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公开(公告)号：US20200024309A1
公开(公告)日：2020-01-23
申请号：US16539947
申请日：2019-08-13
发明人： Peter Andrew SMITH , Tucker Curran ROBERTS , Robert I. HIGUCHI , Prasuna PARASELLI , Michael F. T. KOEHLER , Jacob Bradley SCHWARZ , James John CRAWFORD , Cuong Q. LY , Emily J. HANAN , Huiyong HU , Yongsheng CHEN , Zhiyong YU , Paul Colin Michael WINSHIP , Calum McCleod , Toby Blench
IPC分类号： C07K5/11 , A61P31/04 , A61K9/00 , A61K45/06 , A61K38/07 , C07K5/107 , C07K5/083 , C07K7/06 , A61K38/08 , C07K5/097 , A61K38/06
摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
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公开(公告)号：US20210198316A9
公开(公告)日：2021-07-01
申请号：US16539947
申请日：2019-08-13
发明人： Peter Andrew SMITH , Tucker Curran ROBERTS , Robert I. HIGUCHI , Prasuna PARASELLI , Michael F. T. KOEHLER , Jacob Bradley SCHWARZ , James John CRAWFORD , Cuong Q. LY , Emily J. HANAN , Huiyong HU , Yongsheng CHEN , Zhiyong YU , Paul Colin Michael WINSHIP , Calum McCleod , Toby Blench
IPC分类号： C07K5/11 , A61P31/04 , A61K9/00 , A61K45/06 , A61K38/07 , C07K5/107 , C07K5/083 , C07K7/06 , A61K38/08 , C07K5/097 , A61K38/06
摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
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公开(公告)号：US20200239519A1
公开(公告)日：2020-07-30
申请号：US15777509
申请日：2016-11-21
发明人： Yongsheng CHEN , Peter Andrew SMITH , Tucker Curran ROBERTS , Robert I. HIGUCHI , Prasuna PARASELLI , Michael F. T. KOEHLER , Jacob Bradley SCHWARZ , James John CRAWFORD , Cuong Q. LY , Huiyong HU , Zhiyong YU
摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
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公开(公告)号：US20180327367A1
公开(公告)日：2018-11-15
申请号：US15777499
申请日：2016-11-21
发明人： Yongsheng CHEN , Peter Andrew SMITH , Tucker Curran ROBERTS , Robert I. HIGUCHI , Prasuna PARASELLI , Michael F. T. KOEHLER , Jacob Bradley SCHWARZ , James John CRAWFORD , Cuong Q. LY , Emily J. HANAN , Huiyong HU , Zhiyong YU
IPC分类号： C07D245/04 , C07K5/02 , A61K38/08 , A61K38/06 , A61K31/496 , A61K31/546 , A61K38/07 , C07K5/087 , C07K5/103 , C07K5/11 , C07K5/113 , C07K5/117 , C07K7/06 , C07K7/08 , C07K9/00 , A61P31/04 , A61K9/00
CPC分类号： C07D245/04 , A61K9/0014 , A61K31/395 , A61K31/407 , A61K31/4196 , A61K31/43 , A61K31/431 , A61K31/496 , A61K31/545 , A61K31/546 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , A61K2300/00 , A61P31/04 , C07K5/0202 , C07K5/0812 , C07K5/0815 , C07K5/1008 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K5/1024 , C07K7/06 , C07K7/08 , C07K9/008 , Y02A50/404 , Y02A50/406
摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
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公开(公告)号：US20170088582A1
公开(公告)日：2017-03-30
申请号：US15312614
申请日：2015-05-19
发明人： Tucker Curran ROBERTS , Peter Andrew SMITH , Robert I. HIGUCHI , Prasuna PARASELLI , Philippe BERGERON , Michael F.T. KOEHLER , Huiyong HU , Jacob Bradley SCHWARZ , Cuong LY , James CRAWFORD
CPC分类号： C07K5/101 , A61K31/395 , A61K31/407 , A61K31/4196 , A61K31/43 , A61K31/431 , A61K31/496 , A61K31/545 , A61K31/546 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/12 , A61K45/06 , C07K5/0202 , C07K5/0808 , C07K5/0812 , C07K5/0815 , C07K5/1008 , C07K5/1013 , C07K5/1019 , C07K7/06 , C07K7/08 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/483 , A61K2300/00 , A61L2300/00
摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
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公开(公告)号：US20170275334A1
公开(公告)日：2017-09-28
申请号：US15618337
申请日：2017-06-09
发明人： Robert I. HIGUCHI , Tucker Curran ROBERTS , Peter Andrew SMITH , David CAMPBELL , Prasuna PARASELLI
IPC分类号： C07K7/06 , A61K38/07 , A61K45/06 , C07K5/11 , A61K38/06 , A61K38/08 , C07K5/08 , C07K5/113 , C07K5/103 , C07K5/117
CPC分类号： C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , C07K5/08 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K5/1024 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/483
摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
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公开(公告)号：US20140142029A1
公开(公告)日：2014-05-22
申请号：US14086908
申请日：2013-11-21
发明人： Tucker Curran ROBERTS , Peter Andrew SMITH , Robert I. HIGUCHI , David CAMPBELL , Prasuna PARASELLI
CPC分类号： C07K7/06 , A61K38/07 , A61K38/55 , C07K5/0202 , C07K5/081 , C07K5/0812 , C07K5/1019 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
摘要翻译： 本文提供的是抗菌化合物，其中在一些实施方案中的化合物具有广谱生物活性。 在各种实施方案中，化合物通过抑制细菌中必需蛋白质的细菌1型信号肽酶（SpsB）起作用。 还提供了使用本文所述的化合物进行治疗的药物组合物和方法。
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公开(公告)号：US20170073370A1
公开(公告)日：2017-03-16
申请号：US15358100
申请日：2016-11-21
发明人： Tucker Curran ROBERTS , Peter Andrew SMITH , David CAMPBELL , Sergio G. DURON , Robert I. HIGUCHI
CPC分类号： C07K7/06 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K9/10 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K38/00 , A61K38/08 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/38 , Y02A50/47
摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broader spectrum of antibiotic bioactivity compared to the natural product. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
摘要翻译： 本文提供的是抗菌化合物，其中在一些实施方案中的化合物具有广谱生物活性。 本文提供的化合物可以在其它实施方案中克服在细菌信号肽酶（SPase）的限定位置由单个氨基酸突变赋予的抗性，并且在其它实施方案中，与天然产物相比，提供更广谱的抗生素生物活性。 还提供了使用本文所述的化合物进行治疗的药物组合物和方法。
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公开(公告)号：US20160194358A1
公开(公告)日：2016-07-07
申请号：US14911823
申请日：2014-08-14
发明人： Peter Andrew SMITH , Tucker Curran ROBERTS , Robert I. HIGUCHI , Prasuna PARASELLI , Michael F.T. KOEHLER , James John CRAWFORD
IPC分类号： C07K7/06
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , Y02A50/401 , Y02A50/406 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/483
摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
摘要翻译： 本文提供的是抗菌化合物，其中在一些实施方案中的化合物具有广谱生物活性。 本文提供的化合物在其它实施方案中可以克服在细菌信号肽酶（SPases）的限定位置由单个氨基酸突变所赋予的抗性，并且在其它实施方案中提供广谱抗生素生物活性。 还提供了使用本文所述的化合物进行治疗的药物组合物和方法。
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公开(公告)号：US20150166605A1
公开(公告)日：2015-06-18
申请号：US14631762
申请日：2015-02-25
发明人： Robert I. HIGUCHI , Tucker Curran ROBERTS , Peter Andrew SMITH , David CAMPBELL , Prasuna PARASELLI
CPC分类号： C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , C07K5/08 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K5/1024 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
摘要翻译： 本文提供的是抗菌化合物，其中在一些实施方案中的化合物具有广谱生物活性。 本文提供的化合物在其它实施方案中可以克服在细菌信号肽酶（SPases）的限定位置由单个氨基酸突变所赋予的抗性，并且在其它实施方案中提供广谱抗生素生物活性。 还提供了使用本文所述的化合物进行治疗的药物组合物和方法。
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