/363 , C07C51/50 , C07C51/62 , C07C51/64 , C07C67/03 , C07C67/22 , C07C67/307 , C07C67/62 , C07C253/30 , C07C253/32 , C07C69/63 , C07C53/21 , C07C53/50 , C07C255/03
Abstract: The present invention generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent.
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